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• W2129351263 endingPage "1286" @default.
• W2129351263 startingPage "1279" @default.
• W2129351263 abstract "Symmetry is a remarkably constant clinical feature of chronic inflammatory disease. Rheumatoid arthritis is almost by definition symmetrical [1]. Osteoarthritis, psoriasis and some of its associated arthritides are also symmetrical [2–4]. Pulmonary fibrosis, glomerulonephritis and sympathetic ophthalmia are also symmetrical inflammatory conditions. Whilst the pathophysiology behind this symmetry is unexplained, we and others have speculated that it is likely to be mediated via neurological mechanisms crossing through the spinal cord [5, 6]. The two sides of the spinal column have largely been thought to function independently of each other. There are three lines of evidence to suggest that this is not true. Careful anatomical studies of the spinal cord show transmedian fibres decussating posteriorly at all levels of the spinal cord to synapse in the laminae on the contralateral dorsal horn. These neuronal connections have been seen in many different species, including several primates (Fig. 1). Szentagothai [7], using Golgi analysis on young cats and dogs, showed that neurons with their cell bodies in the substantia gelatinosa send contralateral axons that appear to synapse in the contralateral substantia gelatinosa. Perl and Light [8] corroborated these findings after they had applied horseradish peroxidase to rat, cat and monkey dorsal rootlets. They found projections into the contralateral substantia gelatinosa as well as the ventral portion of the nucleus propius. Culberson et al. [9], using cresyl violet acetate (Fink-Heimer method), identified crossed afferent projections throughout the spinal cord, originating and terminating in laminae III–IV, in four mammalian species. These anatomical studies provide evidence that the opportunity exists for crosstalk between the left and the right sides of the spinal column. Functional studies of decerebrate rats demonstrate that such cross-communication can produce contralateral responses. Electrical stimulation of contralateral peripheral nerves is known to inhibit flexor reflex pathways in the spinal cord [10] as well as the long latency of C-fibre-evoked activity in dorsal horn cells [11, 12]. Contralateral dorsal horn cells are inhibited in response to noxious stimuli applied to the limb or tails of rats [13, 14]. Further electrophysiological studies confirm the presence of neurons in the dorsal horn that have bilateral receptive fields. Of relevance to this article is that the number of these neurons with bilateral receptive fields increases in the presence of unilateral inflammation [15, 16]. Grubb et al. [17] also showed that some of the fields on the contralateral side can become excitatory rather than inhibitory. At what level are these contralateral responses mediated? Woolf [16] documented the persistent reduction in flexor reflex thresholds contralaterally after noxious thermal stimuli had been applied to decerebrate rats with an intact brainstem. Fitzgerald [18], using a decerebrate, spinalized rat model, showed that a contralateral effect on dorsal horn fibres need not involve such higher pathways. Although direct contralateral spinal pathways exist in experimental conditions, there are likely to be significant supraspinal influences in vivo. This is suggested by several studies detailing an attenuation of central sensitization and secondary hyperalgesia following spinalization or inactivation of the rostral ventral medulla in a review of rat models of acute pain [19]." @default.
• W2129351263 created "2016-06-24" @default.
• W2129351263 creator A5034813197 @default.
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• W2129351263 creator A5089099342 @default.
• W2129351263 date "2003-07-16" @default.
• W2129351263 modified "2023-09-23" @default.
• W2129351263 title "A review of contralateral responses to a unilateral inflammatory lesion" @default.
• W2129351263 cites W1525957592 @default.
• W2129351263 cites W1728621691 @default.
• W2129351263 cites W1742524703 @default.
• W2129351263 cites W1954089873 @default.
• W2129351263 cites W1963810899 @default.
• W2129351263 cites W1965584870 @default.
• W2129351263 cites W1965653351 @default.
• W2129351263 cites W1965765982 @default.
• W2129351263 cites W1968110345 @default.
• W2129351263 cites W1970474009 @default.
• W2129351263 cites W1974198080 @default.
• W2129351263 cites W1977919560 @default.
• W2129351263 cites W1984621697 @default.
• W2129351263 cites W1984929776 @default.
• W2129351263 cites W1988100049 @default.
• W2129351263 cites W1993183621 @default.
• W2129351263 cites W1997475807 @default.
• W2129351263 cites W1999240544 @default.
• W2129351263 cites W2001699192 @default.
• W2129351263 cites W2003176540 @default.
• W2129351263 cites W2007055803 @default.
• W2129351263 cites W2009047487 @default.
• W2129351263 cites W2009766055 @default.
• W2129351263 cites W2010506344 @default.
• W2129351263 cites W2014337228 @default.
• W2129351263 cites W2016542780 @default.
• W2129351263 cites W2017432417 @default.
• W2129351263 cites W2019579728 @default.
• W2129351263 cites W2019674556 @default.
• W2129351263 cites W2021098535 @default.
• W2129351263 cites W2023109035 @default.
• W2129351263 cites W2026733413 @default.
• W2129351263 cites W2028283586 @default.
• W2129351263 cites W2032341534 @default.
• W2129351263 cites W2034109996 @default.
• W2129351263 cites W2041609594 @default.
• W2129351263 cites W2042749300 @default.
• W2129351263 cites W2050833972 @default.
• W2129351263 cites W2051337621 @default.
• W2129351263 cites W2052691165 @default.
• W2129351263 cites W2053277833 @default.
• W2129351263 cites W2054710619 @default.
• W2129351263 cites W2055723831 @default.
• W2129351263 cites W2058212399 @default.
• W2129351263 cites W2061171747 @default.
• W2129351263 cites W2062250586 @default.
• W2129351263 cites W2063772822 @default.
• W2129351263 cites W2065427176 @default.
• W2129351263 cites W2068947209 @default.
• W2129351263 cites W2073912430 @default.
• W2129351263 cites W2073997846 @default.
• W2129351263 cites W2074802335 @default.
• W2129351263 cites W2079607078 @default.
• W2129351263 cites W2080076872 @default.
• W2129351263 cites W2082196022 @default.
• W2129351263 cites W2082994168 @default.
• W2129351263 cites W2085474248 @default.
• W2129351263 cites W2087207492 @default.
• W2129351263 cites W2089406505 @default.
• W2129351263 cites W2089568401 @default.
• W2129351263 cites W2090798853 @default.
• W2129351263 cites W2095051237 @default.
• W2129351263 cites W2098015409 @default.
• W2129351263 cites W2098885783 @default.
• W2129351263 cites W2105537472 @default.
• W2129351263 cites W2109928358 @default.
• W2129351263 cites W2118284287 @default.
• W2129351263 cites W2126348550 @default.
• W2129351263 cites W2132829674 @default.
• W2129351263 cites W2134218817 @default.
• W2129351263 cites W2146890480 @default.
• W2129351263 cites W2150758198 @default.
• W2129351263 cites W2152348310 @default.
• W2129351263 cites W2156027902 @default.
• W2129351263 cites W2164962202 @default.
• W2129351263 cites W2167563378 @default.
• W2129351263 cites W2191530456 @default.
• W2129351263 cites W2193066123 @default.
• W2129351263 cites W2237362523 @default.
• W2129351263 cites W2334267628 @default.
• W2129351263 cites W2402206721 @default.
• W2129351263 cites W2406090639 @default.
• W2129351263 cites W2411866033 @default.
• W2129351263 cites W592023942 @default.
• W2129351263 cites W69095325 @default.
• W2129351263 cites W46650105 @default.
• W2129351263 doi "https://doi.org/10.1093/rheumatology/keg397" @default.

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