Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129308384> ?p ?o ?g. }
- W2129308384 endingPage "L897" @default.
- W2129308384 startingPage "L887" @default.
- W2129308384 abstract "The response of alveolar epithelial cells (AECs) to lung injury plays a central role in the pathogenesis of pulmonary fibrosis, but the mechanisms by which AECs regulate fibrotic processes are not well defined. We aimed to elucidate how transforming growth factor-β (TGFβ) signaling in lung epithelium impacts lung fibrosis in the intratracheal bleomycin model. Mice with selective deficiency of TGFβ receptor 2 (TGFβR2) in lung epithelium were generated and crossed to cell fate reporter mice that express β-galactosidase (β-gal) in cells of lung epithelial lineage. Mice were given intratracheal bleomycin (0.08 U), and the following parameters were assessed: AEC death by terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling assay, inflammation by total and differential cell counts from bronchoalveolar lavage, fibrosis by scoring of trichrome-stained lung sections, and total lung collagen content. Mice with lung epithelial deficiency of TGFβR2 had improved AEC survival, despite greater lung inflammation, after bleomycin administration. At 3 wk after bleomycin administration, mice with epithelial TGFβR2 deficiency showed a significantly attenuated fibrotic response in the lungs, as determined by semiquantitatve scoring and total collagen content. The reduction in lung fibrosis in these mice was associated with a marked decrease in the lung fibroblast population, both total lung fibroblasts and epithelial-to-mesenchymal transition-derived (S100A4 + /β-gal + ) fibroblasts. Attenuation of TGFβ signaling in lung epithelium provides protection from bleomycin-induced fibrosis, indicating a critical role for the epithelium in transducing the profibrotic effects of this cytokine." @default.
- W2129308384 created "2016-06-24" @default.
- W2129308384 creator A5004036191 @default.
- W2129308384 creator A5007902859 @default.
- W2129308384 creator A5011724465 @default.
- W2129308384 creator A5012772335 @default.
- W2129308384 creator A5038385346 @default.
- W2129308384 creator A5041573761 @default.
- W2129308384 creator A5063872240 @default.
- W2129308384 creator A5065266088 @default.
- W2129308384 creator A5078133108 @default.
- W2129308384 creator A5084201757 @default.
- W2129308384 creator A5089266556 @default.
- W2129308384 creator A5090645846 @default.
- W2129308384 date "2011-06-01" @default.
- W2129308384 modified "2023-09-26" @default.
- W2129308384 title "TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment" @default.
- W2129308384 cites W1498451757 @default.
- W2129308384 cites W1597039738 @default.
- W2129308384 cites W1636022999 @default.
- W2129308384 cites W1663371441 @default.
- W2129308384 cites W1703021606 @default.
- W2129308384 cites W1768274470 @default.
- W2129308384 cites W1768877551 @default.
- W2129308384 cites W1967370559 @default.
- W2129308384 cites W1975365084 @default.
- W2129308384 cites W1987361483 @default.
- W2129308384 cites W1989044835 @default.
- W2129308384 cites W1992938929 @default.
- W2129308384 cites W1994738588 @default.
- W2129308384 cites W1996883499 @default.
- W2129308384 cites W1996965076 @default.
- W2129308384 cites W1998975199 @default.
- W2129308384 cites W2000708019 @default.
- W2129308384 cites W2006118136 @default.
- W2129308384 cites W2009639116 @default.
- W2129308384 cites W2013998980 @default.
- W2129308384 cites W2018809578 @default.
- W2129308384 cites W2019431738 @default.
- W2129308384 cites W2025029681 @default.
- W2129308384 cites W2031300004 @default.
- W2129308384 cites W2038607574 @default.
- W2129308384 cites W2046501504 @default.
- W2129308384 cites W2059978214 @default.
- W2129308384 cites W2060126259 @default.
- W2129308384 cites W2060928333 @default.
- W2129308384 cites W2079517510 @default.
- W2129308384 cites W2082429467 @default.
- W2129308384 cites W2082744052 @default.
- W2129308384 cites W2104162762 @default.
- W2129308384 cites W2115469285 @default.
- W2129308384 cites W2128571355 @default.
- W2129308384 cites W2130616801 @default.
- W2129308384 cites W2133284260 @default.
- W2129308384 cites W2133699487 @default.
- W2129308384 cites W2134664605 @default.
- W2129308384 cites W2136114918 @default.
- W2129308384 cites W2136592357 @default.
- W2129308384 cites W2143188326 @default.
- W2129308384 cites W2145472547 @default.
- W2129308384 cites W2145489141 @default.
- W2129308384 cites W2148738605 @default.
- W2129308384 cites W2150268403 @default.
- W2129308384 cites W2150639372 @default.
- W2129308384 cites W2154733572 @default.
- W2129308384 cites W2155139007 @default.
- W2129308384 cites W2158847399 @default.
- W2129308384 cites W2168228140 @default.
- W2129308384 cites W2229805806 @default.
- W2129308384 cites W2626588662 @default.
- W2129308384 cites W4250731522 @default.
- W2129308384 doi "https://doi.org/10.1152/ajplung.00397.2010" @default.
- W2129308384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3119129" @default.
- W2129308384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21441353" @default.
- W2129308384 hasPublicationYear "2011" @default.
- W2129308384 type Work @default.
- W2129308384 sameAs 2129308384 @default.
- W2129308384 citedByCount "70" @default.
- W2129308384 countsByYear W21293083842012 @default.
- W2129308384 countsByYear W21293083842013 @default.
- W2129308384 countsByYear W21293083842014 @default.
- W2129308384 countsByYear W21293083842015 @default.
- W2129308384 countsByYear W21293083842016 @default.
- W2129308384 countsByYear W21293083842017 @default.
- W2129308384 countsByYear W21293083842018 @default.
- W2129308384 countsByYear W21293083842019 @default.
- W2129308384 countsByYear W21293083842020 @default.
- W2129308384 countsByYear W21293083842021 @default.
- W2129308384 countsByYear W21293083842022 @default.
- W2129308384 countsByYear W21293083842023 @default.
- W2129308384 crossrefType "journal-article" @default.
- W2129308384 hasAuthorship W2129308384A5004036191 @default.
- W2129308384 hasAuthorship W2129308384A5007902859 @default.
- W2129308384 hasAuthorship W2129308384A5011724465 @default.
- W2129308384 hasAuthorship W2129308384A5012772335 @default.
- W2129308384 hasAuthorship W2129308384A5038385346 @default.
- W2129308384 hasAuthorship W2129308384A5041573761 @default.
- W2129308384 hasAuthorship W2129308384A5063872240 @default.