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- W2129391657 abstract "We have shown previously that auditory experience regulates the maturation of excitatory synapses in the auditory cortex (ACx). In this study, we used electron microscopic immunocytochemistry to determine whether the heightened excitability of the ACx following neonatal sensorineural hearing loss (SNHL) also involves pre- or postsynaptic alterations of GABAergic synapses. SNHL was induced in gerbils just prior to the onset of hearing (postnatal day 10). At P17, the gamma-aminobutyri acid type A (GABAA) receptor's β2/3-subunit (GABAAβ2/3) clusters residing at plasma membranes in layers 2/3 of ACx was reduced significantly in size (P < 0.05) and number (P < 0.005), whereas the overall number of immunoreactive puncta (intracellular + plasmalemmal) remained unchanged. The reduction of GABAAβ2/3 was observed along perikaryal plasma membranes of excitatory neurons but not of GABAergic interneurons. This cell-specific change can contribute to the enhanced excitability of SNHL ACx. Presynaptically, GABAergic axon terminals were significantly larger but less numerous and contained 47% greater density of glutamic acid decarboxylase immunoreactivity (P < 0.05). This suggests that GABA synthesis may be upregulated by a retrograde signal arising from lowered levels of postsynaptic GABAAR. Thus, both, the pre- and postsynaptic sides of inhibitory synapses that form upon pyramidal neurons of the ACx are regulated by neonatal auditory experience." @default.
- W2129391657 created "2016-06-24" @default.
- W2129391657 creator A5050436328 @default.
- W2129391657 creator A5052055467 @default.
- W2129391657 creator A5057301981 @default.
- W2129391657 creator A5086675924 @default.
- W2129391657 date "2008-04-09" @default.
- W2129391657 modified "2023-10-15" @default.
- W2129391657 title "Hearing Loss Alters the Subcellular Distribution of Presynaptic GAD and Postsynaptic GABAA Receptors in the Auditory Cortex" @default.
- W2129391657 cites W1480770914 @default.
- W2129391657 cites W1499258600 @default.
- W2129391657 cites W1512233152 @default.
- W2129391657 cites W1522096759 @default.
- W2129391657 cites W1524203275 @default.
- W2129391657 cites W1538269477 @default.
- W2129391657 cites W1553149131 @default.
- W2129391657 cites W1584878961 @default.
- W2129391657 cites W1825905345 @default.
- W2129391657 cites W1921741715 @default.
- W2129391657 cites W1937675039 @default.
- W2129391657 cites W1944141667 @default.
- W2129391657 cites W1948082071 @default.
- W2129391657 cites W1963925096 @default.
- W2129391657 cites W1968037117 @default.
- W2129391657 cites W1970303222 @default.
- W2129391657 cites W1971402245 @default.
- W2129391657 cites W1974022934 @default.
- W2129391657 cites W1986463724 @default.
- W2129391657 cites W1986476780 @default.
- W2129391657 cites W1987906661 @default.
- W2129391657 cites W1987992019 @default.
- W2129391657 cites W1988651706 @default.
- W2129391657 cites W1994261508 @default.
- W2129391657 cites W1996809637 @default.
- W2129391657 cites W1997437840 @default.
- W2129391657 cites W2001352204 @default.
- W2129391657 cites W2007532471 @default.
- W2129391657 cites W2010687489 @default.
- W2129391657 cites W2012509286 @default.
- W2129391657 cites W2014312794 @default.
- W2129391657 cites W2017067141 @default.
- W2129391657 cites W2017723736 @default.
- W2129391657 cites W2019417149 @default.
- W2129391657 cites W2024486726 @default.
- W2129391657 cites W2030626955 @default.
- W2129391657 cites W2033602348 @default.
- W2129391657 cites W2036705170 @default.
- W2129391657 cites W2037060419 @default.
- W2129391657 cites W2037313792 @default.
- W2129391657 cites W2037524295 @default.
- W2129391657 cites W2037923901 @default.
- W2129391657 cites W2042604124 @default.
- W2129391657 cites W2043233340 @default.
- W2129391657 cites W2048882295 @default.
- W2129391657 cites W2049771463 @default.
- W2129391657 cites W2053358664 @default.
- W2129391657 cites W2055792991 @default.
- W2129391657 cites W2058106424 @default.
- W2129391657 cites W2059740415 @default.
- W2129391657 cites W2060300312 @default.
- W2129391657 cites W2060929383 @default.
- W2129391657 cites W2062813684 @default.
- W2129391657 cites W2064495359 @default.
- W2129391657 cites W2065154130 @default.
- W2129391657 cites W2065178022 @default.
- W2129391657 cites W2069135580 @default.
- W2129391657 cites W2070776139 @default.
- W2129391657 cites W2073253722 @default.
- W2129391657 cites W2079167279 @default.
- W2129391657 cites W2079746759 @default.
- W2129391657 cites W2080811299 @default.
- W2129391657 cites W2080882577 @default.
- W2129391657 cites W2081052063 @default.
- W2129391657 cites W2085612074 @default.
- W2129391657 cites W2085850097 @default.
- W2129391657 cites W2085955152 @default.
- W2129391657 cites W2089510435 @default.
- W2129391657 cites W2090521204 @default.
- W2129391657 cites W2101457206 @default.
- W2129391657 cites W2106001183 @default.
- W2129391657 cites W2130126327 @default.
- W2129391657 cites W2131311587 @default.
- W2129391657 cites W2132434189 @default.
- W2129391657 cites W2136115516 @default.
- W2129391657 cites W2141883363 @default.
- W2129391657 cites W2145791439 @default.
- W2129391657 cites W2149377066 @default.
- W2129391657 cites W2150285951 @default.
- W2129391657 cites W2153190436 @default.
- W2129391657 cites W2176076159 @default.
- W2129391657 cites W2247478967 @default.
- W2129391657 cites W2289466687 @default.
- W2129391657 cites W2409197997 @default.
- W2129391657 cites W2520800626 @default.
- W2129391657 cites W4321429493 @default.
- W2129391657 doi "https://doi.org/10.1093/cercor/bhn044" @default.
- W2129391657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2583158" @default.
- W2129391657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18403398" @default.