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- W2129379145 abstract "<b>Objective: </b> To investigate the stability and time course of human CSF amyloid-β (Aβ) levels over hours. <b>Methods: </b> Fifteen nondemented participants had CSF sampled hourly for up to 36 hours via indwelling lumbar catheter. CSF Aβ<sub>1-x</sub>, Aβ<sub>1-40</sub>, and Aβ<sub>1-42</sub> were measured by ELISA in each hourly CSF sample. <b>Results: </b> Significant variation in Aβ levels of 1.5- to fourfold was detected over 36 hours of serially sampling in individual subjects. Aβ<sub>40</sub>, Aβ<sub>42</sub>, and Aβ<sub>1-X</sub> are highly correlated over time indicating that similar processes likely regulate the level of these species. On average, the fluctuations of Aβ levels appear to be time of day or activity dependent. <b>Conclusion: </b> Diagnostic and therapeutic trials that measure Aβ should control for the time of CSF sampling to minimize variability." @default.
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- W2129379145 date "2007-02-26" @default.
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- W2129379145 title "Fluctuations of CSF amyloid-ss levels: Implications for a diagnostic and therapeutic biomarker" @default.
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- W2129379145 doi "https://doi.org/10.1212/01.wnl.0000256043.50901.e3" @default.
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