Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129334819> ?p ?o ?g. }
- W2129334819 endingPage "8119" @default.
- W2129334819 startingPage "8114" @default.
- W2129334819 abstract "Activation-induced deaminase (AID) uses base deamination for class-switch recombination and somatic hypermutation and is related to the mammalian RNA-editing enzyme apolipoprotein B editing catalytic subunit 1 (APOBEC-1). CDD1 is a yeast ortholog of APOBEC-1 that exhibits cytidine deaminase and RNA-editing activity. Here, we present the crystal structure of CDD1 at 2.0-A resolution and its use in comparative modeling of APOBEC-1 and AID. The models explain dimerization and the need for trans-acting loops that contribute to active site formation. Substrate selectivity appears to be regulated by a central active site flap whose size and flexibility accommodate large substrates in contrast to deaminases of pyrimidine metabolism that bind only small nucleosides or free bases. Most importantly, the results suggested both AID and APOBEC-1 are equally likely to bind single-stranded DNA or RNA, which has implications for the identification of natural AID targets." @default.
- W2129334819 created "2016-06-24" @default.
- W2129334819 creator A5023479260 @default.
- W2129334819 creator A5024883911 @default.
- W2129334819 creator A5046436455 @default.
- W2129334819 creator A5049078329 @default.
- W2129334819 creator A5056825976 @default.
- W2129334819 creator A5072996559 @default.
- W2129334819 date "2004-05-17" @default.
- W2129334819 modified "2023-09-25" @default.
- W2129334819 title "The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1" @default.
- W2129334819 cites W1500927181 @default.
- W2129334819 cites W1508885706 @default.
- W2129334819 cites W1539796472 @default.
- W2129334819 cites W1966075431 @default.
- W2129334819 cites W1966501160 @default.
- W2129334819 cites W1970257155 @default.
- W2129334819 cites W1980898330 @default.
- W2129334819 cites W1986265010 @default.
- W2129334819 cites W1986851354 @default.
- W2129334819 cites W1995017064 @default.
- W2129334819 cites W1996805644 @default.
- W2129334819 cites W1999207703 @default.
- W2129334819 cites W2001375348 @default.
- W2129334819 cites W2002043709 @default.
- W2129334819 cites W2008489452 @default.
- W2129334819 cites W2011700223 @default.
- W2129334819 cites W2013083986 @default.
- W2129334819 cites W2020506600 @default.
- W2129334819 cites W2036806870 @default.
- W2129334819 cites W2038560210 @default.
- W2129334819 cites W2042471904 @default.
- W2129334819 cites W2045816796 @default.
- W2129334819 cites W2047852652 @default.
- W2129334819 cites W2048341226 @default.
- W2129334819 cites W2049824360 @default.
- W2129334819 cites W2049930242 @default.
- W2129334819 cites W2060983388 @default.
- W2129334819 cites W2062738638 @default.
- W2129334819 cites W2073563981 @default.
- W2129334819 cites W2073622904 @default.
- W2129334819 cites W2073655863 @default.
- W2129334819 cites W2080180950 @default.
- W2129334819 cites W2085366207 @default.
- W2129334819 cites W2087405909 @default.
- W2129334819 cites W2090853404 @default.
- W2129334819 cites W2093049412 @default.
- W2129334819 cites W2094617711 @default.
- W2129334819 cites W2096651897 @default.
- W2129334819 cites W2100984579 @default.
- W2129334819 cites W2101220662 @default.
- W2129334819 cites W2105273370 @default.
- W2129334819 cites W2107408311 @default.
- W2129334819 cites W2114520383 @default.
- W2129334819 cites W2116280853 @default.
- W2129334819 cites W2119314909 @default.
- W2129334819 cites W2119460195 @default.
- W2129334819 cites W2128082858 @default.
- W2129334819 cites W2139387072 @default.
- W2129334819 cites W2140097965 @default.
- W2129334819 cites W2150010396 @default.
- W2129334819 cites W2165608602 @default.
- W2129334819 cites W2167280114 @default.
- W2129334819 cites W2167489991 @default.
- W2129334819 cites W2034937673 @default.
- W2129334819 doi "https://doi.org/10.1073/pnas.0400493101" @default.
- W2129334819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/419566" @default.
- W2129334819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15148397" @default.
- W2129334819 hasPublicationYear "2004" @default.
- W2129334819 type Work @default.
- W2129334819 sameAs 2129334819 @default.
- W2129334819 citedByCount "81" @default.
- W2129334819 countsByYear W21293348192012 @default.
- W2129334819 countsByYear W21293348192013 @default.
- W2129334819 countsByYear W21293348192014 @default.
- W2129334819 countsByYear W21293348192015 @default.
- W2129334819 countsByYear W21293348192016 @default.
- W2129334819 countsByYear W21293348192017 @default.
- W2129334819 countsByYear W21293348192018 @default.
- W2129334819 countsByYear W21293348192019 @default.
- W2129334819 countsByYear W21293348192020 @default.
- W2129334819 countsByYear W21293348192022 @default.
- W2129334819 countsByYear W21293348192023 @default.
- W2129334819 crossrefType "journal-article" @default.
- W2129334819 hasAuthorship W2129334819A5023479260 @default.
- W2129334819 hasAuthorship W2129334819A5024883911 @default.
- W2129334819 hasAuthorship W2129334819A5046436455 @default.
- W2129334819 hasAuthorship W2129334819A5049078329 @default.
- W2129334819 hasAuthorship W2129334819A5056825976 @default.
- W2129334819 hasAuthorship W2129334819A5072996559 @default.
- W2129334819 hasBestOaLocation W21293348192 @default.
- W2129334819 hasConcept C104317684 @default.
- W2129334819 hasConcept C128526571 @default.
- W2129334819 hasConcept C141231307 @default.
- W2129334819 hasConcept C145782189 @default.
- W2129334819 hasConcept C159654299 @default.
- W2129334819 hasConcept C181199279 @default.
- W2129334819 hasConcept C21786251 @default.