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- W2129444805 abstract "We examined the effect of a clinically detectable patent ductus arteriosus (PDA) and its successful treatment with indomethacin on serial measures of pulmonary mechanics in 10 very-low-birthweight (VLBW) intubated infants with respiratory distress syndrome (RDS). Pulmonary mechanics were measured by the passive expiratory flow technique. Total respiratory system compliance (Crs) gradually improved as RDS resolved. However, a significant decrease in mean Crs was associated with the development of a clinically detectable PDA, ranging from 1.51 ± 0.21 to 0.90 ± 0.08 mL/cmH2O/m (P < 0.05). We also noted an increase in mean Crs, from 0.90 ± 0.08 to 1.49 ± 0.21 mL/cmH2O/m (P < 0.05), after successful treatment of a PDA with indomethacin. Total respiratory system resistance (Rrs) did not change. We conclude that a clinically significant PDA is associated with a decreased Crs and that successful treatment of a PDA with indomethacin is associated with an improvement in lung compliance. These findings imply that the development of a clinically detectable PDA and its subsequent treatment complicates the interpretation of pulmonary mechanics data in VLBW infants with RDS." @default.
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- W2129444805 date "1991-01-01" @default.
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- W2129444805 title "Effects of a clinically detectable PDA on pulmonary mechanics measures in VLBW infants with RDS" @default.
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- W2129444805 doi "https://doi.org/10.1002/ppul.1950110214" @default.
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