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- W2129297243 abstract "Introduction The endothelial protein C receptor (EPCR) mediates coagulation and inflammation. Early rise of circulating soluble (s)EPCR levels has been shown to correlate with poor outcome in critically-ill patients with severe sepsis (Guitton et al . Intensive Care Med 2011; 37: 950-6); yet potential associations of sEPCR measured early post ICU admission with subsequent sepsis development are still unknown. Aims To investigate if sEPCR plasma levels of critically-ill subjects at ICU admission predict sepsis development. Methods 59 critically-ill patients suffering from medical, surgical and trauma-related pathologies were included in the study. Circulating sEPCR levels were measured ≤24h post ICU admission; all patients were free of sepsis. Demographics, APACHE II & SOFA scores were recorded and circulating PCT & CRP were measured. Results From the initial cohort, 30 patients subsequently developed sepsis and 29 did not. SOFA score (mean±SD: 6.4±2.7) and sEPCR levels (median & IQR: 173.4 (104.5-223.5) ng/mL) were significantly higher in the subsequent sepsis group as compared to the non sepsis group (5±2.3, p=0.037, and 98.3 (69.8-147.7) p=0.004, respectively). ICU mortality and PCT tended to be higher in the sepsis group. Cox regression analysis identified sEPCR as the only parameter related to sepsis development with time (RR: 1.078 & 95% CI: 1.016-1.144, by 10 sEPCR units, p=0.013). When the whole cohort was dichotomized above (≥139.5) and below the sEPCR median ( Conclusions In our cohort, high sEPCR plasma levels at ICU admission (i.e. ≤24h) predict sepsis development." @default.
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- W2129297243 date "2012-09-01" @default.
- W2129297243 modified "2023-09-27" @default.
- W2129297243 title "Elevated plasma EPCR levels early post ICU admission predict sepsis development" @default.
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