Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129131406> ?p ?o ?g. }
- W2129131406 endingPage "694" @default.
- W2129131406 startingPage "686" @default.
- W2129131406 abstract "Despite significant advances in cancer therapy, cancer-related mobility and mortality are still rising. Alternative strategies such as cancer prevention thus become essential. Probiotics represent an emerging option for cancer prevention, but studies are limited to colon cancers. The efficiency of probiotics in the prevention of other cancers and the correlative mechanism remains to be explored. A novel probiotics Lactobacillus salivarius REN (L. salivarius REN) was isolated from centenarians at Bama of China, which showed highly potent antigenotoxicity in an initial assay. 4-nitroquioline 1-oxide (4NQO)-induced oral cancer model was introduced to study the anticancer activity of L. salivarius REN in vivo. The results indicated that oral administration of probiotic L. salivarius REN or its secretions could effectively suppress 4NQO-induced oral carcinogenesis in the initial and postinitial stage, and the inhibition was in a dose-dependent manner. A significant decrease of neoplasm incidence (65%-0%) was detected in rats fed with the high dose of L. salivarius REN [5 × 10(10) CFU/kg body weight (bw)/d]. In vivo evidences indicated that the probiotics inhibited 4NQO-induced oral cancer by protecting DNA against oxidative damage and downregulating COX-2 expression. L. salivarius REN treatment significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and induced apoptosis in a dose-dependent manner. Our findings suggest that probiotics may act as potential agents for oral cancer prevention. This is the first report showing the inhibitory effect of the probiotics on oral carcinogenesis." @default.
- W2129131406 created "2016-06-24" @default.
- W2129131406 creator A5002661071 @default.
- W2129131406 creator A5015798048 @default.
- W2129131406 creator A5017115807 @default.
- W2129131406 creator A5019397668 @default.
- W2129131406 creator A5023986637 @default.
- W2129131406 creator A5024467385 @default.
- W2129131406 creator A5029360582 @default.
- W2129131406 creator A5033105884 @default.
- W2129131406 creator A5045889044 @default.
- W2129131406 creator A5053863947 @default.
- W2129131406 creator A5076184286 @default.
- W2129131406 creator A5080733133 @default.
- W2129131406 date "2013-07-01" @default.
- W2129131406 modified "2023-10-16" @default.
- W2129131406 title "<i>Lactobacillus Salivarius</i> REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide" @default.
- W2129131406 cites W136833318 @default.
- W2129131406 cites W1544146655 @default.
- W2129131406 cites W1940221461 @default.
- W2129131406 cites W1964755431 @default.
- W2129131406 cites W1967156631 @default.
- W2129131406 cites W1971147829 @default.
- W2129131406 cites W1987578146 @default.
- W2129131406 cites W1987685119 @default.
- W2129131406 cites W1999416710 @default.
- W2129131406 cites W1999444394 @default.
- W2129131406 cites W2003708547 @default.
- W2129131406 cites W2009170813 @default.
- W2129131406 cites W2030808013 @default.
- W2129131406 cites W2032230795 @default.
- W2129131406 cites W2036333716 @default.
- W2129131406 cites W2038309995 @default.
- W2129131406 cites W2045805424 @default.
- W2129131406 cites W2051148867 @default.
- W2129131406 cites W2064546820 @default.
- W2129131406 cites W2068245831 @default.
- W2129131406 cites W2073332363 @default.
- W2129131406 cites W2080513230 @default.
- W2129131406 cites W2082707689 @default.
- W2129131406 cites W2088179332 @default.
- W2129131406 cites W2089246633 @default.
- W2129131406 cites W2090703365 @default.
- W2129131406 cites W2111337712 @default.
- W2129131406 cites W2112846730 @default.
- W2129131406 cites W2114374331 @default.
- W2129131406 cites W2125664451 @default.
- W2129131406 cites W2127161627 @default.
- W2129131406 cites W2135767556 @default.
- W2129131406 cites W2151534353 @default.
- W2129131406 cites W2158131645 @default.
- W2129131406 cites W2158968701 @default.
- W2129131406 cites W2172010641 @default.
- W2129131406 cites W2324693021 @default.
- W2129131406 cites W4238350906 @default.
- W2129131406 doi "https://doi.org/10.1158/1940-6207.capr-12-0427" @default.
- W2129131406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23658366" @default.
- W2129131406 hasPublicationYear "2013" @default.
- W2129131406 type Work @default.
- W2129131406 sameAs 2129131406 @default.
- W2129131406 citedByCount "63" @default.
- W2129131406 countsByYear W21291314062014 @default.
- W2129131406 countsByYear W21291314062015 @default.
- W2129131406 countsByYear W21291314062016 @default.
- W2129131406 countsByYear W21291314062017 @default.
- W2129131406 countsByYear W21291314062018 @default.
- W2129131406 countsByYear W21291314062019 @default.
- W2129131406 countsByYear W21291314062020 @default.
- W2129131406 countsByYear W21291314062021 @default.
- W2129131406 countsByYear W21291314062022 @default.
- W2129131406 countsByYear W21291314062023 @default.
- W2129131406 crossrefType "journal-article" @default.
- W2129131406 hasAuthorship W2129131406A5002661071 @default.
- W2129131406 hasAuthorship W2129131406A5015798048 @default.
- W2129131406 hasAuthorship W2129131406A5017115807 @default.
- W2129131406 hasAuthorship W2129131406A5019397668 @default.
- W2129131406 hasAuthorship W2129131406A5023986637 @default.
- W2129131406 hasAuthorship W2129131406A5024467385 @default.
- W2129131406 hasAuthorship W2129131406A5029360582 @default.
- W2129131406 hasAuthorship W2129131406A5033105884 @default.
- W2129131406 hasAuthorship W2129131406A5045889044 @default.
- W2129131406 hasAuthorship W2129131406A5053863947 @default.
- W2129131406 hasAuthorship W2129131406A5076184286 @default.
- W2129131406 hasAuthorship W2129131406A5080733133 @default.
- W2129131406 hasBestOaLocation W21291314061 @default.
- W2129131406 hasConcept C121608353 @default.
- W2129131406 hasConcept C126322002 @default.
- W2129131406 hasConcept C150903083 @default.
- W2129131406 hasConcept C190283241 @default.
- W2129131406 hasConcept C203014093 @default.
- W2129131406 hasConcept C204232928 @default.
- W2129131406 hasConcept C207001950 @default.
- W2129131406 hasConcept C2777056448 @default.
- W2129131406 hasConcept C2780234812 @default.
- W2129131406 hasConcept C2780255968 @default.
- W2129131406 hasConcept C2780795924 @default.
- W2129131406 hasConcept C34688535 @default.
- W2129131406 hasConcept C502942594 @default.