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• W2129303921 startingPage "3541" @default.
• W2129303921 abstract "TFIIH is a multisubunit complex, containing ATPase, helicases, and kinase activities. Functionally, TFIIH has been implicated in transcription by RNA polymerase II (RNAPII) and in nucleotide excision repair. A member of the cyclin-dependent kinase family, CDK7, is the kinase subunit of TFIIH. Genetically, CDK7 homologues have been implicated in transcription in Saccharomyces cerevisiae, and in mitotic regulation in Schizosaccharomyces pombe. Here we show that in mitosis the CDK7 subunit of TFIIH and the largest subunit of RNAPII become hyperphosphorylated. MPF-induced phosphorylation of CDK7 results in inhibition of the TFIIH-associated kinase and transcription activities. Negative and positive regulation of TFIIH requires phosphorylation within the T-loop of CDK7. Our data establishes TFIIH and its subunit CDK7 as a direct link between the regulation of transcription and the cell cycle." @default.
• W2129303921 created "2016-06-24" @default.
• W2129303921 creator A5016384926 @default.
• W2129303921 creator A5054806388 @default.
• W2129303921 date "1998-11-15" @default.
• W2129303921 modified "2023-10-13" @default.
• W2129303921 title "The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7" @default.
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• W2129303921 doi "https://doi.org/10.1101/gad.12.22.3541" @default.
• W2129303921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/317239" @default.
• W2129303921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9832506" @default.
• W2129303921 hasPublicationYear "1998" @default.
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