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• W2129172618 endingPage "2064" @default.
• W2129172618 startingPage "2050" @default.
• W2129172618 abstract "Traditionally, T cells were CD4+ helper or CD8+ cytotoxic T cells, and with antibodies, they were the soldiers of immunity. Now, many functionally distinct subsets of activated CD4+ and CD8+ T cells have been described, each with distinct cytokine and transcription factor expression. For CD4+ T cells, these include Th1 cells expressing the transcription factor T-bet and cytokines IL-2, IFN-γ, and TNF-β; Th2 cells expressing GATA-3 and the cytokines IL-4, IL-5, and IL-13; and Th17 cells expressing RORγt and cytokines IL-17A, IL-17F, IL-21, and IL-22. The cytokines produced determine the immune inflammation that they mediate. T cells of the effector lineage can be naïve T cells, recently activated T cells, or memory T cells that can be distinguished by cell surface markers. T regulatory cells or spies were characterized as CD8+ T cells expressing I-J in the 1970s. In the 1980s, suppressor cells fell into disrepute when the gene for I-J was not present in the mouse MHC I region. At that time, a CD4+ T cell expressing CD25, the IL-2 receptor-α, was identified to transfer transplant tolerance. This was the same phenotype of activated CD4+ CD25+ T cells that mediated rejection. Thus, the cells that could induce tolerance and undermine rejection had similar badges and uniforms as the cells effecting rejection. Later, FOXP3, a transcription factor that confers suppressor function, was described and distinguishes T regulatory cells from effector T cells. Many subtypes of T regulatory cells can be characterized by different expressions of cytokines and receptors for cytokines or chemokines. In intense immune inflammation, T regulatory cells express cytokines characteristic of effector cells; for example, Th1-like T regulatory cells express T-bet, and IFN-γ-like Th1 cells and effector T cells can change sides by converting to T regulatory cells. Effector T cells and T regulatory cells use similar molecules to be activated and mediate their function, and thus, it can be very difficult to distinguish soldiers from spies." @default.
• W2129172618 created "2016-06-24" @default.
• W2129172618 creator A5020556945 @default.
• W2129172618 date "2015-11-01" @default.
• W2129172618 modified "2023-10-13" @default.
• W2129172618 title "T Cells" @default.
• W2129172618 cites W118805750 @default.
• W2129172618 cites W1486722793 @default.
• W2129172618 cites W1499151513 @default.
• W2129172618 cites W1534237017 @default.
• W2129172618 cites W1567420244 @default.
• W2129172618 cites W1575812743 @default.
• W2129172618 cites W1582941402 @default.
• W2129172618 cites W1599880469 @default.
• W2129172618 cites W1634158134 @default.
• W2129172618 cites W1661441964 @default.
• W2129172618 cites W1838830866 @default.
• W2129172618 cites W1891651069 @default.
• W2129172618 cites W1893446316 @default.
• W2129172618 cites W1964010927 @default.
• W2129172618 cites W1966073503 @default.
• W2129172618 cites W1966755152 @default.
• W2129172618 cites W1966922635 @default.
• W2129172618 cites W1967520584 @default.
• W2129172618 cites W1972922050 @default.
• W2129172618 cites W1975672348 @default.
• W2129172618 cites W1976696463 @default.
• W2129172618 cites W1977165060 @default.
• W2129172618 cites W1977913178 @default.
• W2129172618 cites W1980404080 @default.
• W2129172618 cites W1982180094 @default.
• W2129172618 cites W1987076250 @default.
• W2129172618 cites W1987802826 @default.
• W2129172618 cites W1988368135 @default.
• W2129172618 cites W1991232823 @default.
• W2129172618 cites W1994668373 @default.
• W2129172618 cites W1996532235 @default.
• W2129172618 cites W1996746749 @default.
• W2129172618 cites W1997534025 @default.
• W2129172618 cites W1999200556 @default.
• W2129172618 cites W2000301091 @default.
• W2129172618 cites W2001051250 @default.
• W2129172618 cites W2001360021 @default.
• W2129172618 cites W2002726823 @default.
• W2129172618 cites W2003969862 @default.
• W2129172618 cites W2004282938 @default.
• W2129172618 cites W2004660702 @default.
• W2129172618 cites W2005721095 @default.
• W2129172618 cites W2005855139 @default.
• W2129172618 cites W2006741811 @default.
• W2129172618 cites W2006756007 @default.
• W2129172618 cites W2007894666 @default.
• W2129172618 cites W2008406050 @default.
• W2129172618 cites W2008686731 @default.
• W2129172618 cites W2008713912 @default.
• W2129172618 cites W2009194913 @default.
• W2129172618 cites W2009390908 @default.
• W2129172618 cites W2009794923 @default.
• W2129172618 cites W2012014689 @default.
• W2129172618 cites W2013436886 @default.
• W2129172618 cites W2015179134 @default.
• W2129172618 cites W2018506059 @default.
• W2129172618 cites W2021788662 @default.
• W2129172618 cites W2022642477 @default.
• W2129172618 cites W2024441858 @default.
• W2129172618 cites W2024490058 @default.
• W2129172618 cites W2025492877 @default.
• W2129172618 cites W2026458427 @default.
• W2129172618 cites W2027581425 @default.
• W2129172618 cites W2029993034 @default.
• W2129172618 cites W2030284768 @default.
• W2129172618 cites W2031011895 @default.
• W2129172618 cites W2033377415 @default.
• W2129172618 cites W2034430001 @default.
• W2129172618 cites W2035377036 @default.
• W2129172618 cites W2039103537 @default.
• W2129172618 cites W2040572245 @default.
• W2129172618 cites W2042336731 @default.
• W2129172618 cites W2044063309 @default.
• W2129172618 cites W2045343528 @default.
• W2129172618 cites W2045346081 @default.
• W2129172618 cites W2046075122 @default.
• W2129172618 cites W2054951100 @default.
• W2129172618 cites W2056236326 @default.
• W2129172618 cites W2056927502 @default.
• W2129172618 cites W2058729893 @default.
• W2129172618 cites W2059283750 @default.
• W2129172618 cites W2060095976 @default.
• W2129172618 cites W2062522397 @default.
• W2129172618 cites W2063579960 @default.
• W2129172618 cites W2066671159 @default.
• W2129172618 cites W2067752500 @default.
• W2129172618 cites W2068238618 @default.
• W2129172618 cites W2068598910 @default.
• W2129172618 cites W2069922064 @default.
• W2129172618 cites W2070247501 @default.
• W2129172618 cites W2070685885 @default.
• W2129172618 cites W2073242835 @default.

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