Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129259620> ?p ?o ?g. }
- W2129259620 endingPage "849" @default.
- W2129259620 startingPage "838" @default.
- W2129259620 abstract "In the aging lung, the lung capacity decreases even in the absence of diseases. The progenitor cells of the distal lung, the alveolar type II cells (ATII), are essential for the repair of the gas-exchange surface. Surfactant protein production and survival of ATII cells are supported by lipofibroblasts that are peroxisome proliferator-activated receptor gamma (PPARγ)-dependent special cell type of the pulmonary tissue. PPARγ levels are directly regulated by Wnt molecules; therefore, changes in the Wnt microenvironment have close control over maintenance of the distal lung. The pulmonary aging process is associated with airspace enlargement, decrease in the distal epithelial cell compartment and infiltration of inflammatory cells. qRT–PCR analysis of purified epithelial and nonepithelial cells revealed that lipofibroblast differentiation marker parathyroid hormone-related protein receptor (PTHrPR) and PPARγ are reduced and that PPARγ reduction is regulated by Wnt4 via a β-catenin-dependent mechanism. Using a human in vitro 3D lung tissue model, a link was established between increased PPARγ and pro-surfactant protein C (pro-SPC) expression in pulmonary epithelial cells. In the senile lung, both Wnt4 and Wnt5a levels increase and both Wnt-s increase myofibroblast-like differentiation. Alteration of the Wnt microenvironment plays a significant role in pulmonary aging. Diminished lipo- and increased myofibroblast-like differentiation are directly regulated by specific Wnt-s, which process also controls surfactant production and pulmonary repair mechanisms." @default.
- W2129259620 created "2016-06-24" @default.
- W2129259620 creator A5003170394 @default.
- W2129259620 creator A5016294571 @default.
- W2129259620 creator A5017263589 @default.
- W2129259620 creator A5030361070 @default.
- W2129259620 creator A5049326416 @default.
- W2129259620 creator A5053948161 @default.
- W2129259620 creator A5056757620 @default.
- W2129259620 creator A5060933873 @default.
- W2129259620 creator A5068896520 @default.
- W2129259620 creator A5071970583 @default.
- W2129259620 date "2014-07-01" @default.
- W2129259620 modified "2023-10-13" @default.
- W2129259620 title "Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence" @default.
- W2129259620 cites W126678008 @default.
- W2129259620 cites W1567324648 @default.
- W2129259620 cites W1583292237 @default.
- W2129259620 cites W1918709511 @default.
- W2129259620 cites W1976059330 @default.
- W2129259620 cites W1987488836 @default.
- W2129259620 cites W1995497824 @default.
- W2129259620 cites W1999438839 @default.
- W2129259620 cites W2000714100 @default.
- W2129259620 cites W2003098906 @default.
- W2129259620 cites W2018762529 @default.
- W2129259620 cites W2022817365 @default.
- W2129259620 cites W2029318788 @default.
- W2129259620 cites W2029880733 @default.
- W2129259620 cites W2034021063 @default.
- W2129259620 cites W2036223112 @default.
- W2129259620 cites W2050308681 @default.
- W2129259620 cites W2058685463 @default.
- W2129259620 cites W2072832672 @default.
- W2129259620 cites W2079019573 @default.
- W2129259620 cites W2083144823 @default.
- W2129259620 cites W2084365845 @default.
- W2129259620 cites W2084881895 @default.
- W2129259620 cites W2107383519 @default.
- W2129259620 cites W2112596061 @default.
- W2129259620 cites W2113962599 @default.
- W2129259620 cites W2117918359 @default.
- W2129259620 cites W2121087466 @default.
- W2129259620 cites W2122958293 @default.
- W2129259620 cites W2124153237 @default.
- W2129259620 cites W2125963663 @default.
- W2129259620 cites W2129224957 @default.
- W2129259620 cites W2130017811 @default.
- W2129259620 cites W2135388064 @default.
- W2129259620 cites W2142781832 @default.
- W2129259620 cites W2143951787 @default.
- W2129259620 cites W2153981632 @default.
- W2129259620 cites W2162186194 @default.
- W2129259620 cites W2170331002 @default.
- W2129259620 cites W2172024195 @default.
- W2129259620 cites W4244712475 @default.
- W2129259620 doi "https://doi.org/10.1111/acel.12240" @default.
- W2129259620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4331750" @default.
- W2129259620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24981738" @default.
- W2129259620 hasPublicationYear "2014" @default.
- W2129259620 type Work @default.
- W2129259620 sameAs 2129259620 @default.
- W2129259620 citedByCount "35" @default.
- W2129259620 countsByYear W21292596202014 @default.
- W2129259620 countsByYear W21292596202015 @default.
- W2129259620 countsByYear W21292596202016 @default.
- W2129259620 countsByYear W21292596202017 @default.
- W2129259620 countsByYear W21292596202018 @default.
- W2129259620 countsByYear W21292596202019 @default.
- W2129259620 countsByYear W21292596202020 @default.
- W2129259620 countsByYear W21292596202021 @default.
- W2129259620 countsByYear W21292596202022 @default.
- W2129259620 crossrefType "journal-article" @default.
- W2129259620 hasAuthorship W2129259620A5003170394 @default.
- W2129259620 hasAuthorship W2129259620A5016294571 @default.
- W2129259620 hasAuthorship W2129259620A5017263589 @default.
- W2129259620 hasAuthorship W2129259620A5030361070 @default.
- W2129259620 hasAuthorship W2129259620A5049326416 @default.
- W2129259620 hasAuthorship W2129259620A5053948161 @default.
- W2129259620 hasAuthorship W2129259620A5056757620 @default.
- W2129259620 hasAuthorship W2129259620A5060933873 @default.
- W2129259620 hasAuthorship W2129259620A5068896520 @default.
- W2129259620 hasAuthorship W2129259620A5071970583 @default.
- W2129259620 hasBestOaLocation W21292596202 @default.
- W2129259620 hasConcept C126322002 @default.
- W2129259620 hasConcept C134018914 @default.
- W2129259620 hasConcept C137620995 @default.
- W2129259620 hasConcept C170493617 @default.
- W2129259620 hasConcept C201750760 @default.
- W2129259620 hasConcept C207865475 @default.
- W2129259620 hasConcept C2777714996 @default.
- W2129259620 hasConcept C2780176071 @default.
- W2129259620 hasConcept C2780559512 @default.
- W2129259620 hasConcept C2781430442 @default.
- W2129259620 hasConcept C28328180 @default.
- W2129259620 hasConcept C502942594 @default.
- W2129259620 hasConcept C55493867 @default.
- W2129259620 hasConcept C60870556 @default.