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- W2129248940 abstract "Association between reduced serum alpha-1 antitrypsin (?1AT) concentration and HIV infection has been reported. The possible role of ?1AT in a subset of people living with HIV who achieved control over HIV-1 disease progression without treatment has not been substantiated. We thus hypothesized that increased serum concentrations of ?1AT would be associated with control of HIV disease progression in the absence of highly antiretroviral therapy (HAART). We compared serum concentrations of ?1AT in a cross-section of HIV-1-infected subjects naive to HAART and yet resist progression to AIDS (HAART-) with those in whom control of disease progression was achieved by HAART (HAART+). Mean ?1AT concentration was significantly higher in the HAART-group (177±17mg/100mL) compared with HAART+ (126±12 mg/100mL; p=0.018). Serum ?1AT concentrations less than 100mg/100mL were found in 14% and 41% in HAART- and HAART+ group, respectively. Serum ?1ATconcentration and blood CD4+ T cells count in the HAART- group were positive correlated (R=0.426; p=0.021). Increased expression of ?1AT may contribute to effective control of HIV disease progression in the absence of HAART. Our findings support the possible use of alpha-1-antitrypsin in HIV disease management." @default.
- W2129248940 created "2016-06-24" @default.
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- W2129248940 date "2015-08-18" @default.
- W2129248940 modified "2023-09-26" @default.
- W2129248940 title "Elevated Serum Alpha-1-Antitrypsin Concentration is Associated with HIV Disease Non-Progression" @default.
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- W2129248940 doi "https://doi.org/10.15406/moji.2015.02.00046" @default.
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