FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129343911> ?p ?o ?g. }

• W2129343911 endingPage "482" @default.
• W2129343911 startingPage "471" @default.
• W2129343911 abstract "Insect pests are responsible for human suffering and financial losses worldwide. New and environmentally safe insecticides are urgently needed to cope with these serious problems. Resistance to current insecticides has resulted in a resurgence of insect pests, and growing concerns about insecticide toxicity to humans discourage the use of insecticides for pest control. The small market for insecticides has hampered insecticide development; however, advances in genomics and structural genomics offer new opportunities to develop insecticides that are less dependent on the insecticide market. This review summarizes the literature data that support the hypothesis that an insect-specific cysteine residue located at the opening of the acetylcholinesterase active site is a promising target site for developing new insecticides with reduced off-target toxicity and low propensity for insect resistance. These data are used to discuss the differences between targeting the insect-specific cysteine residue and targeting the ubiquitous catalytic serine residue of acetylcholinesterase from the perspective of reducing off-target toxicity and insect resistance. Also discussed is the prospect of developing cysteine-targeting anticholinesterases as effective and environmentally safe insecticides for control of disease vectors, crop damage, and residential insect pests within the financial confines of the present insecticide market. Keywords: Pest control, disease vector control, anti-malaria, crop damage control, irreversible inhibitors, anticholinesterase, cysteine residue, homology, insecticide, serine" @default.
• W2129343911 created "2016-06-24" @default.
• W2129343911 creator A5005439086 @default.
• W2129343911 creator A5045999136 @default.
• W2129343911 creator A5051193062 @default.
• W2129343911 creator A5062493231 @default.
• W2129343911 creator A5075678040 @default.
• W2129343911 date "2012-04-01" @default.
• W2129343911 modified "2023-09-27" @default.
• W2129343911 title "Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides" @default.
• W2129343911 cites W1601189744 @default.
• W2129343911 cites W187691462 @default.
• W2129343911 cites W1929999978 @default.
• W2129343911 cites W1963976032 @default.
• W2129343911 cites W1965417821 @default.
• W2129343911 cites W1972492016 @default.
• W2129343911 cites W1974063204 @default.
• W2129343911 cites W1975406241 @default.
• W2129343911 cites W1978861766 @default.
• W2129343911 cites W1980314143 @default.
• W2129343911 cites W1984600357 @default.
• W2129343911 cites W1989472982 @default.
• W2129343911 cites W1989549231 @default.
• W2129343911 cites W1990883063 @default.
• W2129343911 cites W1994271603 @default.
• W2129343911 cites W1999853694 @default.
• W2129343911 cites W2000414525 @default.
• W2129343911 cites W2003271727 @default.
• W2129343911 cites W2003450901 @default.
• W2129343911 cites W2006665768 @default.
• W2129343911 cites W2006732206 @default.
• W2129343911 cites W2006872098 @default.
• W2129343911 cites W2008259367 @default.
• W2129343911 cites W2008989713 @default.
• W2129343911 cites W2009200062 @default.
• W2129343911 cites W2011559245 @default.
• W2129343911 cites W2012691421 @default.
• W2129343911 cites W2013322015 @default.
• W2129343911 cites W2015331417 @default.
• W2129343911 cites W2016219772 @default.
• W2129343911 cites W2029017950 @default.
• W2129343911 cites W2030174117 @default.
• W2129343911 cites W2032220929 @default.
• W2129343911 cites W2032887307 @default.
• W2129343911 cites W2035123918 @default.
• W2129343911 cites W2038360744 @default.
• W2129343911 cites W2040602126 @default.
• W2129343911 cites W2043060277 @default.
• W2129343911 cites W2045542952 @default.
• W2129343911 cites W2045568447 @default.
• W2129343911 cites W2050485087 @default.
• W2129343911 cites W2050684426 @default.
• W2129343911 cites W2051679721 @default.
• W2129343911 cites W2052651409 @default.
• W2129343911 cites W2055018461 @default.
• W2129343911 cites W2066691785 @default.
• W2129343911 cites W2069696483 @default.
• W2129343911 cites W2069707041 @default.
• W2129343911 cites W2070638075 @default.
• W2129343911 cites W2085958374 @default.
• W2129343911 cites W2086171239 @default.
• W2129343911 cites W2086799620 @default.
• W2129343911 cites W2092848086 @default.
• W2129343911 cites W2096836461 @default.
• W2129343911 cites W2097233732 @default.
• W2129343911 cites W2098864336 @default.
• W2129343911 cites W2104457427 @default.
• W2129343911 cites W2109490221 @default.
• W2129343911 cites W2124100477 @default.
• W2129343911 cites W2124606019 @default.
• W2129343911 cites W2127341325 @default.
• W2129343911 cites W2127992714 @default.
• W2129343911 cites W2128931040 @default.
• W2129343911 cites W2131539808 @default.
• W2129343911 cites W2141652419 @default.
• W2129343911 cites W2143410390 @default.
• W2129343911 cites W2144721986 @default.
• W2129343911 cites W2150996942 @default.
• W2129343911 cites W2165005941 @default.
• W2129343911 cites W2171158206 @default.
• W2129343911 cites W2172143171 @default.
• W2129343911 cites W2179044652 @default.
• W2129343911 cites W960083271 @default.
• W2129343911 doi "https://doi.org/10.2174/138945012799499703" @default.
• W2129343911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3343382" @default.
• W2129343911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22280344" @default.
• W2129343911 hasPublicationYear "2012" @default.
• W2129343911 type Work @default.
• W2129343911 sameAs 2129343911 @default.
• W2129343911 citedByCount "49" @default.
• W2129343911 countsByYear W21293439112012 @default.
• W2129343911 countsByYear W21293439112013 @default.
• W2129343911 countsByYear W21293439112014 @default.
• W2129343911 countsByYear W21293439112015 @default.
• W2129343911 countsByYear W21293439112016 @default.
• W2129343911 countsByYear W21293439112017 @default.
• W2129343911 countsByYear W21293439112018 @default.
• W2129343911 countsByYear W21293439112019 @default.

• next