FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129353053> ?p ?o ?g. }

• W2129353053 endingPage "2525" @default.
• W2129353053 startingPage "2513" @default.
• W2129353053 abstract "Metazoan replication-dependent histone mRNAs end in a stem-loop sequence. The one known exception is the histone mRNA in amphibian oocytes, which has a short oligo(A) tail attached to the stem-loop sequence. Amphibian oocytes also contain two proteins that bind the 3′ end of histone mRNA: xSLBP1, the homologue of the mammalian SLBP, and xSLBP2, which is present only in oocytes. xSLBP2 is an inhibitor of histone mRNA translation, while xSLBP1 activates translation. The short A tail on histone mRNAs appears at stage II to III of oogenesis and is present on histone mRNAs throughout the rest of oogenesis. At oocyte maturation, the oligo(A) tail is removed and the xSLBP2 is degraded, resulting in the activation of translation of histone mRNA. Both SLBPs bind to the stem-loop with the oligo(A) tail with similar affinities. Reporter mRNAs ending in the stem-loop with or without the oligo(A) tail are translated equally well in a reticulocyte lysate, and their translation is stimulated by the presence of xSLBP1. In contrast, translation of the reporter mRNA with an oligo(A) tail is not activated in frog oocytes in response to the presence of xSLBP1. These results suggest that the oligo(A) tail is an active part of the translation repression mechanism that silences histone mRNA during oogenesis and that its removal is part of the mechanism that activates translation." @default.
• W2129353053 created "2016-06-24" @default.
• W2129353053 creator A5047703823 @default.
• W2129353053 creator A5077347833 @default.
• W2129353053 date "2004-03-01" @default.
• W2129353053 modified "2023-09-26" @default.
• W2129353053 title "The Oligo(A) Tail on Histone mRNA Plays an Active Role in Translational Silencing of Histone mRNA during <i>Xenopus</i> Oogenesis" @default.
• W2129353053 cites W1557157286 @default.
• W2129353053 cites W1591026223 @default.
• W2129353053 cites W1593594022 @default.
• W2129353053 cites W177280810 @default.
• W2129353053 cites W1799386426 @default.
• W2129353053 cites W1964480889 @default.
• W2129353053 cites W1969748543 @default.
• W2129353053 cites W1976727579 @default.
• W2129353053 cites W1979322942 @default.
• W2129353053 cites W1981517335 @default.
• W2129353053 cites W1986699200 @default.
• W2129353053 cites W1986932375 @default.
• W2129353053 cites W1990016695 @default.
• W2129353053 cites W1990118065 @default.
• W2129353053 cites W1999765420 @default.
• W2129353053 cites W2003542182 @default.
• W2129353053 cites W2010088075 @default.
• W2129353053 cites W2013865248 @default.
• W2129353053 cites W2020530697 @default.
• W2129353053 cites W2027300279 @default.
• W2129353053 cites W2029953457 @default.
• W2129353053 cites W2047733032 @default.
• W2129353053 cites W2050601734 @default.
• W2129353053 cites W2057475351 @default.
• W2129353053 cites W2059072211 @default.
• W2129353053 cites W2069930342 @default.
• W2129353053 cites W2080872485 @default.
• W2129353053 cites W2087465471 @default.
• W2129353053 cites W2089482316 @default.
• W2129353053 cites W2103431676 @default.
• W2129353053 cites W2104183138 @default.
• W2129353053 cites W2146943057 @default.
• W2129353053 cites W2150448516 @default.
• W2129353053 cites W2151872074 @default.
• W2129353053 cites W2152146470 @default.
• W2129353053 doi "https://doi.org/10.1128/mcb.24.6.2513-2525.2004" @default.
• W2129353053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/355835" @default.
• W2129353053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14993288" @default.
• W2129353053 hasPublicationYear "2004" @default.
• W2129353053 type Work @default.
• W2129353053 sameAs 2129353053 @default.
• W2129353053 citedByCount "21" @default.
• W2129353053 countsByYear W21293530532012 @default.
• W2129353053 countsByYear W21293530532013 @default.
• W2129353053 countsByYear W21293530532015 @default.
• W2129353053 countsByYear W21293530532018 @default.
• W2129353053 countsByYear W21293530532019 @default.
• W2129353053 countsByYear W21293530532021 @default.
• W2129353053 crossrefType "journal-article" @default.
• W2129353053 hasAuthorship W2129353053A5047703823 @default.
• W2129353053 hasAuthorship W2129353053A5077347833 @default.
• W2129353053 hasBestOaLocation W21293530531 @default.
• W2129353053 hasConcept C104317684 @default.
• W2129353053 hasConcept C105580179 @default.
• W2129353053 hasConcept C149364088 @default.
• W2129353053 hasConcept C153911025 @default.
• W2129353053 hasConcept C162419368 @default.
• W2129353053 hasConcept C2779085176 @default.
• W2129353053 hasConcept C2779535977 @default.
• W2129353053 hasConcept C54355233 @default.
• W2129353053 hasConcept C56428682 @default.
• W2129353053 hasConcept C64927066 @default.
• W2129353053 hasConcept C86803240 @default.
• W2129353053 hasConcept C95444343 @default.
• W2129353053 hasConceptScore W2129353053C104317684 @default.
• W2129353053 hasConceptScore W2129353053C105580179 @default.
• W2129353053 hasConceptScore W2129353053C149364088 @default.
• W2129353053 hasConceptScore W2129353053C153911025 @default.
• W2129353053 hasConceptScore W2129353053C162419368 @default.
• W2129353053 hasConceptScore W2129353053C2779085176 @default.
• W2129353053 hasConceptScore W2129353053C2779535977 @default.
• W2129353053 hasConceptScore W2129353053C54355233 @default.
• W2129353053 hasConceptScore W2129353053C56428682 @default.
• W2129353053 hasConceptScore W2129353053C64927066 @default.
• W2129353053 hasConceptScore W2129353053C86803240 @default.
• W2129353053 hasConceptScore W2129353053C95444343 @default.
• W2129353053 hasIssue "6" @default.
• W2129353053 hasLocation W21293530531 @default.
• W2129353053 hasLocation W21293530532 @default.
• W2129353053 hasLocation W21293530533 @default.
• W2129353053 hasLocation W21293530534 @default.
• W2129353053 hasOpenAccess W2129353053 @default.
• W2129353053 hasPrimaryLocation W21293530531 @default.
• W2129353053 hasRelatedWork W1545263810 @default.
• W2129353053 hasRelatedWork W1812995715 @default.
• W2129353053 hasRelatedWork W1964712285 @default.
• W2129353053 hasRelatedWork W2023978881 @default.
• W2129353053 hasRelatedWork W2058569508 @default.
• W2129353053 hasRelatedWork W2063360888 @default.
• W2129353053 hasRelatedWork W2071581153 @default.
• W2129353053 hasRelatedWork W2161859305 @default.

• next