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- W2129336712 abstract "Urokinase, a serine protease, catalyzes the conversion of plasminogen to plasmin, which is responsible for dissolution of clots in blood vessels. It is an important drug for treatment of thromboembolic disease. Production of urokinase by mammalian cell culture has the following important steps: synthesis, regulation and secretion. Production and accumulation of this product in a bioreactor is a real challenge for biochemical engineers. Considerable information at molecular level needs to be understood for production of urokinase in order to correlate different parameters, which in turn can maximize the productivity. This information will be highlighted in this review. Moreover, urokinase production is a product-inhibited process. Therefore, in situ urokinase separation strategy is required to operate a bioreactor at its maximum urokinase formation rate. Integrated urokinase production and isolation processes developed recently will also be discussed briefly in this review." @default.
- W2129336712 created "2016-06-24" @default.
- W2129336712 creator A5011082571 @default.
- W2129336712 creator A5040830379 @default.
- W2129336712 creator A5041402257 @default.
- W2129336712 creator A5048463821 @default.
- W2129336712 date "2006-09-01" @default.
- W2129336712 modified "2023-10-16" @default.
- W2129336712 title "Synthesis, regulation and production of urokinase using mammalian cell culture: A comprehensive review" @default.
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- W2129336712 doi "https://doi.org/10.1016/j.biotechadv.2006.05.002" @default.
- W2129336712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16822639" @default.
- W2129336712 hasPublicationYear "2006" @default.