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- W2129404677 abstract "Methotrexate is widely accepted as a highly efficacious treatment for severe psorias is . Its most important long-term side effect, and one which has limited its use in treating this disorder, is hepatic cirrhosis . The indications for and utility of pretreatment and follow-up liver biopsies in patients receiving methotrexate remain unresolved, although it has been established that liver function tests are an unreliable indicator of hepatic damage , which often can be ascertained .only by liver biopsy. Several studies have recently been published in an effort to better identify patients at risk for methotrexate-induced liver disease. Zachariae et all found histologic evidence of cirrhosis in ten of thirty-nine patients treated with methotrexate for greater than 5 years. Most were on a divided dose intermittent oral dosage schedule. Liver enzyme examinations disclosed only transient abnormalities. The cumulative dose at which cirrho sis was first found ranged from 590 to 8 ,105 mg of methotrexate, with an average dosage of 2,200 mg. Compromised renal function, previous intake of alcohol, and previous treatment with arsenic seemed to increase the risk of developing methotrexate-induced cirrhosis . Interestingly , the cirrhosis did not appear to be progressive, as the liver disease actually improved or disappeared in several patients allowed to continue on the drug because of severe disabling psoriasis." @default.
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- W2129404677 date "1981-04-01" @default.
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- W2129404677 title "Hazards of therapy" @default.
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- W2129404677 doi "https://doi.org/10.1016/s0190-9622(81)80272-1" @default.
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