FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129280374> ?p ?o ?g. }

• W2129280374 endingPage "921" @default.
• W2129280374 startingPage "915" @default.
• W2129280374 abstract "At present, more than 75% of routine nuclear medicine diagnostic procedures use technetium-99m (99mTc). The binding between 99mTc and the drug to obtain the radiopharmaceutical needs a reducing agent, with stannous chloride (SnCl2) being one of the most used. There are controversies about the cytotoxic, genotoxic and mutagenic effects of SnCl2 in the literature. Thus, the approaches below were used to better understand the biological effects of this salt and its association in nuclear medicine kits [methylenediphosphonate (MDP) bone scintigraphy and diethylenetriaminepentaacetic acid (DTPA) kidney and brain scintigraphy]: (i) bacterial inactivation experiments; (ii) agarose gel electrophoresis of supercoiled and linear plasmid DNA and (iii) bacterial transformation assay. The Escherichia coli strains used here were AB1157 (wild type) and BW9091 (xthA mutant). Data obtained showed that both MDP and SnCl2 presented a high toxicity, but this was not observed when they were assayed together in the kit, thereby displaying a mutual protect effect. DTPA salt showed a moderate toxicity, and once more, the DTPA kit provided protection, compared to the SnCl2 effect alone. The results suggest a possible complex formation, either MDP-SnCl2 or DTPA-SnCl2, originating an atoxic compound. On the other hand, SnCl2-induced cell inactivation and the decrease in bacterial transformation generated by DTPA found in XthA mutant strain suggest that the lack of this enzyme could be responsible for the effects observed, being necessary to induce DNA damage repair." @default.
• W2129280374 created "2016-06-24" @default.
• W2129280374 creator A5003977231 @default.
• W2129280374 creator A5017296710 @default.
• W2129280374 creator A5047366441 @default.
• W2129280374 creator A5054302099 @default.
• W2129280374 creator A5060366198 @default.
• W2129280374 creator A5066575274 @default.
• W2129280374 creator A5070444300 @default.
• W2129280374 creator A5088228106 @default.
• W2129280374 date "2006-10-01" @default.
• W2129280374 modified "2023-09-27" @default.
• W2129280374 title "Cytotoxic and genotoxic effects induced by stannous chloride associated to nuclear medicine kits" @default.
• W2129280374 cites W126024904 @default.
• W2129280374 cites W1546472725 @default.
• W2129280374 cites W1603937307 @default.
• W2129280374 cites W1715183534 @default.
• W2129280374 cites W1878364547 @default.
• W2129280374 cites W1971977063 @default.
• W2129280374 cites W1978870715 @default.
• W2129280374 cites W1985632161 @default.
• W2129280374 cites W1987339872 @default.
• W2129280374 cites W1990785025 @default.
• W2129280374 cites W1994613507 @default.
• W2129280374 cites W2003970963 @default.
• W2129280374 cites W2006676188 @default.
• W2129280374 cites W2015251470 @default.
• W2129280374 cites W2017564717 @default.
• W2129280374 cites W2022624962 @default.
• W2129280374 cites W2025528877 @default.
• W2129280374 cites W2028339495 @default.
• W2129280374 cites W2040627045 @default.
• W2129280374 cites W2044688939 @default.
• W2129280374 cites W2047003405 @default.
• W2129280374 cites W2048590032 @default.
• W2129280374 cites W2054970021 @default.
• W2129280374 cites W2086374634 @default.
• W2129280374 cites W2091710487 @default.
• W2129280374 cites W2092998226 @default.
• W2129280374 cites W2095323718 @default.
• W2129280374 cites W2118633304 @default.
• W2129280374 cites W2132417094 @default.
• W2129280374 cites W2150765956 @default.
• W2129280374 cites W2160828503 @default.
• W2129280374 doi "https://doi.org/10.1016/j.nucmedbio.2006.07.008" @default.
• W2129280374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17045172" @default.
• W2129280374 hasPublicationYear "2006" @default.
• W2129280374 type Work @default.
• W2129280374 sameAs 2129280374 @default.
• W2129280374 citedByCount "18" @default.
• W2129280374 countsByYear W21292803742012 @default.
• W2129280374 countsByYear W21292803742014 @default.
• W2129280374 countsByYear W21292803742015 @default.
• W2129280374 countsByYear W21292803742020 @default.
• W2129280374 countsByYear W21292803742021 @default.
• W2129280374 crossrefType "journal-article" @default.
• W2129280374 hasAuthorship W2129280374A5003977231 @default.
• W2129280374 hasAuthorship W2129280374A5017296710 @default.
• W2129280374 hasAuthorship W2129280374A5047366441 @default.
• W2129280374 hasAuthorship W2129280374A5054302099 @default.
• W2129280374 hasAuthorship W2129280374A5060366198 @default.
• W2129280374 hasAuthorship W2129280374A5066575274 @default.
• W2129280374 hasAuthorship W2129280374A5070444300 @default.
• W2129280374 hasAuthorship W2129280374A5088228106 @default.
• W2129280374 hasConcept C104317684 @default.
• W2129280374 hasConcept C13965031 @default.
• W2129280374 hasConcept C143065580 @default.
• W2129280374 hasConcept C153911025 @default.
• W2129280374 hasConcept C154317977 @default.
• W2129280374 hasConcept C178790620 @default.
• W2129280374 hasConcept C185592680 @default.
• W2129280374 hasConcept C197404232 @default.
• W2129280374 hasConcept C202751555 @default.
• W2129280374 hasConcept C2778271344 @default.
• W2129280374 hasConcept C2778695967 @default.
• W2129280374 hasConcept C29730261 @default.
• W2129280374 hasConcept C522557706 @default.
• W2129280374 hasConcept C547475151 @default.
• W2129280374 hasConcept C552990157 @default.
• W2129280374 hasConcept C55493867 @default.
• W2129280374 hasConcept C86803240 @default.
• W2129280374 hasConceptScore W2129280374C104317684 @default.
• W2129280374 hasConceptScore W2129280374C13965031 @default.
• W2129280374 hasConceptScore W2129280374C143065580 @default.
• W2129280374 hasConceptScore W2129280374C153911025 @default.
• W2129280374 hasConceptScore W2129280374C154317977 @default.
• W2129280374 hasConceptScore W2129280374C178790620 @default.
• W2129280374 hasConceptScore W2129280374C185592680 @default.
• W2129280374 hasConceptScore W2129280374C197404232 @default.
• W2129280374 hasConceptScore W2129280374C202751555 @default.
• W2129280374 hasConceptScore W2129280374C2778271344 @default.
• W2129280374 hasConceptScore W2129280374C2778695967 @default.
• W2129280374 hasConceptScore W2129280374C29730261 @default.
• W2129280374 hasConceptScore W2129280374C522557706 @default.
• W2129280374 hasConceptScore W2129280374C547475151 @default.
• W2129280374 hasConceptScore W2129280374C552990157 @default.
• W2129280374 hasConceptScore W2129280374C55493867 @default.
• W2129280374 hasConceptScore W2129280374C86803240 @default.

• next