FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129302035> ?p ?o ?g. }

• W2129302035 endingPage "G1180" @default.
• W2129302035 startingPage "G1172" @default.
• W2129302035 abstract "Despite its position at the front line against ingested pathogens, very little is presently known about the role of the esophageal epithelium in host innate immune defense. As a key player in the innate immune response, Toll-like receptor (TLR) signaling has not been well characterized in human esophageal epithelial cells. In the present study, we investigated the inflammatory response and signaling pathways activated by TLR stimulation of human esophageal cells in vitro. Using quantitative RT-PCR, we profiled the expression pattern of human TLRs 1–10 in primary esophageal keratinocytes (EPC2), immortalized nontransformed esophageal keratinocytes (EPC2-hTERT), and normal human esophageal mucosal biopsies and found that TLRs 1, 2, 3, and 5 were expressed both in vivo and in vitro. Using the cytokine IL-8 as a physiological read out of the inflammatory response, we found that TLR3 is the most functional of the expressed TLRs in both primary and immortalized esophageal epithelial cell lines in response to its synthetic ligand polyinosinic polycytidylic acid [poly(I:C)]. Through reporter gene studies, we show that poly(I:C)-induced NF-κB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-κB occurs at an early time point following poly(I:C) stimulation of esophageal epithelial cells. Importantly, we also show that poly(I:C) stimulation induces the NF-κB-dependent esophageal epithelial expression of TLR2, leading to enhanced epithelial responsiveness of EPC2-hTERT cells to TLR2 ligand stimulation, suggesting an important regulatory role for TLR3-mediated NF-κB signaling in the innate immune response of esophageal epithelial cells. Our findings demonstrate for the first time that TLR3 is highly functional in the human esophageal epithelium and that TLR3-mediated NF-κB signaling may play an important regulatory role in esophageal epithelial homeostasis." @default.
• W2129302035 created "2016-06-24" @default.
• W2129302035 creator A5008131092 @default.
• W2129302035 creator A5008531435 @default.
• W2129302035 creator A5068648470 @default.
• W2129302035 creator A5078963433 @default.
• W2129302035 date "2009-12-01" @default.
• W2129302035 modified "2023-10-16" @default.
• W2129302035 title "TLR3-mediated NF-κB signaling in human esophageal epithelial cells" @default.
• W2129302035 cites W1544940894 @default.
• W2129302035 cites W1595790490 @default.
• W2129302035 cites W1902083634 @default.
• W2129302035 cites W1950448919 @default.
• W2129302035 cites W1969072247 @default.
• W2129302035 cites W1969202621 @default.
• W2129302035 cites W1974545869 @default.
• W2129302035 cites W1977284578 @default.
• W2129302035 cites W1979495148 @default.
• W2129302035 cites W1983359495 @default.
• W2129302035 cites W1984616248 @default.
• W2129302035 cites W1986178107 @default.
• W2129302035 cites W1990847452 @default.
• W2129302035 cites W1995073019 @default.
• W2129302035 cites W2005530726 @default.
• W2129302035 cites W2007811208 @default.
• W2129302035 cites W2010156274 @default.
• W2129302035 cites W2011781801 @default.
• W2129302035 cites W2012178533 @default.
• W2129302035 cites W2013329696 @default.
• W2129302035 cites W2034807293 @default.
• W2129302035 cites W2040749046 @default.
• W2129302035 cites W2046056065 @default.
• W2129302035 cites W2046454404 @default.
• W2129302035 cites W2046649601 @default.
• W2129302035 cites W2047194856 @default.
• W2129302035 cites W2051831012 @default.
• W2129302035 cites W2054465223 @default.
• W2129302035 cites W2059213579 @default.
• W2129302035 cites W2060629187 @default.
• W2129302035 cites W2062654253 @default.
• W2129302035 cites W2064229941 @default.
• W2129302035 cites W2066420604 @default.
• W2129302035 cites W2067662036 @default.
• W2129302035 cites W2076361525 @default.
• W2129302035 cites W2082400500 @default.
• W2129302035 cites W2092237732 @default.
• W2129302035 cites W2101363646 @default.
• W2129302035 cites W2106877484 @default.
• W2129302035 cites W2108548328 @default.
• W2129302035 cites W2108596257 @default.
• W2129302035 cites W2110223162 @default.
• W2129302035 cites W2112135370 @default.
• W2129302035 cites W2113577317 @default.
• W2129302035 cites W2126327372 @default.
• W2129302035 cites W2131596612 @default.
• W2129302035 cites W2133439754 @default.
• W2129302035 cites W2141137217 @default.
• W2129302035 cites W2142541950 @default.
• W2129302035 cites W2146807706 @default.
• W2129302035 cites W2147923982 @default.
• W2129302035 cites W2154888801 @default.
• W2129302035 cites W2167187379 @default.
• W2129302035 cites W2167215692 @default.
• W2129302035 cites W4246254039 @default.
• W2129302035 doi "https://doi.org/10.1152/ajpgi.00065.2009" @default.
• W2129302035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2850089" @default.
• W2129302035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19779021" @default.
• W2129302035 hasPublicationYear "2009" @default.
• W2129302035 type Work @default.
• W2129302035 sameAs 2129302035 @default.
• W2129302035 citedByCount "51" @default.
• W2129302035 countsByYear W21293020352012 @default.
• W2129302035 countsByYear W21293020352013 @default.
• W2129302035 countsByYear W21293020352014 @default.
• W2129302035 countsByYear W21293020352015 @default.
• W2129302035 countsByYear W21293020352016 @default.
• W2129302035 countsByYear W21293020352017 @default.
• W2129302035 countsByYear W21293020352018 @default.
• W2129302035 countsByYear W21293020352019 @default.
• W2129302035 countsByYear W21293020352020 @default.
• W2129302035 countsByYear W21293020352021 @default.
• W2129302035 countsByYear W21293020352022 @default.
• W2129302035 countsByYear W21293020352023 @default.
• W2129302035 crossrefType "journal-article" @default.
• W2129302035 hasAuthorship W2129302035A5008131092 @default.
• W2129302035 hasAuthorship W2129302035A5008531435 @default.
• W2129302035 hasAuthorship W2129302035A5068648470 @default.
• W2129302035 hasAuthorship W2129302035A5078963433 @default.
• W2129302035 hasBestOaLocation W21293020352 @default.
• W2129302035 hasConcept C104317684 @default.
• W2129302035 hasConcept C1292079 @default.
• W2129302035 hasConcept C136449434 @default.
• W2129302035 hasConcept C203014093 @default.
• W2129302035 hasConcept C2776070231 @default.
• W2129302035 hasConcept C2776709828 @default.
• W2129302035 hasConcept C2778420691 @default.
• W2129302035 hasConcept C2781236682 @default.
• W2129302035 hasConcept C502942594 @default.

• next