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• W2129172649 abstract "SUMMARY Diversity in adaptive responses is common within species and populations, especially when the heterogeneity of the frequently large populations found in environments is considered. By focusing on events in a single clonal population undergoing a single transition, we discuss how environmental cues and changes in growth rate initiate a multiplicity of adaptive pathways. Adaptation is a comprehensive process, and stochastic, regulatory, epigenetic, and mutational changes can contribute to fitness and overlap in timing and frequency. We identify culture history as a major determinant of both regulatory adaptations and microevolutionary change. Population history before a transition determines heterogeneities due to errors in translation, stochastic differences in regulation, the presence of aged, damaged, cheating, or dormant cells, and variations in intracellular metabolite or regulator concentrations. It matters whether bacteria come from dense, slow-growing, stressed, or structured states. Genotypic adaptations are history dependent due to variations in mutation supply, contingency gene changes, phase variation, lateral gene transfer, and genome amplifications. Phenotypic adaptations underpin genotypic changes in situations such as stress-induced mutagenesis or prophage induction or in biofilms to give a continuum of adaptive possibilities. Evolutionary selection additionally provides diverse adaptive outcomes in a single transition and generally does not result in single fitter types. The totality of heterogeneities in an adapting population increases the chance that at least some individuals meet immediate or future challenges. However, heterogeneity complicates the adaptomics of single transitions, and we propose that subpopulations will need to be integrated into future population biology and systems biology predictions of bacterial behavior." @default.
• W2129172649 created "2016-06-24" @default.
• W2129172649 creator A5017774001 @default.
• W2129172649 creator A5048243099 @default.
• W2129172649 creator A5057864174 @default.
• W2129172649 date "2012-09-01" @default.
• W2129172649 modified "2023-10-15" @default.
• W2129172649 title "Culture History and Population Heterogeneity as Determinants of Bacterial Adaptation: the Adaptomics of a Single Environmental Transition" @default.
• W2129172649 cites W103093766 @default.
• W2129172649 cites W1485005536 @default.
• W2129172649 cites W1485510133 @default.
• W2129172649 cites W1488210495 @default.
• W2129172649 cites W1511212618 @default.
• W2129172649 cites W1513575096 @default.
• W2129172649 cites W1527303322 @default.
• W2129172649 cites W1544674266 @default.
• W2129172649 cites W1545678009 @default.
• W2129172649 cites W1556215826 @default.
• W2129172649 cites W1583030352 @default.
• W2129172649 cites W1590222219 @default.
• W2129172649 cites W1590850319 @default.
• W2129172649 cites W1604915411 @default.
• W2129172649 cites W16084811 @default.
• W2129172649 cites W1608826984 @default.
• W2129172649 cites W1641873288 @default.
• W2129172649 cites W1643659384 @default.
• W2129172649 cites W1649215506 @default.
• W2129172649 cites W1666867306 @default.
• W2129172649 cites W1673445440 @default.
• W2129172649 cites W1697620700 @default.
• W2129172649 cites W1814402876 @default.
• W2129172649 cites W1823198322 @default.
• W2129172649 cites W1827567297 @default.
• W2129172649 cites W1830688004 @default.
• W2129172649 cites W1849317485 @default.
• W2129172649 cites W1880811828 @default.
• W2129172649 cites W1896232177 @default.
• W2129172649 cites W1896995948 @default.
• W2129172649 cites W1924482204 @default.
• W2129172649 cites W1955582561 @default.
• W2129172649 cites W1962093706 @default.
• W2129172649 cites W1963611280 @default.
• W2129172649 cites W1963695230 @default.
• W2129172649 cites W1965552201 @default.
• W2129172649 cites W1965869751 @default.
• W2129172649 cites W1966532618 @default.
• W2129172649 cites W1966822128 @default.
• W2129172649 cites W1967437164 @default.
• W2129172649 cites W1967848390 @default.
• W2129172649 cites W1968330084 @default.
• W2129172649 cites W1969765938 @default.
• W2129172649 cites W1970561846 @default.
• W2129172649 cites W1970793246 @default.
• W2129172649 cites W1972304020 @default.
• W2129172649 cites W1973231206 @default.
• W2129172649 cites W1973276840 @default.
• W2129172649 cites W1975424511 @default.
• W2129172649 cites W1976841360 @default.
• W2129172649 cites W1977371245 @default.
• W2129172649 cites W1977553831 @default.
• W2129172649 cites W1977592340 @default.
• W2129172649 cites W1977852064 @default.
• W2129172649 cites W1979477952 @default.
• W2129172649 cites W1980462584 @default.
• W2129172649 cites W1980561232 @default.
• W2129172649 cites W1982702194 @default.
• W2129172649 cites W1984571004 @default.
• W2129172649 cites W1984628925 @default.
• W2129172649 cites W1984876660 @default.
• W2129172649 cites W1985002373 @default.
• W2129172649 cites W1985687704 @default.
• W2129172649 cites W1986115705 @default.
• W2129172649 cites W1988035945 @default.
• W2129172649 cites W1988772211 @default.
• W2129172649 cites W1991642577 @default.
• W2129172649 cites W1992572387 @default.
• W2129172649 cites W1992783733 @default.
• W2129172649 cites W1993305583 @default.
• W2129172649 cites W199367124 @default.
• W2129172649 cites W1994811761 @default.
• W2129172649 cites W1995203323 @default.
• W2129172649 cites W1995962422 @default.
• W2129172649 cites W1996064131 @default.
• W2129172649 cites W1996082438 @default.
• W2129172649 cites W1998911481 @default.
• W2129172649 cites W1999920042 @default.
• W2129172649 cites W2000914749 @default.
• W2129172649 cites W2002895409 @default.
• W2129172649 cites W2003399752 @default.
• W2129172649 cites W2004256008 @default.
• W2129172649 cites W2005100412 @default.
• W2129172649 cites W2005327412 @default.
• W2129172649 cites W2005869314 @default.
• W2129172649 cites W2007260352 @default.
• W2129172649 cites W2007886868 @default.
• W2129172649 cites W2012266043 @default.
• W2129172649 cites W2012567238 @default.
• W2129172649 cites W2012766690 @default.

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