FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2129553429> ?p ?o ?g. }

• W2129553429 endingPage "330" @default.
• W2129553429 startingPage "320" @default.
• W2129553429 abstract "To optimize strategies for liver-directed cell therapy, prevention of initial transplanted cell losses is particularly important for subsequent liver repopulation. After cell transplantation in hepatic sinusoids, perturbations in hepatic microcirculation along with changes in various liver cell types are among the earliest changes. Therefore, for advancing further concepts in cell engraftment we studied vascular and related events in the liver after transplanting syngeneic hepatocytes into dipeptidyl peptidase IV-deficient rats. We treated rats with vascular drugs to define whether deleterious cell transplantation-induced events could be controlled followed by improvements in transplanted cell engraftment and proliferation. We found cell transplantation altered liver gene expression related to vessel tone, inflammation, cell adhesion, thrombosis, or tissue damage/remodeling. This was due to hepatic ischemia, endothelial injury, and activation of neutrophils, Kupffer cells, and hepatic stellate cells. Treatment of rats before cell transplantation with the angiotensin converting enzyme blocker, lisinopril, or angiotensin II receptor blocker, losartan, did not improve cell engraftment. By contrast, direct-acting nitroglycerine or prostacyclin improved cell engraftment and also kinetics of liver repopulation. These drugs lowered hepatic ischemia and inflammation, whereas pretreatment of rats with the dual endothelin-1 receptor blocker, bosentan, improved cell engraftment independently of hepatic ischemia or inflammation, without improving liver repopulation. However, incubation of hepatocytes with bosentan protected cells from cytokine toxicity in vitro and produced superior cell engraftment and proliferation in vivo. Conclusion: Cell transplantation-induced changes in hepatic microcirculation contributed to transplanted cell clearances from liver. Vascular drugs, such as nitroglycerine, prostacyclin, and bosentan, offer opportunities for improving cell therapy results through superior cell engraftment and liver repopulation. Ongoing clinical use of these drugs will permit rapid translation of the findings in people. (HEPATOLOGY 2013)" @default.
• W2129553429 created "2016-06-24" @default.
• W2129553429 creator A5010035779 @default.
• W2129553429 creator A5053160478 @default.
• W2129553429 creator A5073819824 @default.
• W2129553429 creator A5077612245 @default.
• W2129553429 creator A5090461114 @default.
• W2129553429 creator A5091016060 @default.
• W2129553429 date "2013-01-01" @default.
• W2129553429 modified "2023-10-18" @default.
• W2129553429 title "Directly acting drugs prostacyclin or nitroglycerine and endothelin receptor blocker bosentan improve cell engraftment in rodent liver" @default.
• W2129553429 cites W1554039068 @default.
• W2129553429 cites W1964980904 @default.
• W2129553429 cites W1972055370 @default.
• W2129553429 cites W1972072719 @default.
• W2129553429 cites W1973136410 @default.
• W2129553429 cites W1975499390 @default.
• W2129553429 cites W1976431988 @default.
• W2129553429 cites W1988009678 @default.
• W2129553429 cites W2027379754 @default.
• W2129553429 cites W2032749734 @default.
• W2129553429 cites W2034172793 @default.
• W2129553429 cites W2046421292 @default.
• W2129553429 cites W2053592186 @default.
• W2129553429 cites W2063041378 @default.
• W2129553429 cites W2065412622 @default.
• W2129553429 cites W2072565544 @default.
• W2129553429 cites W2081162516 @default.
• W2129553429 cites W2082995557 @default.
• W2129553429 cites W2087759558 @default.
• W2129553429 cites W2091346098 @default.
• W2129553429 cites W2103833544 @default.
• W2129553429 cites W2105856585 @default.
• W2129553429 cites W2115446921 @default.
• W2129553429 cites W2117067428 @default.
• W2129553429 cites W2118901354 @default.
• W2129553429 cites W2126070472 @default.
• W2129553429 cites W2144849433 @default.
• W2129553429 cites W2166360182 @default.
• W2129553429 cites W2169125995 @default.
• W2129553429 cites W2171636541 @default.
• W2129553429 cites W2171926701 @default.
• W2129553429 cites W2180432502 @default.
• W2129553429 cites W97090241 @default.
• W2129553429 doi "https://doi.org/10.1002/hep.26005" @default.
• W2129553429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3524382" @default.
• W2129553429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22899584" @default.
• W2129553429 hasPublicationYear "2013" @default.
• W2129553429 type Work @default.
• W2129553429 sameAs 2129553429 @default.
• W2129553429 citedByCount "28" @default.
• W2129553429 countsByYear W21295534292014 @default.
• W2129553429 countsByYear W21295534292015 @default.
• W2129553429 countsByYear W21295534292016 @default.
• W2129553429 countsByYear W21295534292017 @default.
• W2129553429 countsByYear W21295534292018 @default.
• W2129553429 countsByYear W21295534292019 @default.
• W2129553429 countsByYear W21295534292020 @default.
• W2129553429 countsByYear W21295534292021 @default.
• W2129553429 countsByYear W21295534292022 @default.
• W2129553429 countsByYear W21295534292023 @default.
• W2129553429 crossrefType "journal-article" @default.
• W2129553429 hasAuthorship W2129553429A5010035779 @default.
• W2129553429 hasAuthorship W2129553429A5053160478 @default.
• W2129553429 hasAuthorship W2129553429A5073819824 @default.
• W2129553429 hasAuthorship W2129553429A5077612245 @default.
• W2129553429 hasAuthorship W2129553429A5090461114 @default.
• W2129553429 hasAuthorship W2129553429A5091016060 @default.
• W2129553429 hasBestOaLocation W21295534291 @default.
• W2129553429 hasConcept C123012128 @default.
• W2129553429 hasConcept C126322002 @default.
• W2129553429 hasConcept C144980905 @default.
• W2129553429 hasConcept C170493617 @default.
• W2129553429 hasConcept C176891718 @default.
• W2129553429 hasConcept C202751555 @default.
• W2129553429 hasConcept C203014093 @default.
• W2129553429 hasConcept C2779609443 @default.
• W2129553429 hasConcept C2781109936 @default.
• W2129553429 hasConcept C2781128415 @default.
• W2129553429 hasConcept C2911091166 @default.
• W2129553429 hasConcept C55493867 @default.
• W2129553429 hasConcept C71924100 @default.
• W2129553429 hasConcept C86803240 @default.
• W2129553429 hasConcept C98274493 @default.
• W2129553429 hasConceptScore W2129553429C123012128 @default.
• W2129553429 hasConceptScore W2129553429C126322002 @default.
• W2129553429 hasConceptScore W2129553429C144980905 @default.
• W2129553429 hasConceptScore W2129553429C170493617 @default.
• W2129553429 hasConceptScore W2129553429C176891718 @default.
• W2129553429 hasConceptScore W2129553429C202751555 @default.
• W2129553429 hasConceptScore W2129553429C203014093 @default.
• W2129553429 hasConceptScore W2129553429C2779609443 @default.
• W2129553429 hasConceptScore W2129553429C2781109936 @default.
• W2129553429 hasConceptScore W2129553429C2781128415 @default.
• W2129553429 hasConceptScore W2129553429C2911091166 @default.
• W2129553429 hasConceptScore W2129553429C55493867 @default.
• W2129553429 hasConceptScore W2129553429C71924100 @default.
• W2129553429 hasConceptScore W2129553429C86803240 @default.

• next