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• W2129144944 startingPage "515" @default.
• W2129144944 abstract "Abstract Background: Central venous catheter (CVC)-related bloodstream infections (BSIs) are known to increase rates of morbidity and mortality in both inpatients and outpatients, including hematology-oncology patients and those undergoing hemodialysis or home infusion therapy. Biofilm-associated organisms on the lumens of these catheters have reduced susceptibility to antimicrobial chemotherapy. This study tested the efficacy of tetrasodium EDTA as a catheter lock solution on biofilms of several clinically relevant microorganisms. Methods: Biofilms of Staphylococcus epidermidis , methicillin-resistant S. aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae , and Candida albicans were grown to levels of approximately 1 × 10 5 colony-forming units (CFU)/cm −1 on CVC segments in a model system, then subjected to the tetrasodium EDTA lock treatment. Results: Comparisons of biofilms before and after exposure to the 40-mg/mL −1 tetrasodium EDTA lock for 21 hours showed that the biofilm viable cell counts of all organisms tested were significantly reduced ( P < .05) after exposure to the treatment. Conclusion: Antimicrobial lock treatment using 40 mg/mL −1 of tetrasodium EDTA for at least 21 hours could significantly reduce or potentially eradicate CVC-associated bio-films of clinically relevant microorganisms ( Infect Control Hosp Epidemiol 2005;26:515-519)." @default.
• W2129144944 created "2016-06-24" @default.
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• W2129144944 date "2005-06-01" @default.
• W2129144944 modified "2023-10-17" @default.
• W2129144944 title "Tetrasodium EDTA as a Novel Central Venous Catheter Lock Solution Against Biofilm" @default.
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• W2129144944 doi "https://doi.org/10.1086/502577" @default.
• W2129144944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16018425" @default.
• W2129144944 hasPublicationYear "2005" @default.
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