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- W2129236546 abstract "Useful only to a small minority of patients who have the procedureThere are two diametrically opposed positions on the role of sentinel lymph node biopsy in the management of patients with melanoma. Either sentinel node biopsy affords patients with the best prognostic information and biopsy followed by complete lymph node dissection provides a survival advantage for patients with intermediate thickness melanomas, or the procedures are expensive and invasive, add little or no prognostic information, and have no survival advantage. The lack of consensus is reflected in the ambiguity of guidelines internationally.1 2 3 4 5What additional prognostic information is provided by sentinel lymph node biopsy? Many studies indicate that compared with thickness, ulceration, inflammation, or mitotic rate, sentinel lymph node status is a stronger predictor of disease-free, disease specific, or overall survival,6 but we don’t know whether sentinel lymph node status alone is a better predictor of overall survival than a combination of known prognostic indicators.7 An important confounder is that knowledge of sentinel lymph node status affects patients’ subsequent treatment. People with negative results are …" @default.
- W2129236546 created "2016-06-24" @default.
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- W2129236546 date "2015-11-10" @default.
- W2129236546 modified "2023-09-27" @default.
- W2129236546 title "Sentinel lymph node biopsy in melanoma" @default.
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- W2129236546 doi "https://doi.org/10.1136/bmj.h5940" @default.
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