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- W2129311065 abstract "The identification of biological markers of mild Alzheimer's disease (AD) can be extremely useful to improve diagnostic accuracy and/or to monitor the efficacy of putative therapies. In this regard, peripheral cells may be of great importance because of their easy accessibility. Previous studies suggest conformationally altered p53 may be overexpressed in mononuclear cells from AD patients. We measured the mononuclear cells expresion of a conformationally altered p53 in 50 patients with mild Alzheimer's disease, 50 patients with mild cognitive impairment and age-matched 60 controls. Two independent methods to evaluate the differential expression of a conformational mutant p53 were developed. Mononuclear cells were analyzed by immunoprecipitation or by flow cytometric analysis, following incubation with a conformation-specific p53 antibody, which discriminates unfolded p53 tertiary structure. Patients with mild cognitive impairment were followed for 1 year. Mononuclear cells from mild AD patients express a statistically significantly higher amount of mutant-like p53 compared to mononuclear cells from controls. Mononuclear cells from MCI patients who converted to AD also tended to express a higher (not statistically significant) amount of mutant-like p53 compared to patients with MCI who did not convert. This study support the possibility of using the conformational mutant p53 as a new putative marker in the early diagnosis of Alzheimer's disease." @default.
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- W2129311065 date "2010-07-01" @default.
- W2129311065 modified "2023-09-27" @default.
- W2129311065 title "P3-192: Conformationally altered p53 as a peripheral marker for mild Alzheimer's disease" @default.
- W2129311065 doi "https://doi.org/10.1016/j.jalz.2010.05.1690" @default.
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