FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129151898> ?p ?o ?g. }

• W2129151898 endingPage "1426" @default.
• W2129151898 startingPage "1417" @default.
• W2129151898 abstract "Dental follicle cells (DFCs) are believed contain the precursor cells of the periodontium and can form cell sheets by secreting extracellular matrix (ECM) proteins. Cell sheet engineering has been recently developed and applied successfully in the field of tissue regeneration. However, research on the in vitro characteristics of DFC sheets is lacking and an assessment of whether DFC sheets can produce periodontal tissues in vivo has not been reported. To test the characteristics and applicability of DFC sheets in this field, we established a co-culture system of rat DFCs and Hertwig's epithelial root sheath (HERS) cells in vitro, and included the following controls: a co-culture of DFCs and alveolar mucosa epithelial cells, DFCs with no cells in the upper chamber, and DFCs cultured without an upper chamber. After 3 weeks of co-culturing the cells, the DFC sheets were transplanted into adult male rats' omenta. One week after co-culturing DFCs with HERS cells, mRNA levels of collagen type I (COL-1), alkaline phosphatase (ALP), runt related transcription factor 2 (Runx 2) and bone sialoprotein (BSP) were increased significantly. In addition, after 3 weeks of co-culturing the cells, the numbers of ALP-, osteocalcin (OCN)-, BSP- and osteoprotegerin (OPG)-positive DFCs increased. The DFCs also produced more calcified nodules and exhibited an increased number of subcellular organelles, which are important for protein synthesis and secretion. Moreover, gap junctions were found between the experimental DFCs within the sheet. Five weeks of in vivo growth of DFC sheets pre-exposed to HERS cells led to the formation of cementum-like tissues, which were positive for OCN, BSP and OPG, as well as the formation of periodontal ligament-like tissues, which were positive for COL-1. In contrast, control cells only produced fibrous tissues. These results indicate that the DFC sheets induced by HERS cells are able to produce periodontal tissues through epithelial-mesenchymal interactions. Therefore, DFC sheets may be useful in the field of periodontium regeneration." @default.
• W2129151898 created "2016-06-24" @default.
• W2129151898 creator A5006239432 @default.
• W2129151898 creator A5013938816 @default.
• W2129151898 creator A5022161546 @default.
• W2129151898 creator A5022658461 @default.
• W2129151898 creator A5030702262 @default.
• W2129151898 creator A5035358476 @default.
• W2129151898 creator A5051812806 @default.
• W2129151898 creator A5058060903 @default.
• W2129151898 creator A5064069257 @default.
• W2129151898 creator A5066816626 @default.
• W2129151898 date "2011-06-01" @default.
• W2129151898 modified "2023-09-25" @default.
• W2129151898 title "Cementum- and periodontal ligament-like tissue formation by dental follicle cell sheets co-cultured with Hertwig's epithelial root sheath cells" @default.
• W2129151898 cites W1964834421 @default.
• W2129151898 cites W1979023229 @default.
• W2129151898 cites W1981420119 @default.
• W2129151898 cites W1983091320 @default.
• W2129151898 cites W1987594610 @default.
• W2129151898 cites W1993475011 @default.
• W2129151898 cites W2002106980 @default.
• W2129151898 cites W2010361875 @default.
• W2129151898 cites W2015191928 @default.
• W2129151898 cites W2015986989 @default.
• W2129151898 cites W2024579131 @default.
• W2129151898 cites W2027021610 @default.
• W2129151898 cites W2029629119 @default.
• W2129151898 cites W2034435462 @default.
• W2129151898 cites W2038579798 @default.
• W2129151898 cites W2039322645 @default.
• W2129151898 cites W2039606117 @default.
• W2129151898 cites W2041267963 @default.
• W2129151898 cites W2042391882 @default.
• W2129151898 cites W2046910768 @default.
• W2129151898 cites W2072054624 @default.
• W2129151898 cites W2074780271 @default.
• W2129151898 cites W2076529839 @default.
• W2129151898 cites W2080433548 @default.
• W2129151898 cites W2081128798 @default.
• W2129151898 cites W2081317694 @default.
• W2129151898 cites W2086731325 @default.
• W2129151898 cites W2096133639 @default.
• W2129151898 cites W2099813054 @default.
• W2129151898 cites W2101549626 @default.
• W2129151898 cites W2104370230 @default.
• W2129151898 cites W2112626453 @default.
• W2129151898 cites W2113969342 @default.
• W2129151898 cites W2130324121 @default.
• W2129151898 cites W2147611167 @default.
• W2129151898 cites W2149997157 @default.
• W2129151898 cites W2151751964 @default.
• W2129151898 cites W2152657611 @default.
• W2129151898 doi "https://doi.org/10.1016/j.bone.2011.02.016" @default.
• W2129151898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21376148" @default.
• W2129151898 hasPublicationYear "2011" @default.
• W2129151898 type Work @default.
• W2129151898 sameAs 2129151898 @default.
• W2129151898 citedByCount "55" @default.
• W2129151898 countsByYear W21291518982012 @default.
• W2129151898 countsByYear W21291518982013 @default.
• W2129151898 countsByYear W21291518982014 @default.
• W2129151898 countsByYear W21291518982015 @default.
• W2129151898 countsByYear W21291518982016 @default.
• W2129151898 countsByYear W21291518982017 @default.
• W2129151898 countsByYear W21291518982018 @default.
• W2129151898 countsByYear W21291518982019 @default.
• W2129151898 countsByYear W21291518982020 @default.
• W2129151898 countsByYear W21291518982021 @default.
• W2129151898 countsByYear W21291518982022 @default.
• W2129151898 countsByYear W21291518982023 @default.
• W2129151898 crossrefType "journal-article" @default.
• W2129151898 hasAuthorship W2129151898A5006239432 @default.
• W2129151898 hasAuthorship W2129151898A5013938816 @default.
• W2129151898 hasAuthorship W2129151898A5022161546 @default.
• W2129151898 hasAuthorship W2129151898A5022658461 @default.
• W2129151898 hasAuthorship W2129151898A5030702262 @default.
• W2129151898 hasAuthorship W2129151898A5035358476 @default.
• W2129151898 hasAuthorship W2129151898A5051812806 @default.
• W2129151898 hasAuthorship W2129151898A5058060903 @default.
• W2129151898 hasAuthorship W2129151898A5064069257 @default.
• W2129151898 hasAuthorship W2129151898A5066816626 @default.
• W2129151898 hasConcept C131075544 @default.
• W2129151898 hasConcept C142724271 @default.
• W2129151898 hasConcept C151279780 @default.
• W2129151898 hasConcept C160160445 @default.
• W2129151898 hasConcept C181199279 @default.
• W2129151898 hasConcept C185592680 @default.
• W2129151898 hasConcept C198826908 @default.
• W2129151898 hasConcept C199343813 @default.
• W2129151898 hasConcept C2776211174 @default.
• W2129151898 hasConcept C2776432469 @default.
• W2129151898 hasConcept C2777894202 @default.
• W2129151898 hasConcept C2779263046 @default.
• W2129151898 hasConcept C2779886569 @default.
• W2129151898 hasConcept C2908931166 @default.
• W2129151898 hasConcept C41868710 @default.
• W2129151898 hasConcept C55493867 @default.

• next