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- W2129157343 abstract "Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of approximately 40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with beta-strands that form a jelly-roll beta-sandwich. The receptors recognize soluble or cell-surface-bound ligands and mediate diverse cellular responses. Activation of intracellular signals is mediated at least in part by the association of proteins with a RING finger motif or a death domain to the cytoplasmic domains of the receptors. In addition to cell-membrane-bound receptors soluble forms have been described for most of the receptors. Activation of intracellular signals not only occurs through ligand binding to the receptors but cross-linking of at least some members of the ligand family can regulate cell functions." @default.
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- W2129157343 date "1996-07-01" @default.
- W2129157343 modified "2023-10-06" @default.
- W2129157343 title "The nerve growth factor/tumor necrosis factor receptor family" @default.
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- W2129157343 doi "https://doi.org/10.1002/jlb.60.1.1" @default.
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