FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129208082> ?p ?o ?g. }

• W2129208082 abstract "The catecholaminergic and serotonergic neurotransmitter systems are implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). The amino acid tyrosine is the precursor for synthesis of the catecholamines dopamine and norepinephrine, while tryptophan is the precursor of serotonin. A disturbed transport of tyrosine, as well as other amino acids, has been found in a number of other psychiatric disorders, such as schizophrenia, bipolar disorder and autism, when using the fibroblast cell model. Hence, the aim of this study was to explore whether children with ADHD may have disturbed amino acid transport.Fibroblast cells were cultured from skin biopsies obtained from 14 boys diagnosed with ADHD and from 13 matching boys without a diagnosis of a developmental disorder. Transport of the amino acids tyrosine, tryptophan and alanine across the cell membrane was measured by the cluster tray method. The kinetic parameters, maximal transport capacity (V(max)) and affinity constant (K(m)) were determined. Any difference between the two groups was analyzed by Student's unpaired t-test or the Mann Whitney U test.The ADHD group had significantly decreased V(max) (p = 0.039) and K(m) (increased affinity) (p = 0.010) of tryptophan transport in comparison to controls. They also had a significantly higher V(max)of alanine transport (p = 0.031), but the Km of alanine transport did not differ significantly. There were no significant differences in any of the kinetic parameters regarding tyrosine transport in fibroblasts for the ADHD group.Tryptophan uses the same transport systems in both fibroblasts and at the blood brain barrier (BBB). Hence, a decreased transport capacity of tryptophan implies that less tryptophan is being transported across the BBB in the ADHD group. This could lead to deficient serotonin access in the brain that might cause disturbances in both the serotonergic and the catecholaminergic neurotransmitter systems, since these systems are highly interconnected. The physiological importance of an elevated transport capacity of alanine to the brain is not known to date." @default.
• W2129208082 created "2016-06-24" @default.
• W2129208082 creator A5002901976 @default.
• W2129208082 creator A5040803334 @default.
• W2129208082 creator A5045013830 @default.
• W2129208082 creator A5054694169 @default.
• W2129208082 creator A5058993443 @default.
• W2129208082 creator A5078554697 @default.
• W2129208082 creator A5091205964 @default.
• W2129208082 date "2011-09-24" @default.
• W2129208082 modified "2023-10-10" @default.
• W2129208082 title "Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study" @default.
• W2129208082 cites W140345343 @default.
• W2129208082 cites W1593109390 @default.
• W2129208082 cites W1608588255 @default.
• W2129208082 cites W1713262499 @default.
• W2129208082 cites W1944697741 @default.
• W2129208082 cites W1969908963 @default.
• W2129208082 cites W1970043120 @default.
• W2129208082 cites W1971938707 @default.
• W2129208082 cites W1982958681 @default.
• W2129208082 cites W1984658012 @default.
• W2129208082 cites W2004845096 @default.
• W2129208082 cites W2010120568 @default.
• W2129208082 cites W2010604180 @default.
• W2129208082 cites W2029429927 @default.
• W2129208082 cites W2030191099 @default.
• W2129208082 cites W2033826328 @default.
• W2129208082 cites W2034187337 @default.
• W2129208082 cites W2034194523 @default.
• W2129208082 cites W2041491921 @default.
• W2129208082 cites W2042936642 @default.
• W2129208082 cites W2050782132 @default.
• W2129208082 cites W2053984922 @default.
• W2129208082 cites W2056440800 @default.
• W2129208082 cites W2062262159 @default.
• W2129208082 cites W2067624732 @default.
• W2129208082 cites W2068590083 @default.
• W2129208082 cites W2072088359 @default.
• W2129208082 cites W2082841504 @default.
• W2129208082 cites W2084206001 @default.
• W2129208082 cites W2085959136 @default.
• W2129208082 cites W2087416407 @default.
• W2129208082 cites W2087778925 @default.
• W2129208082 cites W2090265589 @default.
• W2129208082 cites W2101738928 @default.
• W2129208082 cites W2112161820 @default.
• W2129208082 cites W2114547253 @default.
• W2129208082 cites W2125080419 @default.
• W2129208082 cites W2129219544 @default.
• W2129208082 cites W2136541538 @default.
• W2129208082 cites W2145163559 @default.
• W2129208082 cites W2149975139 @default.
• W2129208082 cites W2150399183 @default.
• W2129208082 cites W2151440675 @default.
• W2129208082 cites W2394319042 @default.
• W2129208082 cites W2401206973 @default.
• W2129208082 cites W2412516425 @default.
• W2129208082 cites W2914686075 @default.
• W2129208082 cites W4243845605 @default.
• W2129208082 cites W4293247451 @default.
• W2129208082 cites W57616982 @default.
• W2129208082 doi "https://doi.org/10.1186/1744-9081-7-40" @default.
• W2129208082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191351" @default.
• W2129208082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21942982" @default.
• W2129208082 hasPublicationYear "2011" @default.
• W2129208082 type Work @default.
• W2129208082 sameAs 2129208082 @default.
• W2129208082 citedByCount "25" @default.
• W2129208082 countsByYear W21292080822012 @default.
• W2129208082 countsByYear W21292080822013 @default.
• W2129208082 countsByYear W21292080822014 @default.
• W2129208082 countsByYear W21292080822015 @default.
• W2129208082 countsByYear W21292080822016 @default.
• W2129208082 countsByYear W21292080822017 @default.
• W2129208082 countsByYear W21292080822018 @default.
• W2129208082 countsByYear W21292080822019 @default.
• W2129208082 countsByYear W21292080822020 @default.
• W2129208082 countsByYear W21292080822021 @default.
• W2129208082 countsByYear W21292080822022 @default.
• W2129208082 countsByYear W21292080822023 @default.
• W2129208082 crossrefType "journal-article" @default.
• W2129208082 hasAuthorship W2129208082A5002901976 @default.
• W2129208082 hasAuthorship W2129208082A5040803334 @default.
• W2129208082 hasAuthorship W2129208082A5045013830 @default.
• W2129208082 hasAuthorship W2129208082A5054694169 @default.
• W2129208082 hasAuthorship W2129208082A5058993443 @default.
• W2129208082 hasAuthorship W2129208082A5078554697 @default.
• W2129208082 hasAuthorship W2129208082A5091205964 @default.
• W2129208082 hasBestOaLocation W21292080821 @default.
• W2129208082 hasConcept C118552586 @default.
• W2129208082 hasConcept C126322002 @default.
• W2129208082 hasConcept C134018914 @default.
• W2129208082 hasConcept C15744967 @default.
• W2129208082 hasConcept C170493617 @default.
• W2129208082 hasConcept C185592680 @default.
• W2129208082 hasConcept C2775864247 @default.
• W2129208082 hasConcept C2776165026 @default.
• W2129208082 hasConcept C2776706248 @default.
• W2129208082 hasConcept C2779856020 @default.

• next