FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129286058> ?p ?o ?g. }

• W2129286058 endingPage "474" @default.
• W2129286058 startingPage "468" @default.
• W2129286058 abstract "<h3>Background</h3> Recent findings in mouse models suggest that T helper (Th)17 cells, characterised by production of interleukin (IL)-17A and IL-22, are involved in the immunopathogenesis of pneumonia. <h3>Objective</h3> In this study, we aimed to identify the involvement of Th17 cells in human community-acquired pneumonia (CAP). <h3>Design</h3> Within 24 h of admission, T cells from peripheral blood (n=39) and bronchoalveolar lavage (BAL, n=20) of CAP patients and of 10 healthy individuals were analysed by intracellular flow cytometry for the production of various cytokines, including IL-17A and IL-22. Peripheral blood T cells were also analysed 7 and 30 days after admission. Th17 cytokine profiles were correlated with pneumonia severity index and microbial aetiology. <h3>Results</h3> In the BAL of CAP patients, proportions of IL-17A and IL-22 single positive, as well as IL-17A/IL-22 double positive CD4 T cells were significantly increased compared with healthy individuals. Significantly increased proportions of IL-17A/IL-22 double positive CD4 T cells in BAL were found in non-severe and severe CAP patients, as well as in pneumococcal and non-pneumococcal CAP. In the peripheral blood of CAP patients upon admission, we found significantly increased proportions of IL-17A/IL-22 double positive CD4 T cells. One week after admission, the proportions of these double positive cells were still significantly increased in CAP patients compared with healthy individuals. <h3>Conclusions</h3> These data indicate that Th17 cells are engaged in the local and systemic immune response in human pneumonia. Especially, IL-17A/IL-22 double positive Th17 cells may be involved in the immunopathogenesis of CAP." @default.
• W2129286058 created "2016-06-24" @default.
• W2129286058 creator A5005308154 @default.
• W2129286058 creator A5030061739 @default.
• W2129286058 creator A5032626967 @default.
• W2129286058 creator A5038717099 @default.
• W2129286058 creator A5039614861 @default.
• W2129286058 creator A5043916295 @default.
• W2129286058 creator A5051066209 @default.
• W2129286058 creator A5065427050 @default.
• W2129286058 creator A5068095052 @default.
• W2129286058 date "2013-01-12" @default.
• W2129286058 modified "2023-10-15" @default.
• W2129286058 title "T helper 17 cells are involved in the local and systemic inflammatory response in community-acquired pneumonia" @default.
• W2129286058 cites W1884169158 @default.
• W2129286058 cites W1964052073 @default.
• W2129286058 cites W1987628377 @default.
• W2129286058 cites W1993072895 @default.
• W2129286058 cites W1994182162 @default.
• W2129286058 cites W2004186675 @default.
• W2129286058 cites W2030386172 @default.
• W2129286058 cites W2035984614 @default.
• W2129286058 cites W2041693925 @default.
• W2129286058 cites W2060616257 @default.
• W2129286058 cites W2061868430 @default.
• W2129286058 cites W2076893605 @default.
• W2129286058 cites W2081386448 @default.
• W2129286058 cites W2093501061 @default.
• W2129286058 cites W2098315859 @default.
• W2129286058 cites W2106539209 @default.
• W2129286058 cites W2112331687 @default.
• W2129286058 cites W2113861222 @default.
• W2129286058 cites W2114539533 @default.
• W2129286058 cites W2125573161 @default.
• W2129286058 cites W2126723350 @default.
• W2129286058 cites W2128278081 @default.
• W2129286058 cites W2128721558 @default.
• W2129286058 cites W2130959939 @default.
• W2129286058 cites W2137051908 @default.
• W2129286058 cites W2139008734 @default.
• W2129286058 cites W2154676602 @default.
• W2129286058 cites W2159542223 @default.
• W2129286058 cites W2160883911 @default.
• W2129286058 cites W2168416712 @default.
• W2129286058 cites W2172094131 @default.
• W2129286058 doi "https://doi.org/10.1136/thoraxjnl-2012-202168" @default.
• W2129286058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23315492" @default.
• W2129286058 hasPublicationYear "2013" @default.
• W2129286058 type Work @default.
• W2129286058 sameAs 2129286058 @default.
• W2129286058 citedByCount "34" @default.
• W2129286058 countsByYear W21292860582013 @default.
• W2129286058 countsByYear W21292860582014 @default.
• W2129286058 countsByYear W21292860582015 @default.
• W2129286058 countsByYear W21292860582016 @default.
• W2129286058 countsByYear W21292860582017 @default.
• W2129286058 countsByYear W21292860582018 @default.
• W2129286058 countsByYear W21292860582019 @default.
• W2129286058 countsByYear W21292860582020 @default.
• W2129286058 countsByYear W21292860582021 @default.
• W2129286058 countsByYear W21292860582023 @default.
• W2129286058 crossrefType "journal-article" @default.
• W2129286058 hasAuthorship W2129286058A5005308154 @default.
• W2129286058 hasAuthorship W2129286058A5030061739 @default.
• W2129286058 hasAuthorship W2129286058A5032626967 @default.
• W2129286058 hasAuthorship W2129286058A5038717099 @default.
• W2129286058 hasAuthorship W2129286058A5039614861 @default.
• W2129286058 hasAuthorship W2129286058A5043916295 @default.
• W2129286058 hasAuthorship W2129286058A5051066209 @default.
• W2129286058 hasAuthorship W2129286058A5065427050 @default.
• W2129286058 hasAuthorship W2129286058A5068095052 @default.
• W2129286058 hasBestOaLocation W21292860581 @default.
• W2129286058 hasConcept C126322002 @default.
• W2129286058 hasConcept C203014093 @default.
• W2129286058 hasConcept C2777714996 @default.
• W2129286058 hasConcept C2777914695 @default.
• W2129286058 hasConcept C2777961210 @default.
• W2129286058 hasConcept C2778690821 @default.
• W2129286058 hasConcept C2779892413 @default.
• W2129286058 hasConcept C2781253189 @default.
• W2129286058 hasConcept C501593827 @default.
• W2129286058 hasConcept C50345908 @default.
• W2129286058 hasConcept C553184892 @default.
• W2129286058 hasConcept C68324877 @default.
• W2129286058 hasConcept C71924100 @default.
• W2129286058 hasConcept C74172505 @default.
• W2129286058 hasConcept C86803240 @default.
• W2129286058 hasConcept C89423630 @default.
• W2129286058 hasConceptScore W2129286058C126322002 @default.
• W2129286058 hasConceptScore W2129286058C203014093 @default.
• W2129286058 hasConceptScore W2129286058C2777714996 @default.
• W2129286058 hasConceptScore W2129286058C2777914695 @default.
• W2129286058 hasConceptScore W2129286058C2777961210 @default.
• W2129286058 hasConceptScore W2129286058C2778690821 @default.
• W2129286058 hasConceptScore W2129286058C2779892413 @default.
• W2129286058 hasConceptScore W2129286058C2781253189 @default.
• W2129286058 hasConceptScore W2129286058C501593827 @default.
• W2129286058 hasConceptScore W2129286058C50345908 @default.

• next