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- W2129442068 endingPage "676" @default.
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- W2129442068 abstract "It is known that cardiopulmonary bypass causes an inflammatory reaction with an associated morbidity and mortality. Several anti-inflammatory strategies have been implemented to reduce this response, including leukocyte removal from the circulation using specialised filters. The aim of this study is to systematically review the available evidence on leukocyte filtration in cardiac surgery, focusing on its effect on systemic inflammation and whether this has influenced clinical outcomes. Five electronic databases were systematically searched for studies reporting the effect of leukocyte filtration at any point within the cardiopulmonary bypass circuit in humans. Reference lists of all identified studies were checked for any missing publications. Two authors independently extracted the data from the included studies. Whilst systemic leukodepleting filters do not appear to consistently lower leukocyte counts, they may preferentially remove activated leukocytes. Small improvements in early post-operative lung function in patients receiving systemic leukodepletion have been reported, but this does not lead to reduced hospital stay or decreased mortality. There is substantial evidence that cardioplegic leukocyte filtration attenuates the reperfusion injury at a cellular level, but this has not been translated into clinical improvements. Finally, whilst various strategies involving multiple leukocyte filters, or the incorporation of pharmacological agents into leukocyte-depleting protocols have been evaluated, the current available results are not conclusive. Our study suggests that there is not enough high quality or consistent evidence to draw guidelines regarding the use of leukocyte-depleting filters within routine cardiac surgical practice." @default.
- W2129442068 created "2016-06-24" @default.
- W2129442068 creator A5027773961 @default.
- W2129442068 creator A5031176491 @default.
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- W2129442068 creator A5057401678 @default.
- W2129442068 creator A5070469370 @default.
- W2129442068 creator A5075017317 @default.
- W2129442068 date "2007-04-01" @default.
- W2129442068 modified "2023-09-26" @default.
- W2129442068 title "The effects of various leukocyte filtration strategies in cardiac surgery" @default.
- W2129442068 cites W1732680788 @default.
- W2129442068 cites W182126834 @default.
- W2129442068 cites W1964771989 @default.
- W2129442068 cites W1966505150 @default.
- W2129442068 cites W1970628888 @default.
- W2129442068 cites W1972950515 @default.
- W2129442068 cites W1974370167 @default.
- W2129442068 cites W1974447152 @default.
- W2129442068 cites W1977714832 @default.
- W2129442068 cites W1982435133 @default.
- W2129442068 cites W1983126084 @default.
- W2129442068 cites W1983389143 @default.
- W2129442068 cites W1987078321 @default.
- W2129442068 cites W1994369458 @default.
- W2129442068 cites W1998508664 @default.
- W2129442068 cites W1999415288 @default.
- W2129442068 cites W2003199716 @default.
- W2129442068 cites W2008181975 @default.
- W2129442068 cites W2010920072 @default.
- W2129442068 cites W2014657381 @default.
- W2129442068 cites W2015096657 @default.
- W2129442068 cites W2018695964 @default.
- W2129442068 cites W2022477911 @default.
- W2129442068 cites W2023127291 @default.
- W2129442068 cites W2024827060 @default.
- W2129442068 cites W2029685468 @default.
- W2129442068 cites W2031419081 @default.
- W2129442068 cites W2031486231 @default.
- W2129442068 cites W2031871304 @default.
- W2129442068 cites W2032792452 @default.
- W2129442068 cites W2034189468 @default.
- W2129442068 cites W2035146976 @default.
- W2129442068 cites W2035173385 @default.
- W2129442068 cites W2035790487 @default.
- W2129442068 cites W2036855384 @default.
- W2129442068 cites W2039932719 @default.
- W2129442068 cites W2042601167 @default.
- W2129442068 cites W2045786699 @default.
- W2129442068 cites W2046294430 @default.
- W2129442068 cites W2047619992 @default.
- W2129442068 cites W2048470272 @default.
- W2129442068 cites W2050054603 @default.
- W2129442068 cites W2050323227 @default.
- W2129442068 cites W2056421724 @default.
- W2129442068 cites W2058974875 @default.
- W2129442068 cites W2059626268 @default.
- W2129442068 cites W2060005877 @default.
- W2129442068 cites W2060536639 @default.
- W2129442068 cites W2060867801 @default.
- W2129442068 cites W2063406568 @default.
- W2129442068 cites W2063624781 @default.
- W2129442068 cites W2066530848 @default.
- W2129442068 cites W2070803389 @default.
- W2129442068 cites W2071480246 @default.
- W2129442068 cites W2072963926 @default.
- W2129442068 cites W2074095696 @default.
- W2129442068 cites W2074499520 @default.
- W2129442068 cites W2086353136 @default.
- W2129442068 cites W2089456633 @default.
- W2129442068 cites W2090050525 @default.
- W2129442068 cites W2093241303 @default.
- W2129442068 cites W2101363891 @default.
- W2129442068 cites W2104089903 @default.
- W2129442068 cites W2105366913 @default.
- W2129442068 cites W2114270095 @default.
- W2129442068 cites W2116668384 @default.
- W2129442068 cites W2124162052 @default.
- W2129442068 cites W2126731653 @default.
- W2129442068 cites W2132543335 @default.
- W2129442068 cites W2135148473 @default.
- W2129442068 cites W2145414558 @default.
- W2129442068 cites W2146227413 @default.
- W2129442068 cites W2150583859 @default.
- W2129442068 cites W2154329627 @default.
- W2129442068 cites W2155747958 @default.
- W2129442068 cites W2166127057 @default.
- W2129442068 cites W2313608791 @default.
- W2129442068 cites W2316490854 @default.
- W2129442068 cites W2395474442 @default.
- W2129442068 cites W2406342922 @default.
- W2129442068 cites W2413040204 @default.
- W2129442068 cites W2419508721 @default.
- W2129442068 cites W2432693155 @default.
- W2129442068 cites W25128727 @default.
- W2129442068 cites W2526003261 @default.