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• W2129173665 abstract "Electrophysiological experiments on single myocytes obtained from Purkinje fibres and ventricular tissue of adult rabbit hearts were done to compare the contributions of three potassium (K + ) currents to the action potentials in these two tissues. In Purkinje cells reductions in extracellular potassium, [K + ] o , from normal (5.4 mM) to 2.0 mM resulted in a large hyperpolarization and marked lengthening of the action potential. In ventricular myocytes, these changes were much less pronounced. Voltage clamp measurements demonstrated that these differences were mainly due to a much smaller inward rectifier K + current, I K1 , in Purkinje cells than in ventricular myocytes. Application of 4‐aminopyridine (4‐AP, 2 mM) showed that all Purkinje cells exhibited a very substantial Ca 2+ ‐independent transient K + outward current, I t . 4‐AP significantly broadened the early, rapid repolarization phase of the action potential. Selective inhibitors of the fast component, I K,r (MK‐499, 200 nM) and the slow component I K,s (L‐735821 (propenamide), 20 nM) of the delayed rectifier K + currents both significantly lengthened the action potential, suggesting that these conductances are present, but very small (< 20 pA) in Purkinje cells. Attempts to identify time‐ and voltage‐dependent delayed rectifier K + current(s) in Purkinje cells failed, although a slow delayed rectifier was observed in ventricular myocytes. These results demonstrate significant differences in action potential waveform, and underlying K + currents in rabbit Purkinje and ventricular myocytes. Purkinje cells express a much smaller I K1 , and a larger I t than ventricular myocytes. These differences in current densities can explain some of the most important electrophysiological properties of these two tissues." @default.
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• W2129173665 date "1998-05-01" @default.
• W2129173665 modified "2023-10-16" @default.
• W2129173665 title "Repolarizing K⁺currents in rabbit heart Purkinje cells" @default.
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• W2129173665 doi "https://doi.org/10.1111/j.1469-7793.1998.811bp.x" @default.
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