Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129359002> ?p ?o ?g. }
- W2129359002 endingPage "31" @default.
- W2129359002 startingPage "18" @default.
- W2129359002 abstract "In the quest of ways for rationalizing and accelerating drug product development, integrated pharmacokinetic/pharmacodynamic (PK/PD) concepts provide a highly promising tool. PK/PD modeling concepts can be applied in all stages of preclinical and clinical drug development, and their benefits are multifold. At the preclinical stage, potential applications might comprise the evaluation of in vivo potency and intrinsic activity, the identification of bio-/surrogate markers, as well as dosage form and regimen selection and optimization. At the clinical stage, analytical PK/PD applications include characterization of the dose-concentration-effect/toxicity relationship, evaluation of food, age and gender effects, drug/drug and drug/disease interactions, tolerance development, and inter- and intraindividual variability in response. Predictive PK/PD applications can also involve extrapolation from preclinical data, simulation of drug responses, as well as clinical trial forecasting. Rigorous implementation of the PK/PD concepts in drug product development provides a rationale, scientifically based framework for efficient decision making regarding the selection of potential drug candidates, for maximum information gain from the performed experiments and studies, and for conducting fewer, more focused clinical trials with improved efficiency and cost effectiveness. Thus, PK/PD concepts are believed to play a pivotal role in streamlining the drug development process of the future." @default.
- W2129359002 created "2016-06-24" @default.
- W2129359002 creator A5058057231 @default.
- W2129359002 creator A5078634243 @default.
- W2129359002 date "2002-01-01" @default.
- W2129359002 modified "2023-09-30" @default.
- W2129359002 title "Pharmacokinetic/Pharmacodynamic Studies in Drug Product Development" @default.
- W2129359002 cites W1517386226 @default.
- W2129359002 cites W1554414628 @default.
- W2129359002 cites W1557181127 @default.
- W2129359002 cites W1576352184 @default.
- W2129359002 cites W1580151160 @default.
- W2129359002 cites W1591219715 @default.
- W2129359002 cites W1593996974 @default.
- W2129359002 cites W1817907600 @default.
- W2129359002 cites W182669748 @default.
- W2129359002 cites W1941410407 @default.
- W2129359002 cites W196087688 @default.
- W2129359002 cites W1963773346 @default.
- W2129359002 cites W1967819133 @default.
- W2129359002 cites W1970166126 @default.
- W2129359002 cites W1970387118 @default.
- W2129359002 cites W1973944605 @default.
- W2129359002 cites W1981535286 @default.
- W2129359002 cites W1982555108 @default.
- W2129359002 cites W1990289672 @default.
- W2129359002 cites W1992894877 @default.
- W2129359002 cites W1996253652 @default.
- W2129359002 cites W1998372894 @default.
- W2129359002 cites W1998519118 @default.
- W2129359002 cites W2001525541 @default.
- W2129359002 cites W2003666961 @default.
- W2129359002 cites W2003883797 @default.
- W2129359002 cites W2004140929 @default.
- W2129359002 cites W2005483003 @default.
- W2129359002 cites W2005887995 @default.
- W2129359002 cites W2007983074 @default.
- W2129359002 cites W2008596887 @default.
- W2129359002 cites W2012293219 @default.
- W2129359002 cites W2015399502 @default.
- W2129359002 cites W2015816350 @default.
- W2129359002 cites W2020259731 @default.
- W2129359002 cites W2020400312 @default.
- W2129359002 cites W2021020046 @default.
- W2129359002 cites W2024687868 @default.
- W2129359002 cites W2024951267 @default.
- W2129359002 cites W2025678650 @default.
- W2129359002 cites W2036629442 @default.
- W2129359002 cites W2042565844 @default.
- W2129359002 cites W2044239953 @default.
- W2129359002 cites W2056768996 @default.
- W2129359002 cites W2068955341 @default.
- W2129359002 cites W2071889852 @default.
- W2129359002 cites W2082515490 @default.
- W2129359002 cites W2084898581 @default.
- W2129359002 cites W2091458190 @default.
- W2129359002 cites W2105061380 @default.
- W2129359002 cites W2107437418 @default.
- W2129359002 cites W2112036649 @default.
- W2129359002 cites W2116855266 @default.
- W2129359002 cites W2121254446 @default.
- W2129359002 cites W2124561517 @default.
- W2129359002 cites W2126025637 @default.
- W2129359002 cites W2133728798 @default.
- W2129359002 cites W2135117144 @default.
- W2129359002 cites W2135126857 @default.
- W2129359002 cites W2135420205 @default.
- W2129359002 cites W2138957803 @default.
- W2129359002 cites W2139629662 @default.
- W2129359002 cites W2140604471 @default.
- W2129359002 cites W2143217914 @default.
- W2129359002 cites W2151553994 @default.
- W2129359002 cites W2151729293 @default.
- W2129359002 cites W2165405120 @default.
- W2129359002 cites W2184136371 @default.
- W2129359002 cites W2208152766 @default.
- W2129359002 cites W2315155350 @default.
- W2129359002 cites W2320917327 @default.
- W2129359002 cites W2328032908 @default.
- W2129359002 cites W2329258414 @default.
- W2129359002 cites W2488700677 @default.
- W2129359002 cites W290729494 @default.
- W2129359002 cites W347613371 @default.
- W2129359002 cites W4248558643 @default.
- W2129359002 cites W4255192009 @default.
- W2129359002 cites W92876359 @default.
- W2129359002 doi "https://doi.org/10.1002/jps.1167" @default.
- W2129359002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11782894" @default.
- W2129359002 hasPublicationYear "2002" @default.
- W2129359002 type Work @default.
- W2129359002 sameAs 2129359002 @default.
- W2129359002 citedByCount "137" @default.
- W2129359002 countsByYear W21293590022012 @default.
- W2129359002 countsByYear W21293590022013 @default.
- W2129359002 countsByYear W21293590022014 @default.
- W2129359002 countsByYear W21293590022015 @default.
- W2129359002 countsByYear W21293590022016 @default.
- W2129359002 countsByYear W21293590022017 @default.