Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129504003> ?p ?o ?g. }
- W2129504003 endingPage "1505" @default.
- W2129504003 startingPage "1498" @default.
- W2129504003 abstract "As whole-genome sequencing becomes commoditized and we begin to sequence and analyze personal genomes for clinical and diagnostic purposes, it is necessary to understand what constitutes a complete sequencing experiment for determining genotypes and detecting single-nucleotide variants. Here, we show that the current recommendation of ∼30× coverage is not adequate to produce genotype calls across a large fraction of the genome with acceptably low error rates. Our results are based on analyses of a clinical sample sequenced on two related Illumina platforms, GAII x and HiSeq 2000, to a very high depth (126×). We used these data to establish genotype-calling filters that dramatically increase accuracy. We also empirically determined how the callable portion of the genome varies as a function of the amount of sequence data used. These results help provide a “sequencing guide” for future whole-genome sequencing decisions and metrics by which coverage statistics should be reported." @default.
- W2129504003 created "2016-06-24" @default.
- W2129504003 creator A5013561821 @default.
- W2129504003 creator A5021932365 @default.
- W2129504003 creator A5032680165 @default.
- W2129504003 creator A5053925324 @default.
- W2129504003 creator A5054883884 @default.
- W2129504003 date "2011-07-19" @default.
- W2129504003 modified "2023-10-03" @default.
- W2129504003 title "Accurate and comprehensive sequencing of personal genomes" @default.
- W2129504003 cites W1965240564 @default.
- W2129504003 cites W1966711026 @default.
- W2129504003 cites W1993863888 @default.
- W2129504003 cites W2000905326 @default.
- W2129504003 cites W2001725958 @default.
- W2129504003 cites W2006085234 @default.
- W2129504003 cites W2012016911 @default.
- W2129504003 cites W2045160632 @default.
- W2129504003 cites W2049656505 @default.
- W2129504003 cites W2056554987 @default.
- W2129504003 cites W2058140004 @default.
- W2129504003 cites W2090144921 @default.
- W2129504003 cites W2103154918 @default.
- W2129504003 cites W2103441770 @default.
- W2129504003 cites W2108698786 @default.
- W2129504003 cites W2118246164 @default.
- W2129504003 cites W2118268786 @default.
- W2129504003 cites W2129089132 @default.
- W2129504003 cites W2138603354 @default.
- W2129504003 cites W2150677022 @default.
- W2129504003 cites W2158297569 @default.
- W2129504003 cites W2159965404 @default.
- W2129504003 cites W2160444236 @default.
- W2129504003 cites W2160825263 @default.
- W2129504003 cites W2168133698 @default.
- W2129504003 cites W2171777347 @default.
- W2129504003 cites W2549117626 @default.
- W2129504003 cites W2612812586 @default.
- W2129504003 doi "https://doi.org/10.1101/gr.123638.111" @default.
- W2129504003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3166834" @default.
- W2129504003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21771779" @default.
- W2129504003 hasPublicationYear "2011" @default.
- W2129504003 type Work @default.
- W2129504003 sameAs 2129504003 @default.
- W2129504003 citedByCount "184" @default.
- W2129504003 countsByYear W21295040032012 @default.
- W2129504003 countsByYear W21295040032013 @default.
- W2129504003 countsByYear W21295040032014 @default.
- W2129504003 countsByYear W21295040032015 @default.
- W2129504003 countsByYear W21295040032016 @default.
- W2129504003 countsByYear W21295040032017 @default.
- W2129504003 countsByYear W21295040032018 @default.
- W2129504003 countsByYear W21295040032019 @default.
- W2129504003 countsByYear W21295040032020 @default.
- W2129504003 countsByYear W21295040032021 @default.
- W2129504003 countsByYear W21295040032022 @default.
- W2129504003 countsByYear W21295040032023 @default.
- W2129504003 crossrefType "journal-article" @default.
- W2129504003 hasAuthorship W2129504003A5013561821 @default.
- W2129504003 hasAuthorship W2129504003A5021932365 @default.
- W2129504003 hasAuthorship W2129504003A5032680165 @default.
- W2129504003 hasAuthorship W2129504003A5053925324 @default.
- W2129504003 hasAuthorship W2129504003A5054883884 @default.
- W2129504003 hasBestOaLocation W21295040031 @default.
- W2129504003 hasConcept C104317684 @default.
- W2129504003 hasConcept C113425843 @default.
- W2129504003 hasConcept C141231307 @default.
- W2129504003 hasConcept C192953774 @default.
- W2129504003 hasConcept C205270622 @default.
- W2129504003 hasConcept C24103923 @default.
- W2129504003 hasConcept C24432333 @default.
- W2129504003 hasConcept C51679486 @default.
- W2129504003 hasConcept C54355233 @default.
- W2129504003 hasConcept C70721500 @default.
- W2129504003 hasConcept C86803240 @default.
- W2129504003 hasConceptScore W2129504003C104317684 @default.
- W2129504003 hasConceptScore W2129504003C113425843 @default.
- W2129504003 hasConceptScore W2129504003C141231307 @default.
- W2129504003 hasConceptScore W2129504003C192953774 @default.
- W2129504003 hasConceptScore W2129504003C205270622 @default.
- W2129504003 hasConceptScore W2129504003C24103923 @default.
- W2129504003 hasConceptScore W2129504003C24432333 @default.
- W2129504003 hasConceptScore W2129504003C51679486 @default.
- W2129504003 hasConceptScore W2129504003C54355233 @default.
- W2129504003 hasConceptScore W2129504003C70721500 @default.
- W2129504003 hasConceptScore W2129504003C86803240 @default.
- W2129504003 hasIssue "9" @default.
- W2129504003 hasLocation W21295040031 @default.
- W2129504003 hasLocation W21295040032 @default.
- W2129504003 hasLocation W21295040033 @default.
- W2129504003 hasLocation W21295040034 @default.
- W2129504003 hasLocation W21295040035 @default.
- W2129504003 hasOpenAccess W2129504003 @default.
- W2129504003 hasPrimaryLocation W21295040031 @default.
- W2129504003 hasRelatedWork W1725128978 @default.
- W2129504003 hasRelatedWork W180085294 @default.
- W2129504003 hasRelatedWork W2041379552 @default.
- W2129504003 hasRelatedWork W2107233609 @default.