FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129218640> ?p ?o ?g. }

• W2129218640 endingPage "436" @default.
• W2129218640 startingPage "431" @default.
• W2129218640 abstract "ABSTRACT. Chinese-herb nephropathy (CHN) is a rapidly progressive renal fibrosis associated with the intake of a Chinese herb (Aristolochia fangchi) containing nephrotoxic and carcinogenic aristolochic acids (AA). This study attempted to reproduce the main features of human CHN (renal failure, tubular atrophy, and interstitial fibrosis) in a rat model similar to that of cyclosporin-induced nephropathy. Salt-depleted male Wistar rats received daily subcutaneous injections of either 1 mg/kg body wt AA (low-dose AA group), 10 mg/kg body wt AA (high-dose AA group), or vehicle (control group) for 35 d. On days 10 and 35, assessment of renal function, measurements of urinary excretion of glucose, protein, and leucine aminopeptidase, and histologic analyses were performed (six rats euthanized/group). High-dose AA induced glucosuria, proteinuria, and elevated serum creatinine levels and reduced leucine aminopeptidase enzymuria on days 10 and 35, whereas low-dose AA had no significant effect. Tubular necrosis associated with lymphocytic infiltrates (day 10) and tubular atrophy surrounded by interstitial fibrosis (day 35) were the histologic findings for the high-dose AA-treated rats. In both AA groups, urothelial dysplasia was also observed, as well as fibrohistiocytic sarcoma at the injection site. A short-term model of AA-induced renal fibrosis was established in salt-depleted Wistar rats. These results support the role of AA in human CHN and provide a useful model for examination of the pathophysiologic pathways of renal fibrosis." @default.
• W2129218640 created "2016-06-24" @default.
• W2129218640 creator A5000428478 @default.
• W2129218640 creator A5010579196 @default.
• W2129218640 creator A5020180437 @default.
• W2129218640 creator A5051298410 @default.
• W2129218640 creator A5060333412 @default.
• W2129218640 creator A5062356516 @default.
• W2129218640 creator A5071554067 @default.
• W2129218640 creator A5075999585 @default.
• W2129218640 date "2002-02-01" @default.
• W2129218640 modified "2023-10-18" @default.
• W2129218640 title "Aristolochic Acids Induce Chronic Renal Failure with Interstitial Fibrosis in Salt-Depleted Rats" @default.
• W2129218640 cites W1967620364 @default.
• W2129218640 cites W1976395325 @default.
• W2129218640 cites W1999736488 @default.
• W2129218640 cites W2000053786 @default.
• W2129218640 cites W2006926854 @default.
• W2129218640 cites W2014572617 @default.
• W2129218640 cites W2022105925 @default.
• W2129218640 cites W2030533383 @default.
• W2129218640 cites W2037673603 @default.
• W2129218640 cites W2047244088 @default.
• W2129218640 cites W2061376602 @default.
• W2129218640 cites W2072750017 @default.
• W2129218640 cites W2075894028 @default.
• W2129218640 cites W2081765204 @default.
• W2129218640 cites W2090024127 @default.
• W2129218640 cites W2120221084 @default.
• W2129218640 cites W2124903568 @default.
• W2129218640 cites W2275614507 @default.
• W2129218640 cites W4293247451 @default.
• W2129218640 cites W2123489566 @default.
• W2129218640 doi "https://doi.org/10.1681/asn.v132431" @default.
• W2129218640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11805172" @default.
• W2129218640 hasPublicationYear "2002" @default.
• W2129218640 type Work @default.
• W2129218640 sameAs 2129218640 @default.
• W2129218640 citedByCount "234" @default.
• W2129218640 countsByYear W21292186402012 @default.
• W2129218640 countsByYear W21292186402013 @default.
• W2129218640 countsByYear W21292186402014 @default.
• W2129218640 countsByYear W21292186402015 @default.
• W2129218640 countsByYear W21292186402016 @default.
• W2129218640 countsByYear W21292186402017 @default.
• W2129218640 countsByYear W21292186402018 @default.
• W2129218640 countsByYear W21292186402019 @default.
• W2129218640 countsByYear W21292186402020 @default.
• W2129218640 countsByYear W21292186402021 @default.
• W2129218640 countsByYear W21292186402022 @default.
• W2129218640 countsByYear W21292186402023 @default.
• W2129218640 crossrefType "journal-article" @default.
• W2129218640 hasAuthorship W2129218640A5000428478 @default.
• W2129218640 hasAuthorship W2129218640A5010579196 @default.
• W2129218640 hasAuthorship W2129218640A5020180437 @default.
• W2129218640 hasAuthorship W2129218640A5051298410 @default.
• W2129218640 hasAuthorship W2129218640A5060333412 @default.
• W2129218640 hasAuthorship W2129218640A5062356516 @default.
• W2129218640 hasAuthorship W2129218640A5071554067 @default.
• W2129218640 hasAuthorship W2129218640A5075999585 @default.
• W2129218640 hasBestOaLocation W21292186401 @default.
• W2129218640 hasConcept C126189478 @default.
• W2129218640 hasConcept C126322002 @default.
• W2129218640 hasConcept C134018914 @default.
• W2129218640 hasConcept C142724271 @default.
• W2129218640 hasConcept C159641895 @default.
• W2129218640 hasConcept C2779561371 @default.
• W2129218640 hasConcept C2779950389 @default.
• W2129218640 hasConcept C2780026642 @default.
• W2129218640 hasConcept C2780091579 @default.
• W2129218640 hasConcept C2780306776 @default.
• W2129218640 hasConcept C2780559512 @default.
• W2129218640 hasConcept C2780813843 @default.
• W2129218640 hasConcept C2781184683 @default.
• W2129218640 hasConcept C54355233 @default.
• W2129218640 hasConcept C555293320 @default.
• W2129218640 hasConcept C71924100 @default.
• W2129218640 hasConcept C86803240 @default.
• W2129218640 hasConceptScore W2129218640C126189478 @default.
• W2129218640 hasConceptScore W2129218640C126322002 @default.
• W2129218640 hasConceptScore W2129218640C134018914 @default.
• W2129218640 hasConceptScore W2129218640C142724271 @default.
• W2129218640 hasConceptScore W2129218640C159641895 @default.
• W2129218640 hasConceptScore W2129218640C2779561371 @default.
• W2129218640 hasConceptScore W2129218640C2779950389 @default.
• W2129218640 hasConceptScore W2129218640C2780026642 @default.
• W2129218640 hasConceptScore W2129218640C2780091579 @default.
• W2129218640 hasConceptScore W2129218640C2780306776 @default.
• W2129218640 hasConceptScore W2129218640C2780559512 @default.
• W2129218640 hasConceptScore W2129218640C2780813843 @default.
• W2129218640 hasConceptScore W2129218640C2781184683 @default.
• W2129218640 hasConceptScore W2129218640C54355233 @default.
• W2129218640 hasConceptScore W2129218640C555293320 @default.
• W2129218640 hasConceptScore W2129218640C71924100 @default.
• W2129218640 hasConceptScore W2129218640C86803240 @default.
• W2129218640 hasIssue "2" @default.
• W2129218640 hasLocation W21292186401 @default.
• W2129218640 hasOpenAccess W2129218640 @default.

• next