Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129194911> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2129194911 abstract "Epimedium is a plant belonging to the Epimedium brevicornum Maxim species of the Berberidaceae family. The purpose of this study is to investigate the effect and pharmacological mechanism of Icarrin (ICA), which is the main component extracted from traditional Chinese Epimedium herb, on A β production in AD-like APP transgenic mice. PDAPPV717I transgenic (Tg) mice were randomly divided into model group and ICA treated (at doses 30 and 100 μmol/kg/d) groups. ICA was orally administered to Tg mice with an age range 4–10 months. The burden of Aβ was measured by ELISA and immunohistochemistry. The amyloid senile plaques were detected by Congo red staining and Bielschowsky silver staining. The expression of APP and BACE-1 were measured by applying immunohistochemistry and Western blot. The co-expression of Aβwith amyloid fibers was detected by applying double labeled immunofluorescence. Image analysis was performed with Image-pro5.0 and Image-J 7.0 software. Orally administered ICA decreased the number of amyloid senile plaques in hippocampus of Tg mice. The immunohistochemical examination of brain sections stained with polyclonal anti-Aβ antibody showed reduced A β burden, and A β levels were also decreased in the insoluble fractions of brain homogenates, as determined by ELISA. The expression of APP and BACE-1 in hippocampus was significantly decreased in ICA treated groups. ICA could reduced the A β burden and plaque deposits in the hippocampus of APP transgenic mice through depressing the expression of APP and BACE-1. Icarrin may have a promising application prospect in treatment of AD." @default.
- W2129194911 created "2016-06-24" @default.
- W2129194911 creator A5003547177 @default.
- W2129194911 date "2012-07-01" @default.
- W2129194911 modified "2023-09-25" @default.
- W2129194911 title "P4-195: Effects of Icarrin on Aβ burden in a mouse model of Alzheimer's disease" @default.
- W2129194911 doi "https://doi.org/10.1016/j.jalz.2012.05.1899" @default.
- W2129194911 hasPublicationYear "2012" @default.
- W2129194911 type Work @default.
- W2129194911 sameAs 2129194911 @default.
- W2129194911 citedByCount "0" @default.
- W2129194911 crossrefType "journal-article" @default.
- W2129194911 hasAuthorship W2129194911A5003547177 @default.
- W2129194911 hasBestOaLocation W21291949111 @default.
- W2129194911 hasConcept C102230213 @default.
- W2129194911 hasConcept C104317684 @default.
- W2129194911 hasConcept C126322002 @default.
- W2129194911 hasConcept C141035611 @default.
- W2129194911 hasConcept C142724271 @default.
- W2129194911 hasConcept C148762608 @default.
- W2129194911 hasConcept C153911025 @default.
- W2129194911 hasConcept C159654299 @default.
- W2129194911 hasConcept C185592680 @default.
- W2129194911 hasConcept C188947578 @default.
- W2129194911 hasConcept C203014093 @default.
- W2129194911 hasConcept C204232928 @default.
- W2129194911 hasConcept C204787440 @default.
- W2129194911 hasConcept C2776415932 @default.
- W2129194911 hasConcept C2779134260 @default.
- W2129194911 hasConcept C2781161787 @default.
- W2129194911 hasConcept C2781393221 @default.
- W2129194911 hasConcept C502032728 @default.
- W2129194911 hasConcept C55493867 @default.
- W2129194911 hasConcept C68026918 @default.
- W2129194911 hasConcept C71924100 @default.
- W2129194911 hasConcept C86803240 @default.
- W2129194911 hasConcept C956191 @default.
- W2129194911 hasConcept C98274493 @default.
- W2129194911 hasConceptScore W2129194911C102230213 @default.
- W2129194911 hasConceptScore W2129194911C104317684 @default.
- W2129194911 hasConceptScore W2129194911C126322002 @default.
- W2129194911 hasConceptScore W2129194911C141035611 @default.
- W2129194911 hasConceptScore W2129194911C142724271 @default.
- W2129194911 hasConceptScore W2129194911C148762608 @default.
- W2129194911 hasConceptScore W2129194911C153911025 @default.
- W2129194911 hasConceptScore W2129194911C159654299 @default.
- W2129194911 hasConceptScore W2129194911C185592680 @default.
- W2129194911 hasConceptScore W2129194911C188947578 @default.
- W2129194911 hasConceptScore W2129194911C203014093 @default.
- W2129194911 hasConceptScore W2129194911C204232928 @default.
- W2129194911 hasConceptScore W2129194911C204787440 @default.
- W2129194911 hasConceptScore W2129194911C2776415932 @default.
- W2129194911 hasConceptScore W2129194911C2779134260 @default.
- W2129194911 hasConceptScore W2129194911C2781161787 @default.
- W2129194911 hasConceptScore W2129194911C2781393221 @default.
- W2129194911 hasConceptScore W2129194911C502032728 @default.
- W2129194911 hasConceptScore W2129194911C55493867 @default.
- W2129194911 hasConceptScore W2129194911C68026918 @default.
- W2129194911 hasConceptScore W2129194911C71924100 @default.
- W2129194911 hasConceptScore W2129194911C86803240 @default.
- W2129194911 hasConceptScore W2129194911C956191 @default.
- W2129194911 hasConceptScore W2129194911C98274493 @default.
- W2129194911 hasIssue "4S_Part_19" @default.
- W2129194911 hasLocation W21291949111 @default.
- W2129194911 hasOpenAccess W2129194911 @default.
- W2129194911 hasPrimaryLocation W21291949111 @default.
- W2129194911 hasRelatedWork W2003704824 @default.
- W2129194911 hasRelatedWork W2088759808 @default.
- W2129194911 hasRelatedWork W2121263729 @default.
- W2129194911 hasRelatedWork W2315496640 @default.
- W2129194911 hasRelatedWork W2354852403 @default.
- W2129194911 hasRelatedWork W2359256335 @default.
- W2129194911 hasRelatedWork W2380130389 @default.
- W2129194911 hasRelatedWork W2394322549 @default.
- W2129194911 hasRelatedWork W2584392727 @default.
- W2129194911 hasRelatedWork W2799549251 @default.
- W2129194911 hasVolume "8" @default.
- W2129194911 isParatext "false" @default.
- W2129194911 isRetracted "false" @default.
- W2129194911 magId "2129194911" @default.
- W2129194911 workType "article" @default.