FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129341775> ?p ?o ?g. }

• W2129341775 endingPage "1885" @default.
• W2129341775 startingPage "1876" @default.
• W2129341775 abstract "We found earlier that apoA-I variants that induced hypertriglyceridemia (HTG) in mice had increased affinity to TG-rich lipoproteins and thereby impaired their catabolism. Here, we tested whether a naturally occurring human apoA-I mutation, Lys107del, associated with HTG also promotes apoA-I binding to TG-rich particles. We expressed apoA-I[Lys107del] variant in Escherichia coli, studied its binding to TG-rich emulsion particles, and performed a physicochemical characterization of the protein. Compared with WT apoA-I, apoA-I[Lys107del] showed enhanced binding to TG-rich particles, lower stability, and greater exposure of hydrophobic surfaces. The crystal structure of truncated, Δ(185-243), apoA-I suggests that deletion of Lys107 disrupts helix registration and disturbs a stabilizing salt bridge network in the N-terminal helical bundle. To elucidate the structural changes responsible for the altered function of apoA-I[Lys107del], we studied another mutant, apoA-I [Lys107Ala]. Our findings suggest that the registry shift and ensuing disruption of the inter-helical salt bridges in apoA-I[Lys107del] result in destabilization of the helical bundle structure and greater exposure of hydrophobic surfaces. We conclude that the structural changes in the apoA-I[Lys107del] variant facilitate its binding to TG-rich lipoproteins and thus, may reduce their lipolysis and contribute to the development of HTG in carriers of the mutation." @default.
• W2129341775 created "2016-06-24" @default.
• W2129341775 creator A5024374500 @default.
• W2129341775 creator A5034695786 @default.
• W2129341775 creator A5085977786 @default.
• W2129341775 date "2014-09-01" @default.
• W2129341775 modified "2023-10-15" @default.
• W2129341775 title "Binding of human apoA-I[K107del] variant to TG-rich particles: implications for mechanisms underlying hypertriglyceridemia" @default.
• W2129341775 cites W1513897103 @default.
• W2129341775 cites W1573915513 @default.
• W2129341775 cites W1580211147 @default.
• W2129341775 cites W1775749144 @default.
• W2129341775 cites W1971060785 @default.
• W2129341775 cites W1971796665 @default.
• W2129341775 cites W1972479546 @default.
• W2129341775 cites W1973646070 @default.
• W2129341775 cites W1977597405 @default.
• W2129341775 cites W1980506200 @default.
• W2129341775 cites W1994837493 @default.
• W2129341775 cites W1997720054 @default.
• W2129341775 cites W2002545455 @default.
• W2129341775 cites W2004137387 @default.
• W2129341775 cites W2006324786 @default.
• W2129341775 cites W2007771300 @default.
• W2129341775 cites W2011933541 @default.
• W2129341775 cites W2013008998 @default.
• W2129341775 cites W2024271923 @default.
• W2129341775 cites W2033019705 @default.
• W2129341775 cites W2036747551 @default.
• W2129341775 cites W2037379679 @default.
• W2129341775 cites W2041759991 @default.
• W2129341775 cites W2045474288 @default.
• W2129341775 cites W2051560414 @default.
• W2129341775 cites W2052188391 @default.
• W2129341775 cites W2052288531 @default.
• W2129341775 cites W2055194273 @default.
• W2129341775 cites W2062228103 @default.
• W2129341775 cites W2062740856 @default.
• W2129341775 cites W2063174765 @default.
• W2129341775 cites W2066894739 @default.
• W2129341775 cites W2068685982 @default.
• W2129341775 cites W2070162893 @default.
• W2129341775 cites W2077406753 @default.
• W2129341775 cites W2078155605 @default.
• W2129341775 cites W2080036080 @default.
• W2129341775 cites W2080826271 @default.
• W2129341775 cites W2080848089 @default.
• W2129341775 cites W2084500770 @default.
• W2129341775 cites W2093272247 @default.
• W2129341775 cites W2102978920 @default.
• W2129341775 cites W2117622708 @default.
• W2129341775 cites W2135569210 @default.
• W2129341775 cites W2145538573 @default.
• W2129341775 cites W2148357813 @default.
• W2129341775 cites W2151736987 @default.
• W2129341775 cites W2165906160 @default.
• W2129341775 cites W2169582126 @default.
• W2129341775 cites W2332032243 @default.
• W2129341775 cites W2334667221 @default.
• W2129341775 cites W4232879552 @default.
• W2129341775 doi "https://doi.org/10.1194/jlr.m047241" @default.
• W2129341775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4617355" @default.
• W2129341775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24919401" @default.
• W2129341775 hasPublicationYear "2014" @default.
• W2129341775 type Work @default.
• W2129341775 sameAs 2129341775 @default.
• W2129341775 citedByCount "8" @default.
• W2129341775 countsByYear W21293417752015 @default.
• W2129341775 countsByYear W21293417752016 @default.
• W2129341775 countsByYear W21293417752017 @default.
• W2129341775 countsByYear W21293417752018 @default.
• W2129341775 countsByYear W21293417752020 @default.
• W2129341775 countsByYear W21293417752021 @default.
• W2129341775 countsByYear W21293417752023 @default.
• W2129341775 crossrefType "journal-article" @default.
• W2129341775 hasAuthorship W2129341775A5024374500 @default.
• W2129341775 hasAuthorship W2129341775A5034695786 @default.
• W2129341775 hasAuthorship W2129341775A5085977786 @default.
• W2129341775 hasBestOaLocation W21293417751 @default.
• W2129341775 hasConcept C104317684 @default.
• W2129341775 hasConcept C107824862 @default.
• W2129341775 hasConcept C12554922 @default.
• W2129341775 hasConcept C140985366 @default.
• W2129341775 hasConcept C143065580 @default.
• W2129341775 hasConcept C171089720 @default.
• W2129341775 hasConcept C185592680 @default.
• W2129341775 hasConcept C203087120 @default.
• W2129341775 hasConcept C2776919658 @default.
• W2129341775 hasConcept C2778163477 @default.
• W2129341775 hasConcept C2778913445 @default.
• W2129341775 hasConcept C30765947 @default.
• W2129341775 hasConcept C47701112 @default.
• W2129341775 hasConcept C51639874 @default.
• W2129341775 hasConcept C55493867 @default.
• W2129341775 hasConcept C62231903 @default.
• W2129341775 hasConcept C86803240 @default.
• W2129341775 hasConcept C96942376 @default.
• W2129341775 hasConceptScore W2129341775C104317684 @default.

• next