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- W2129127655 abstract "Abstract The avian erythroblastosis virus (AEV) and the avian myelocytomatosis virus 29 (MCV) induce the rapid appearance of tumors in birds. Although basically similar in nucleotide sequence, the genomes of MCV and AEV each contain a unique putative oncogene ( onc MCV and onc AEV ); each virus transforms at least two cell types in vivo and in vitro, suggesting that multiple functional domains may exist within onc AEV and onc MCV . Virus-coded polyproteins were previously detected in cells infected by MCV and AEV by the use of antibodies directed against virion proteins of the closely related avian sarcoma virus. However, AEV and MCV may encode as yet undetected proteins that do not react with antibodies directed against avian sarcoma virus proteins. mRNA was examined from MCV- and AEV-infected cells as a means of determining whether such additional proteins might exist. Our results indicate that MCV-infected cells contain only one RNA with sequences corresponding to onc MCV ; this 5.4 kb RNA corresponds in size to the MCV genome and probably encodes P110, the previously identified MCV polyprotein. The absence of any other MCV-specific mRNAs suggests that P110 (or presently unidentified derivatives) may be solely responsible for transformation by MCV. In contrast to our results with MCV, we found that AEV-infected fibroblasts and erythroblasts contain two species of RNA that anneal with cDNA corresponding to the majority of onc AEV . For several strains of AEV, the two intracellular viral RNAs have sizes of 5.3 and 3.5 kb, but in one instance have sizes 6.1 and 4.3 kb. We analyzed the distribution of onc AEV -specific sequences within the two AEV RNAs by hybridization with cDNAs corresponding to different sections of onc AEV . As expected, cDNAs from all regions of onc AEV anneal with the larger AEV RNA; this RNA probably encodes the AEV polyprotein. By contrast, hybridization results for the subgenomic RNA indicate that it contains the 3′ half of onc AEV and a leader sequence splied from the 5′ end of the viral genome. Our analyses of mRNA expression for two multipotential oncogenic retroviruses thus yield contrasting results. The existence of two intracellular AEV RNAs suggests that onc AEV may encode two distinct proteins. MCV, however, apparently encodes only a single viral protein. A third defective leukemia virus, the avian myeloblastosis virus (AMV), generates a subgenomic 2.3 kb mRNA. We conclude that each of these three defective avian retroviruses employs a distint scheme for expression of its oncogenicity." @default.
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- W2129127655 title "Virus-specific RNAs in cells infected by avian myelocytomatosis virus and avian erythroblastosis virus: Modes of oncogene expression" @default.
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- W2129127655 doi "https://doi.org/10.1016/0092-8674(81)90293-2" @default.
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