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• W2129351690 abstract "Obesity and overweight has quickly become a global epidemic, contributing to the increase of cardiovascular problems, diabetes and hypertension, and even resulting in death. In the market, there are drugs that help weight loss like amphetamines. In recent years, sibutramine has been used as an appetite suppressant and metabolism stimulant, especially in the first trimester of pregnancy by women who didn't know that they were pregnant. This work aim to evaluate visceral anomaly frequency in the progeny of overweight and non-overweight female rats treated with sibutramine. Forty Wistar female rats were used and classified into two groups: non-overweight (20 rats) and overweight (20 rats). Overweight was stimulated through the intake of hypercaloric diet. In the adult phase, the female rats were treated with sibutramin for 15 days and then mated to normal rats; the treatment continued until the fifteenth day of pregnancy. Untreated groups received only saline dose (0.9% NaCl) and treated groups received sibutramine dose (6 mg/kg). When treatment with sibutramin started, four groups were formed: non-overweight untreated group (control - 9 rats), non-overweight group treated with sibutramin (5 rats), overweight untreated group (6 rats), overweight group treated with sibutramin (7 rats). In the afternoon of the twentieth day of pregnancy, the rats were anesthetized and sacrificed to realize the laparotomy. The fetuses were removed and fixed in Bodian solution for visceral anomaly analysis. This study showed that the overweight group treated with sibutramine presented a significantly higher amount of fetuses with anomalies (28 fetuses) like dilated trachea, dilated ureter, dilated nasal septum, dilated renal calyx and hydronephrosis when compared to the control group (non-overweight-untreated group). Sibutramine is related to the incidence of visceral anomalies, which suggests that there is teratogeny in rats due to this drug. Supported by CAPES/DS. (poster)" @default.
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• W2129351690 date "2011-07-01" @default.
• W2129351690 modified "2023-10-14" @default.
• W2129351690 title "May Sibutramine Treatment Causes Visceral Anomalies in the Progeny of Overweight and Nonoverweight Female Rats?" @default.
• W2129351690 doi "https://doi.org/10.1093/biolreprod/85.s1.796" @default.
• W2129351690 hasPublicationYear "2011" @default.
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