FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129348909> ?p ?o ?g. }

• W2129348909 endingPage "125" @default.
• W2129348909 startingPage "112" @default.
• W2129348909 abstract "Treatment of acute renal failure (ARF) would be enhanced by identification of factors that accelerate renal recovery from injury. Parathyroid hormone-related protein (PTHrP) and hepatocyte growth factor (HGF) have been shown to stimulate proliferation in proximal nephron-derived cells. For studying the pathophysiologic roles and therapeutic potential of these two factors in ARF, transgenic mice overexpressing PTHrP or HGF in the proximal tubule under the direction of the gamma-glutamyl transpeptidase-I promoter were developed. These mice display (1) abundant expression of the respective transgenes in the kidney; (2) similar PTH type I receptor and HGF receptor (c-met) expression levels in the proximal tubule compared with control littermates; and (3) normal renal morphology, function, and tubule cell proliferation under basal conditions. However, in contrast to control mice, when acute ischemic renal injury was induced, renal function rapidly and dramatically recovered in HGF-overexpressing mice. In addition, 48 h after ischemia, HGF-overexpressing transgenic mice displayed a fourfold increase in tubule cell proliferation and a threefold decrease in apoptotic tubule cell death compared with control mice. In contrast, PTHrP-overexpressing mice responded to either ischemic or folic acid-induced renal damage similarly to control mice. These studies demonstrate that overexpression of PTHrP in the proximal nephron of mice does not seem to provide protection against acute renal injury. In marked contrast, HGF overexpression results in dramatic protection from ischemia-induced ARF, without inducing any apparent alteration in the physiology of the kidney under normal conditions. These studies suggest that HGF, when targeted specifically to the proximal tubule, may have therapeutic potential in providing protection against ischemia-induced renal failure." @default.
• W2129348909 created "2016-06-24" @default.
• W2129348909 creator A5006140692 @default.
• W2129348909 creator A5015655911 @default.
• W2129348909 creator A5027526622 @default.
• W2129348909 creator A5063643118 @default.
• W2129348909 creator A5065491541 @default.
• W2129348909 creator A5065683911 @default.
• W2129348909 creator A5074426697 @default.
• W2129348909 creator A5075901112 @default.
• W2129348909 creator A5086184261 @default.
• W2129348909 date "2004-01-01" @default.
• W2129348909 modified "2023-10-18" @default.
• W2129348909 title "Prevention of Acute Ischemic Renal Failure by Targeted Delivery of Growth Factors to the Proximal Tubule in Transgenic Mice" @default.
• W2129348909 cites W120572407 @default.
• W2129348909 cites W12774429 @default.
• W2129348909 cites W1595670287 @default.
• W2129348909 cites W1909244525 @default.
• W2129348909 cites W1922925354 @default.
• W2129348909 cites W1968235132 @default.
• W2129348909 cites W1970120554 @default.
• W2129348909 cites W1972781462 @default.
• W2129348909 cites W1988658462 @default.
• W2129348909 cites W1992251016 @default.
• W2129348909 cites W1993931106 @default.
• W2129348909 cites W1994074583 @default.
• W2129348909 cites W1996446862 @default.
• W2129348909 cites W1999806767 @default.
• W2129348909 cites W2002639486 @default.
• W2129348909 cites W2005487014 @default.
• W2129348909 cites W2009900140 @default.
• W2129348909 cites W2012074873 @default.
• W2129348909 cites W2015001618 @default.
• W2129348909 cites W2020882360 @default.
• W2129348909 cites W2036755333 @default.
• W2129348909 cites W2038625466 @default.
• W2129348909 cites W2040851157 @default.
• W2129348909 cites W2042343936 @default.
• W2129348909 cites W2042887426 @default.
• W2129348909 cites W2043155095 @default.
• W2129348909 cites W2050665615 @default.
• W2129348909 cites W2051047536 @default.
• W2129348909 cites W2052534316 @default.
• W2129348909 cites W2055880820 @default.
• W2129348909 cites W2057993832 @default.
• W2129348909 cites W2067611598 @default.
• W2129348909 cites W2090429649 @default.
• W2129348909 cites W2091733148 @default.
• W2129348909 cites W2092281480 @default.
• W2129348909 cites W2112350251 @default.
• W2129348909 cites W2113479676 @default.
• W2129348909 cites W2125143018 @default.
• W2129348909 cites W2131761461 @default.
• W2129348909 cites W2147078969 @default.
• W2129348909 cites W2162923280 @default.
• W2129348909 cites W2279819281 @default.
• W2129348909 cites W273579356 @default.
• W2129348909 cites W56209817 @default.
• W2129348909 cites W63784371 @default.
• W2129348909 doi "https://doi.org/10.1097/01.asn.0000102470.12285.c6" @default.
• W2129348909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14694163" @default.
• W2129348909 hasPublicationYear "2004" @default.
• W2129348909 type Work @default.
• W2129348909 sameAs 2129348909 @default.
• W2129348909 citedByCount "56" @default.
• W2129348909 countsByYear W21293489092012 @default.
• W2129348909 countsByYear W21293489092013 @default.
• W2129348909 countsByYear W21293489092014 @default.
• W2129348909 countsByYear W21293489092015 @default.
• W2129348909 countsByYear W21293489092016 @default.
• W2129348909 countsByYear W21293489092017 @default.
• W2129348909 countsByYear W21293489092018 @default.
• W2129348909 countsByYear W21293489092019 @default.
• W2129348909 countsByYear W21293489092020 @default.
• W2129348909 countsByYear W21293489092021 @default.
• W2129348909 countsByYear W21293489092022 @default.
• W2129348909 countsByYear W21293489092023 @default.
• W2129348909 crossrefType "journal-article" @default.
• W2129348909 hasAuthorship W2129348909A5006140692 @default.
• W2129348909 hasAuthorship W2129348909A5015655911 @default.
• W2129348909 hasAuthorship W2129348909A5027526622 @default.
• W2129348909 hasAuthorship W2129348909A5063643118 @default.
• W2129348909 hasAuthorship W2129348909A5065491541 @default.
• W2129348909 hasAuthorship W2129348909A5065683911 @default.
• W2129348909 hasAuthorship W2129348909A5074426697 @default.
• W2129348909 hasAuthorship W2129348909A5075901112 @default.
• W2129348909 hasAuthorship W2129348909A5086184261 @default.
• W2129348909 hasBestOaLocation W21293489091 @default.
• W2129348909 hasConcept C102230213 @default.
• W2129348909 hasConcept C104317684 @default.
• W2129348909 hasConcept C126322002 @default.
• W2129348909 hasConcept C134018914 @default.
• W2129348909 hasConcept C141035611 @default.
• W2129348909 hasConcept C170493617 @default.
• W2129348909 hasConcept C2776996007 @default.
• W2129348909 hasConcept C2780091579 @default.
• W2129348909 hasConcept C2780114680 @default.
• W2129348909 hasConcept C2780472472 @default.

• next