FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129341768> ?p ?o ?g. }

• W2129341768 endingPage "1732" @default.
• W2129341768 startingPage "1732" @default.
• W2129341768 abstract "New interventions against infectious diseases require a detailed knowledge and understanding of pathogen–host interactions and pathogeneses at the molecular level. The combination of the considerable advances in systems biology research with methods to explore the structural biology of molecules is poised to provide new insights into these areas. Importantly, exploring three-dimensional structures of proteins is central to understanding disease processes, and establishing structure–function relationships assists in identification and assessment of new drug and vaccine targets. Frequently, the molecular arsenal deployed by invading pathogens, and in particular parasites, reveals a common theme whereby families of proteins with conserved three-dimensional folds play crucial roles in infectious processes, but individual members of such families show high levels of specialisation, which is often achieved through grafting particular structural features onto the shared overall fold. Accordingly, the applicability of predictive methodologies based on the primary structure of proteins or genome annotations is limited, particularly when thorough knowledge of molecular-level mechanisms is required. Such instances exemplify the need for experimental three-dimensional structures provided by protein crystallography, which remain an essential component of this area of research. In the present article, we review two examples of key protein families recently investigated in our laboratories, which could represent intervention targets in the metabolome or secretome of parasites." @default.
• W2129341768 created "2016-06-24" @default.
• W2129341768 creator A5001917619 @default.
• W2129341768 creator A5019687799 @default.
• W2129341768 creator A5025007734 @default.
• W2129341768 creator A5035324209 @default.
• W2129341768 creator A5039640617 @default.
• W2129341768 creator A5069735692 @default.
• W2129341768 creator A5076495310 @default.
• W2129341768 creator A5085039675 @default.
• W2129341768 date "2014-01-01" @default.
• W2129341768 modified "2023-09-25" @default.
• W2129341768 title "The Relevance of Structural Biology in Studying Molecules Involved in Parasite–Host Interactions: Potential for Designing New Interventions" @default.
• W2129341768 cites W1508385406 @default.
• W2129341768 cites W1559440166 @default.
• W2129341768 cites W1576773659 @default.
• W2129341768 cites W1586815054 @default.
• W2129341768 cites W1598106324 @default.
• W2129341768 cites W1600207471 @default.
• W2129341768 cites W1906013054 @default.
• W2129341768 cites W1953699855 @default.
• W2129341768 cites W1968368079 @default.
• W2129341768 cites W1972104257 @default.
• W2129341768 cites W1973814270 @default.
• W2129341768 cites W1979471566 @default.
• W2129341768 cites W1981225466 @default.
• W2129341768 cites W1984977154 @default.
• W2129341768 cites W1987989908 @default.
• W2129341768 cites W1990128542 @default.
• W2129341768 cites W1995141525 @default.
• W2129341768 cites W1996035428 @default.
• W2129341768 cites W1996592025 @default.
• W2129341768 cites W2003897861 @default.
• W2129341768 cites W2008020912 @default.
• W2129341768 cites W2008437579 @default.
• W2129341768 cites W2009117327 @default.
• W2129341768 cites W2011790148 @default.
• W2129341768 cites W2017952818 @default.
• W2129341768 cites W2018349038 @default.
• W2129341768 cites W2019552956 @default.
• W2129341768 cites W2023495454 @default.
• W2129341768 cites W2025767497 @default.
• W2129341768 cites W2025789813 @default.
• W2129341768 cites W2026075013 @default.
• W2129341768 cites W2026589915 @default.
• W2129341768 cites W2030707187 @default.
• W2129341768 cites W2031130016 @default.
• W2129341768 cites W2031612045 @default.
• W2129341768 cites W2031945277 @default.
• W2129341768 cites W2033417036 @default.
• W2129341768 cites W2035967126 @default.
• W2129341768 cites W2041031948 @default.
• W2129341768 cites W2041844634 @default.
• W2129341768 cites W2043129641 @default.
• W2129341768 cites W2048527318 @default.
• W2129341768 cites W2048846997 @default.
• W2129341768 cites W2049540904 @default.
• W2129341768 cites W2052932001 @default.
• W2129341768 cites W2054080213 @default.
• W2129341768 cites W2064493097 @default.
• W2129341768 cites W2064874874 @default.
• W2129341768 cites W2069724690 @default.
• W2129341768 cites W2072727937 @default.
• W2129341768 cites W2075524784 @default.
• W2129341768 cites W2076455675 @default.
• W2129341768 cites W2085075048 @default.
• W2129341768 cites W2085428387 @default.
• W2129341768 cites W2089440412 @default.
• W2129341768 cites W2090565001 @default.
• W2129341768 cites W2090721573 @default.
• W2129341768 cites W2091201141 @default.
• W2129341768 cites W2091414864 @default.
• W2129341768 cites W2092796622 @default.
• W2129341768 cites W2095603402 @default.
• W2129341768 cites W2095635649 @default.
• W2129341768 cites W2099365510 @default.
• W2129341768 cites W2103517636 @default.
• W2129341768 cites W2106196463 @default.
• W2129341768 cites W2110779750 @default.
• W2129341768 cites W2112393852 @default.
• W2129341768 cites W2115673680 @default.
• W2129341768 cites W2121339927 @default.
• W2129341768 cites W2121764927 @default.
• W2129341768 cites W2125575889 @default.
• W2129341768 cites W2134639738 @default.
• W2129341768 cites W2135284380 @default.
• W2129341768 cites W2138166435 @default.
• W2129341768 cites W2142336276 @default.
• W2129341768 cites W2147710952 @default.
• W2129341768 cites W2147836597 @default.
• W2129341768 cites W2151764880 @default.
• W2129341768 cites W2156188380 @default.
• W2129341768 cites W2157157836 @default.
• W2129341768 cites W2163635263 @default.
• W2129341768 cites W2163994561 @default.
• W2129341768 cites W2168380071 @default.
• W2129341768 cites W2327166516 @default.
• W2129341768 cites W4247408894 @default.

• next