Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129181330> ?p ?o ?g. }
- W2129181330 endingPage "12" @default.
- W2129181330 startingPage "7" @default.
- W2129181330 abstract "Cardiomyocyte stretching has been reported to be a major trigger for brain natriuretic peptide (BNP) release; however, an increase in circulating BNP is observed in patients with acute myocardial ischemia in the absence of increased left ventricular wall stress or cardiomyocyte stretching. In the present study, to investigate the direct and independent effects of acute myocardial ischemia on BNP expression and its mechanism, we established an in vitro glucose-free ischemia and hypoxia injured model of cultured rat cardiomyotes and proved hypoxia upregulated expressions of interleukin-6(il-6) and BNP. Further treatment with il-6 elicited dose- and time-dependent increases in BNP mRNA and protein expression as well as an upregulation in transforming growth factor-β1 (TGF-β1)/Smad2 expression, which was partially suppressed by a neutralizing antibody. In conclusion, our study showed that acute myocardial ischemia can directly upregulate BNP expression at the translational and transcriptional levels through the action of il-6, and this process is associated with the upregulation of TGF-β1/Smad2 signal path." @default.
- W2129181330 created "2016-06-24" @default.
- W2129181330 creator A5000972933 @default.
- W2129181330 creator A5051520404 @default.
- W2129181330 creator A5052076020 @default.
- W2129181330 creator A5058572669 @default.
- W2129181330 creator A5075667735 @default.
- W2129181330 date "2011-11-01" @default.
- W2129181330 modified "2023-10-17" @default.
- W2129181330 title "Acute myocardial ischemia directly modulates the expression of brain natriuretic peptide at the transcriptional and translational levels via inflammatory cytokines" @default.
- W2129181330 cites W1584596705 @default.
- W2129181330 cites W1917885463 @default.
- W2129181330 cites W1965586307 @default.
- W2129181330 cites W1969833613 @default.
- W2129181330 cites W1973829056 @default.
- W2129181330 cites W1975742635 @default.
- W2129181330 cites W1977327751 @default.
- W2129181330 cites W1998093961 @default.
- W2129181330 cites W2000463057 @default.
- W2129181330 cites W2000556566 @default.
- W2129181330 cites W2003701386 @default.
- W2129181330 cites W2011700665 @default.
- W2129181330 cites W2017557087 @default.
- W2129181330 cites W2019013025 @default.
- W2129181330 cites W2023515067 @default.
- W2129181330 cites W2029654767 @default.
- W2129181330 cites W2030383660 @default.
- W2129181330 cites W2030846416 @default.
- W2129181330 cites W2031001028 @default.
- W2129181330 cites W2031112248 @default.
- W2129181330 cites W2040227994 @default.
- W2129181330 cites W2052332638 @default.
- W2129181330 cites W2053240156 @default.
- W2129181330 cites W2062570493 @default.
- W2129181330 cites W2072819436 @default.
- W2129181330 cites W2076176291 @default.
- W2129181330 cites W2078658898 @default.
- W2129181330 cites W2089985255 @default.
- W2129181330 cites W2107359871 @default.
- W2129181330 cites W2112128648 @default.
- W2129181330 cites W2114675295 @default.
- W2129181330 cites W2118002350 @default.
- W2129181330 cites W2129812461 @default.
- W2129181330 cites W2135613041 @default.
- W2129181330 cites W2140760627 @default.
- W2129181330 cites W2167432686 @default.
- W2129181330 cites W2167504169 @default.
- W2129181330 cites W2316223190 @default.
- W2129181330 cites W2319405854 @default.
- W2129181330 cites W2347658711 @default.
- W2129181330 cites W2443773017 @default.
- W2129181330 doi "https://doi.org/10.1016/j.ejphar.2011.09.012" @default.
- W2129181330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21951964" @default.
- W2129181330 hasPublicationYear "2011" @default.
- W2129181330 type Work @default.
- W2129181330 sameAs 2129181330 @default.
- W2129181330 citedByCount "18" @default.
- W2129181330 countsByYear W21291813302012 @default.
- W2129181330 countsByYear W21291813302013 @default.
- W2129181330 countsByYear W21291813302014 @default.
- W2129181330 countsByYear W21291813302015 @default.
- W2129181330 countsByYear W21291813302016 @default.
- W2129181330 countsByYear W21291813302017 @default.
- W2129181330 countsByYear W21291813302020 @default.
- W2129181330 countsByYear W21291813302021 @default.
- W2129181330 countsByYear W21291813302022 @default.
- W2129181330 crossrefType "journal-article" @default.
- W2129181330 hasAuthorship W2129181330A5000972933 @default.
- W2129181330 hasAuthorship W2129181330A5051520404 @default.
- W2129181330 hasAuthorship W2129181330A5052076020 @default.
- W2129181330 hasAuthorship W2129181330A5058572669 @default.
- W2129181330 hasAuthorship W2129181330A5075667735 @default.
- W2129181330 hasConcept C104317684 @default.
- W2129181330 hasConcept C105580179 @default.
- W2129181330 hasConcept C126322002 @default.
- W2129181330 hasConcept C127561419 @default.
- W2129181330 hasConcept C134018914 @default.
- W2129181330 hasConcept C164705383 @default.
- W2129181330 hasConcept C178790620 @default.
- W2129181330 hasConcept C185592680 @default.
- W2129181330 hasConcept C2775846464 @default.
- W2129181330 hasConcept C2778198053 @default.
- W2129181330 hasConcept C540031477 @default.
- W2129181330 hasConcept C541997718 @default.
- W2129181330 hasConcept C55493867 @default.
- W2129181330 hasConcept C71924100 @default.
- W2129181330 hasConcept C7836513 @default.
- W2129181330 hasConceptScore W2129181330C104317684 @default.
- W2129181330 hasConceptScore W2129181330C105580179 @default.
- W2129181330 hasConceptScore W2129181330C126322002 @default.
- W2129181330 hasConceptScore W2129181330C127561419 @default.
- W2129181330 hasConceptScore W2129181330C134018914 @default.
- W2129181330 hasConceptScore W2129181330C164705383 @default.
- W2129181330 hasConceptScore W2129181330C178790620 @default.
- W2129181330 hasConceptScore W2129181330C185592680 @default.
- W2129181330 hasConceptScore W2129181330C2775846464 @default.
- W2129181330 hasConceptScore W2129181330C2778198053 @default.
- W2129181330 hasConceptScore W2129181330C540031477 @default.