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• W2129227881 abstract "Luotonin A is a cytotoxic alkaloid that has been shown to inhibit topoisomerase I via stabilization of the binary complex topoisomerase-DNA in the same fashion as camptothecin. The synthesis and the cytotoxic activity on the lung carcinoma cell line H460 of a series of derivatives of Luotonin A is reported. The compounds inhibit topoisomerase I but show weak cytotoxic activity, thus confirming the peculiarity of ring E of camptothecin for antitumor activity." @default.
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• W2129227881 date "2004-12-01" @default.
• W2129227881 modified "2023-09-25" @default.
• W2129227881 title "Synthesis and cytotoxic activity of substituted Luotonin A derivatives" @default.
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• W2129227881 doi "https://doi.org/10.1016/j.bmcl.2004.09.039" @default.
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