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- W2129404211 abstract "BackgroundThe use of biological-based markers of exposure, intermediate effect, outcome, and susceptibility has become standard practice in cancer epidemiology, which has contributed to identification of several carcinogenic agents. Nevertheless, with the exception of biological agents, this contribution, in terms of providing sufficiently strong evidence as required by the International Agency for Research on Cancer (IARC) monographs, has been modest.Materials and methodsWe discuss the overall contribution of molecular epidemiology to identification of carcinogens, with focus on IARC monographs.ResultsFor many carcinogens, valid biological markers of exposure and mechanisms of actions are not available. Molecular markers are usually assessed in single biological samples, which may not represent the actual exposure or biological events related to carcinogens. The contribution of molecular epidemiology to identification of carcinogens has mainly been limited to the carcinogens acting through a genotoxic mechanism, i.e. when carcinogens induce DNA damage. A number of factors, including certain hormones and overweight/obesity, may show carcinogenic effects through nongenotoxic pathways, for which mechanisms of carcinogenicity are not well identified and their biomarkers are sparse.ConclusionLongitudinal assessment of biomarkers may provide more informative data in molecular epidemiology studies. For many carcinogens and mechanistic pathways, in particular nongenotoxic carcinogenicity, valid biological markers still need to be identified." @default.
- W2129404211 created "2016-06-24" @default.
- W2129404211 creator A5021007602 @default.
- W2129404211 creator A5031129631 @default.
- W2129404211 date "2013-04-01" @default.
- W2129404211 modified "2023-09-28" @default.
- W2129404211 title "The contribution of molecular epidemiology to the identification of human carcinogens: current status and future perspectives" @default.
- W2129404211 cites W134923470 @default.
- W2129404211 cites W1597704210 @default.
- W2129404211 cites W1640635403 @default.
- W2129404211 cites W1964294501 @default.
- W2129404211 cites W1964785359 @default.
- W2129404211 cites W1972047775 @default.
- W2129404211 cites W1981592676 @default.
- W2129404211 cites W1983832776 @default.
- W2129404211 cites W1986076152 @default.
- W2129404211 cites W1986396604 @default.
- W2129404211 cites W1993957210 @default.
- W2129404211 cites W1996796890 @default.
- W2129404211 cites W1998637589 @default.
- W2129404211 cites W2000609910 @default.
- W2129404211 cites W2001645859 @default.
- W2129404211 cites W2004774286 @default.
- W2129404211 cites W2011152373 @default.
- W2129404211 cites W2016401533 @default.
- W2129404211 cites W2026199471 @default.
- W2129404211 cites W2032438721 @default.
- W2129404211 cites W2036953884 @default.
- W2129404211 cites W2041586097 @default.
- W2129404211 cites W2043843367 @default.
- W2129404211 cites W2046463062 @default.
- W2129404211 cites W2047015636 @default.
- W2129404211 cites W2047810781 @default.
- W2129404211 cites W2051765493 @default.
- W2129404211 cites W2052028397 @default.
- W2129404211 cites W2052178019 @default.
- W2129404211 cites W2059122605 @default.
- W2129404211 cites W2064844197 @default.
- W2129404211 cites W2065240048 @default.
- W2129404211 cites W2065313351 @default.
- W2129404211 cites W2066847395 @default.
- W2129404211 cites W2068063700 @default.
- W2129404211 cites W2068732691 @default.
- W2129404211 cites W2073495046 @default.
- W2129404211 cites W2073576377 @default.
- W2129404211 cites W2077633288 @default.
- W2129404211 cites W2080055659 @default.
- W2129404211 cites W2082592723 @default.
- W2129404211 cites W2082897011 @default.
- W2129404211 cites W2083695927 @default.
- W2129404211 cites W2086678451 @default.
- W2129404211 cites W2088428578 @default.
- W2129404211 cites W2091209259 @default.
- W2129404211 cites W2091535349 @default.
- W2129404211 cites W2097989455 @default.
- W2129404211 cites W2105016775 @default.
- W2129404211 cites W2112001893 @default.
- W2129404211 cites W2117442262 @default.
- W2129404211 cites W2126673711 @default.
- W2129404211 cites W2129629007 @default.
- W2129404211 cites W2129899300 @default.
- W2129404211 cites W2130251223 @default.
- W2129404211 cites W2132607882 @default.
- W2129404211 cites W2133567607 @default.
- W2129404211 cites W2138649409 @default.
- W2129404211 cites W2143677025 @default.
- W2129404211 cites W2148910409 @default.
- W2129404211 cites W2149312363 @default.
- W2129404211 cites W2155806032 @default.
- W2129404211 cites W2163431996 @default.
- W2129404211 cites W2165391989 @default.
- W2129404211 cites W2171326022 @default.
- W2129404211 cites W2319055243 @default.
- W2129404211 cites W2321415533 @default.
- W2129404211 cites W4242564129 @default.
- W2129404211 cites W4248878862 @default.
- W2129404211 doi "https://doi.org/10.1093/annonc/mds543" @default.
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