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• W2129129792 abstract "Incidental findings (IF) are a well-recognized problem in radiological screening programmes. 1 Edwards J.T. Wood C.J. Mendelson R.M. et al. Extracolonic findings at virtual colonoscopy: implications for screening programs. Am J Gastroenterol. 2001; 96: 3009-3012 Crossref PubMed Google Scholar , 2 Mirza S. Malik T.H. Ahmed A. et al. Incidental findings on magnetic resonance imaging screening for cerebellopontine angle tumours. J Laryngol Otol. 2000; 114: 750-754 PubMed Google Scholar , 3 Vierikko T. Jarvenpaa R. Autti T. et al. Chest CT screening of asbestos-exposed workers: lung lesions and incidental findings. Eur Respir J. 2007; 29: 78-84 Crossref PubMed Scopus (70) Google Scholar An unexpected radiological abnormality outside the screening programme's anatomical area of interest can occasionally lead to serendipitous early diagnosis of significant disease. It can also lead to a series of arguably unnecessary further investigations, anxiety, and morbidity. However, with any screening programme the role of the responsible clinician is clear and there is usually no doubt who will take responsibility for managing the consequences of any IF. The same can not be said for radiological IF that occur within research studies. There is a rapidly expanding body of literature that has now examined the problem of IF in volunteers who enrol in brain imaging studies. 4 Illes J. “Pandora's box” of incidental findings in brain imaging research. Nat Clin Pract Neurol. 2006; 2: 60-61 Crossref PubMed Scopus (27) Google Scholar , 5 Illes J. Kirschen M.P. Edwards E. et al. Ethics. Incidental findings in brain imaging research. Science. 2006; 311: 783-784 Crossref PubMed Scopus (208) Google Scholar , 6 Brown D.A. Hasso A.N. Toward a uniform policy for handling incidental findings in neuroimaging research. AJNR Am J Neuroradiol. 2008; 29: 1425-1427 Crossref PubMed Scopus (18) Google Scholar The problem has surfaced in North American brain imaging research centres for a number of reasons. More than in any other field large numbers of asymptomatic normal volunteers are recruited for brain magnetic resonance imaging (MRI) studies and, in particular, for functional MRI (fMRI). It is a recognized problem that these studies may be supervised by non-medically trained researchers, such as neuroscientists and psychologists, and the question of how the substantial numbers of IF should be best managed needs attention. 7 Miller F.G. Mello M.M. Joffe S. Incidental findings in human subjects research: what do investigators owe research participants?. J Law Med Ethics. 2008; 36 (211): 271-279 Crossref PubMed Scopus (85) Google Scholar , 8 Kim B.S. Illes J. Kaplan R.T. et al. Incidental findings on pediatric MR images of the brain. AJNR Am J Neuroradiol. 2002; 23: 1674-1677 PubMed Google Scholar" @default.
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• W2129129792 title "Incidental findings in “normal” volunteers" @default.
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