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- W2129136208 abstract "ABSTRACT During latency of herpes simplex virus type 1 in the neurons of the peripheral nervous system, the major transcript detected is the 2-kb latency-associated transcript (LAT) intron. During lytic infection, this intron has been shown to associate with ribosomes, suggesting a role in modifying the translational machinery of infected cells. In this study we show, using LAT-transfected cells, that the interaction of the intron with the 60S ribosomal subunit leads to irreversible changes in the sedimentation profile of this subunit in the nucleus. Furthermore, the 2-kb LAT intron is transported to the cytoplasm as part of the 60S ribosomal subunit, using a CRM1-dependent pathway." @default.
- W2129136208 created "2016-06-24" @default.
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- W2129136208 date "2007-07-15" @default.
- W2129136208 modified "2023-09-26" @default.
- W2129136208 title "The Stable 2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1 Can Alter the Assembly of the 60S Ribosomal Subunit and Is Exported from Nucleus to Cytoplasm by a CRM1-Dependent Pathway" @default.
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- W2129136208 doi "https://doi.org/10.1128/jvi.00282-07" @default.
- W2129136208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1933333" @default.
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