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- W2129291267 abstract "The present study was performed to establish the intrinsic frequency of the slow waves in different regions of the cat stomach, to define the propagation velocity of the slow wave along the stomach, and to determine whether endogenous prostaglandins can affect the slow wave frequency. In 20 cats, electrical activity was recorded from the anterior wall of the intact stomach in vivo and in vitro, and in vitro after cutting the stomach into 16 pieces to isolate each pair of electrodes. In vivo, slow waves (4.1 ± 0.5 cpm) were seen only from mid corpus to pylorus, the apparent propagation velocity decreasing towards the antrum. In vitro: (a) after cutting, the slow wave frequency increased, to a maximum in 1 h (12 ± 1.8 cpm; range 10.2–17.3), with the highest frequency always in the mid or orad corpus, usually on the greater curvature (GC), (b) with indomethacin (10−5M) the increase in slow wave frequency was prevented or reversed, and there was a frequency gradient with the highest frequency (4.4 ± 1.2 cpm) uniformly located in the most proximal active site on the GC, and (c) slow waves on the GC were more stable, regular and continuous than on the lesser curvature (LC), the difference being most evident in the corpus. The results suggest that the cat stomach behaves as a system of electrically coupled oscillators of different frequencies. The dominant oscillator of highest frequency is situated in the proximal corpus of the GC, with the remainder of the distal stomach entrained at this frequency. All gastric slow wave oscillators can be driven to higher frequencies by endogenous prostaglandins. The decreasing velocity of slow wave propagation distally suggests that oscillator properties and/or coupling among oscillators differs in the cat." @default.
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- W2129291267 date "1995-09-01" @default.
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- W2129291267 title "Electrical slow wave activity of the cat stomach: its frequency gradient and the effect of indomethacin" @default.
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- W2129291267 doi "https://doi.org/10.1111/j.1365-2982.1995.tb00221.x" @default.
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