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- W212927979 abstract "This chapter presents a framework of results showing that a host bearing a progressive immunogenic tumor responds immunologically to its tumor by generating a state of concomitant antitumor immunity. Because a host with an already established tumor represent the real situation that a therapist is confronted with, the possible possession by the host of a state of concomitant immunity would need to be considered in any attempt to cause regression of the tumor be immunotherapy. The results presented in this chapter leave little doubt that a syngeneic host can generate an immune response against its immunogenic tumor, but that the response is “down-regulated” by suppressor T cells before enough effector T cells are generated to destroy the tumor. This conclusion is based on the results of two main lines of investigation that involved the use of an adoptive immunization model illustrated diagrammatically. The chapter argues that an analysis of the generation and decay of concomitant immunity is essential for an understanding of why immunogenic tumors grow progressively in their immunocompetent hosts and why these tumors fail to regress in response to active or passive immunotherapy." @default.
- W212927979 created "2016-06-24" @default.
- W212927979 creator A5007179531 @default.
- W212927979 date "1984-01-01" @default.
- W212927979 modified "2023-10-03" @default.
- W212927979 title "The Murine Antitumor Immune Response and Its Therapeutic Manipulation" @default.
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- W212927979 doi "https://doi.org/10.1016/s0065-2776(08)60575-1" @default.
- W212927979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6235727" @default.
- W212927979 hasPublicationYear "1984" @default.
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