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• W2129448596 abstract "The goal of this work was to assess statistical power to detect treatment effects in Alzheimer's disease (AD) clinical trials using magnetic resonance imaging (MRI)-derived brain biomarkers. We used unbiased tensor-based morphometry (TBM) to analyze n = 5,738 scans, from Alzheimer's Disease Neuroimaging Initiative 2 participants scanned with both accelerated and nonaccelerated T1-weighted MRI at 3T. The study cohort included 198 healthy controls, 111 participants with significant memory complaint, 182 with early mild cognitive impairment (EMCI) and 177 late mild cognitive impairment (LMCI), and 155 AD patients, scanned at screening and 3, 6, 12, and 24 months. The statistical power to track brain change in TBM-based imaging biomarkers depends on the interscan interval, disease stage, and methods used to extract numerical summaries. To achieve reasonable sample size estimates for potential clinical trials, the minimal scan interval was 6 months for LMCI and AD and 12 months for EMCI. TBM-based imaging biomarkers were not sensitive to MRI scan acceleration, which gave results comparable with nonaccelerated sequences. ApoE status and baseline amyloid-beta positron emission tomography data improved statistical power. Among healthy, EMCI, and LMCI participants, sample size requirements were significantly lower in the amyloid+/ApoE4+ group than for the amyloid-/ApoE4- group. ApoE4 strongly predicted atrophy rates across brain regions most affected by AD, but the remaining 9 of the top 10 AD risk genes offered no added predictive value in this cohort." @default.
• W2129448596 created "2016-06-24" @default.
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• W2129448596 date "2016-01-01" @default.
• W2129448596 modified "2023-10-17" @default.
• W2129448596 title "MRI-based brain atrophy rates in ADNI phase 2: acceleration and enrichment considerations for clinical trials" @default.
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• W2129448596 cites W1993571512 @default.
• W2129448596 cites W1995386242 @default.
• W2129448596 cites W2001477615 @default.
• W2129448596 cites W2001666669 @default.
• W2129448596 cites W2005133023 @default.
• W2129448596 cites W2006557707 @default.
• W2129448596 cites W2007044705 @default.
• W2129448596 cites W2008152557 @default.
• W2129448596 cites W2009739635 @default.
• W2129448596 cites W2009870816 @default.
• W2129448596 cites W2010280952 @default.
• W2129448596 cites W2011402106 @default.
• W2129448596 cites W2012133068 @default.
• W2129448596 cites W2023485724 @default.
• W2129448596 cites W2030176492 @default.
• W2129448596 cites W2031448494 @default.
• W2129448596 cites W2032977736 @default.
• W2129448596 cites W2034406508 @default.
• W2129448596 cites W2034670014 @default.
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• W2129448596 cites W2038899746 @default.
• W2129448596 cites W2040016992 @default.
• W2129448596 cites W2044614452 @default.
• W2129448596 cites W2044941609 @default.
• W2129448596 cites W2045867209 @default.
• W2129448596 cites W2049105183 @default.
• W2129448596 cites W2056733711 @default.
• W2129448596 cites W2056898461 @default.
• W2129448596 cites W2063808031 @default.
• W2129448596 cites W2064222308 @default.
• W2129448596 cites W2064530236 @default.
• W2129448596 cites W2075057648 @default.
• W2129448596 cites W2082429191 @default.
• W2129448596 cites W2086978209 @default.
• W2129448596 cites W2087964262 @default.
• W2129448596 cites W2093022413 @default.
• W2129448596 cites W2094952053 @default.
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• W2129448596 cites W2129047299 @default.
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• W2129448596 cites W2141796362 @default.
• W2129448596 cites W2143895814 @default.
• W2129448596 cites W2145661921 @default.
• W2129448596 cites W2146249493 @default.
• W2129448596 cites W2149142893 @default.
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• W2129448596 cites W2152634927 @default.
• W2129448596 cites W2154778070 @default.
• W2129448596 cites W2156311276 @default.
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• W2129448596 cites W4211007605 @default.
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• W2129448596 doi "https://doi.org/10.1016/j.neurobiolaging.2015.09.018" @default.
• W2129448596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4827255" @default.
• W2129448596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26545631" @default.
• W2129448596 hasPublicationYear "2016" @default.
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