FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129310228> ?p ?o ?g. }

• W2129310228 abstract "The most recent guidelines define COPD in a multidimensional way, nevertheless the diagnosis is still linked to the limitation of airflow, usually measured by the reduction in the FEV1/FVC ratio below 70%. However, the severity of obstruction is not directly correlated to symptoms or to invalidity determined by COPD. Thus, besides respiratory function, COPD should be evaluated based on symptoms, frequency and severity of exacerbations, patient’s functional status and health related quality of life (HRQoL). Therapy is mainly aimed at increasing exercise tolerance and reducing dyspnea, with improvement of daily activities and HRQoL. This can be accomplished by a drug-induced reduction of pulmonary hyperinflation and exacerbations frequency and severity. All guidelines recommend bronchodilators as baseline therapy for all stages of COPD, and long-acting inhaled bronchodilators, both beta-2 agonist (LABA) and antimuscarinic (LAMA) drugs, are the most effective in regular treatment in the clinically stable phase. The effectiveness of bronchodilators should be evaluated in terms of functional (relief of bronchial obstruction and pulmonary hyperinflation), symptomatic (exercise tolerance and HRQoL), and clinical improvement (reduction in number or severity of exacerbations), while the absence of a spirometric response is not a reason for interrupting treatment, if there is subjective improvement in symptoms. Because LABA and LAMA act via different mechanisms of action, when administered in combination they can exert additional effects, thus optimizing (i.e. maximizing) sustained bronchodilation in COPD patients with severe airflow limitation, who cannot benefit (or can get only partial benefit) by therapy with a single bronchodilator. Recently, a fixed combination of ultra LABA/LAMA (indacaterol/glycopyrronium) has shown that it is possible to get a stable and persistent bronchodilation, which can help in avoiding undesirable fluctuations of bronchial calibre." @default.
• W2129310228 created "2016-06-24" @default.
• W2129310228 creator A5004445358 @default.
• W2129310228 creator A5030771826 @default.
• W2129310228 creator A5049925872 @default.
• W2129310228 creator A5057990211 @default.
• W2129310228 creator A5071152137 @default.
• W2129310228 creator A5073839386 @default.
• W2129310228 creator A5085665455 @default.
• W2129310228 creator A5087030380 @default.
• W2129310228 creator A5087478030 @default.
• W2129310228 creator A5090449580 @default.
• W2129310228 date "2014-10-15" @default.
• W2129310228 modified "2023-09-23" @default.
• W2129310228 title "COPD: maximization of bronchodilation" @default.
• W2129310228 cites W106863293 @default.
• W2129310228 cites W137920967 @default.
• W2129310228 cites W1487006512 @default.
• W2129310228 cites W1557078354 @default.
• W2129310228 cites W1690343125 @default.
• W2129310228 cites W1966192627 @default.
• W2129310228 cites W1968293253 @default.
• W2129310228 cites W1970629614 @default.
• W2129310228 cites W1975707290 @default.
• W2129310228 cites W1980706893 @default.
• W2129310228 cites W1988077598 @default.
• W2129310228 cites W1989738601 @default.
• W2129310228 cites W1989921611 @default.
• W2129310228 cites W1993592748 @default.
• W2129310228 cites W1999928808 @default.
• W2129310228 cites W2003293665 @default.
• W2129310228 cites W2019464077 @default.
• W2129310228 cites W2022636828 @default.
• W2129310228 cites W2024631328 @default.
• W2129310228 cites W2032171019 @default.
• W2129310228 cites W2040119445 @default.
• W2129310228 cites W2042265551 @default.
• W2129310228 cites W2053024779 @default.
• W2129310228 cites W2053463673 @default.
• W2129310228 cites W2057335633 @default.
• W2129310228 cites W2057359869 @default.
• W2129310228 cites W2057946435 @default.
• W2129310228 cites W2066616351 @default.
• W2129310228 cites W2068877553 @default.
• W2129310228 cites W2071058793 @default.
• W2129310228 cites W2082854368 @default.
• W2129310228 cites W2086342579 @default.
• W2129310228 cites W2088022718 @default.
• W2129310228 cites W2088240660 @default.
• W2129310228 cites W2089834473 @default.
• W2129310228 cites W2094107830 @default.
• W2129310228 cites W2096467996 @default.
• W2129310228 cites W2096723137 @default.
• W2129310228 cites W2102435137 @default.
• W2129310228 cites W2102443712 @default.
• W2129310228 cites W2102590607 @default.
• W2129310228 cites W2104636056 @default.
• W2129310228 cites W2109165189 @default.
• W2129310228 cites W2110783271 @default.
• W2129310228 cites W2112628693 @default.
• W2129310228 cites W2112904335 @default.
• W2129310228 cites W2116505643 @default.
• W2129310228 cites W2116697960 @default.
• W2129310228 cites W2121914298 @default.
• W2129310228 cites W2123850585 @default.
• W2129310228 cites W2125779455 @default.
• W2129310228 cites W2127951128 @default.
• W2129310228 cites W2130703359 @default.
• W2129310228 cites W2133080325 @default.
• W2129310228 cites W2134091333 @default.
• W2129310228 cites W2136581092 @default.
• W2129310228 cites W2136872827 @default.
• W2129310228 cites W2139347600 @default.
• W2129310228 cites W2141034778 @default.
• W2129310228 cites W2142449488 @default.
• W2129310228 cites W2142724633 @default.
• W2129310228 cites W2143615989 @default.
• W2129310228 cites W2145330091 @default.
• W2129310228 cites W2152912650 @default.
• W2129310228 cites W2153372560 @default.
• W2129310228 cites W2156248782 @default.
• W2129310228 cites W2160421825 @default.
• W2129310228 cites W2160609432 @default.
• W2129310228 cites W2165446260 @default.
• W2129310228 cites W2165845432 @default.
• W2129310228 cites W2165909321 @default.
• W2129310228 cites W2171974515 @default.
• W2129310228 cites W2171974699 @default.
• W2129310228 cites W2254789682 @default.
• W2129310228 cites W4211263216 @default.
• W2129310228 doi "https://doi.org/10.1186/2049-6958-9-50" @default.
• W2129310228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4216364" @default.
• W2129310228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25364503" @default.
• W2129310228 hasPublicationYear "2014" @default.
• W2129310228 type Work @default.
• W2129310228 sameAs 2129310228 @default.
• W2129310228 citedByCount "18" @default.
• W2129310228 countsByYear W21293102282014 @default.
• W2129310228 countsByYear W21293102282015 @default.
• W2129310228 countsByYear W21293102282016 @default.

• next