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• W2129138941 abstract "Vaccines for rapidly evolving pathogens will confer lasting immunity if they elicit antibodies recognizing conserved epitopes, such as a receptor-binding site (RBS). From characteristics of an influenza-virus RBS-directed antibody, we devised a signature motif to search for similar antibodies. We identified, from three vaccinees, over 100 candidates encoded by 11 different VH genes. Crystal structures show that antibodies in this class engage the hemagglutinin RBS and mimic binding of the receptor, sialic acid, by supplying a critical dipeptide on their projecting, heavy-chain third complementarity determining region. They share contacts with conserved, receptor-binding residues but contact different residues on the RBS periphery, limiting the likelihood of viral escape when several such antibodies are present. These data show that related modes of RBS recognition can arise from different germline origins and mature through diverse affinity maturation pathways. Immunogens focused on an RBS-directed response will thus have a broad range of B cell targets." @default.
• W2129138941 created "2016-06-24" @default.
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• W2129138941 date "2015-05-01" @default.
• W2129138941 modified "2023-10-15" @default.
• W2129138941 title "Viral Receptor-Binding Site Antibodies with Diverse Germline Origins" @default.
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• W2129138941 doi "https://doi.org/10.1016/j.cell.2015.04.028" @default.
• W2129138941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4441819" @default.
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• W2129138941 hasPublicationYear "2015" @default.
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