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• W2129463462 abstract "The purpose of this study was to investigate whether a polymorphism in the matrix metalloproteinase-12 gene ( MMP-12 −82A/G) is correlated with serum protein levels or with the susceptibility for carotid plaques in the Chinese Han population. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed on the −82A/G polymorphism in the MMP-12 gene for 1314 patients with acute cerebral infarctions; 710 of these cases were diagnosed with stable plaques, 340 cases were diagnosed with vulnerable plaques and 264 cases had no plaques. At the same time, serum MMP-12 levels were measured using the enzyme-linked immunosorbent assay (ELISA). Compared to the AA genotype, the frequency of the AG+GG genotypes was not significantly different between the three groups (χ 2 = 1.242, p = 0.537), and the frequency of the G allele of the MMP-12 gene was not different within the three subgroups (χ 2 = 1.218, p = 0.544). There were no significant differences in MMP-12 protein levels among the three groups (F = 0.675, p = 0.510); similarly, there was no difference in MMP-12 protein levels between the stable plaque group and the vulnerable plaque group ( p = 0.755). There was also no difference between the vulnerable plaque group and the no plaque group ( p = 0.420). The current data suggest that the inter-individual variability in the MMP-12 gene variation may not be a risk factor for vulnerable plaques in the Chinese Han population." @default.
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• W2129463462 date "2012-08-03" @default.
• W2129463462 modified "2023-10-17" @default.
• W2129463462 title "Lack of independent relationship between the <i>MMP-12</i> gene polymorphism and carotid plaque susceptibility in the Chinese Han population" @default.
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• W2129463462 doi "https://doi.org/10.1177/1358863x12451513" @default.
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