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- W2129574927 abstract "beta-Adrenergic receptor antagonists (beta-blockers) have a well-recognised antihypertensive action that is mediated through a reduction in cardiac output and in the release of renin from the kidneys and inhibition of the action of endogenous catecholamines on beta-adrenergic receptors. This class of drugs has been shown to reduce the incidence of cardiovascular disease. Recent evidence suggests that beta-blockers may also have an effect on bone structure, metabolism and fracture healing.This paper reviews in vitro and in vivo data that suggest beta-blockers have primarily an anabolic effect on bone metabolism.The sympathetic nervous system has a catabolic effect on bone, and in vitro studies have shown that adrenergic agonists stimulate bone resorption. The beta-blocker propranolol has been shown to increase bone formation in ovariectomised female rats. Also, recent observational clinical studies provide evidence to show that beta-blockers are associated with reduction in fracture risk in both men and women.Although there are some controversial studies, most research concludes that beta-blockers show promise in the treatment of osteoporosis and fracture healing." @default.
- W2129574927 created "2016-06-24" @default.
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- W2129574927 creator A5084655978 @default.
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- W2129574927 date "2008-08-12" @default.
- W2129574927 modified "2023-10-13" @default.
- W2129574927 title "The effect of β-blockers on bone metabolism as potential drugs under investigation for osteoporosis and fracture healing" @default.
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- W2129574927 doi "https://doi.org/10.1517/13543784.17.9.1281" @default.
- W2129574927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18694363" @default.
- W2129574927 hasPublicationYear "2008" @default.
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